Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shahar Zirkin"'
Autor:
Noa Gilat, Tzlil Tabachnik, Amit Shwartz, Tamar Shahal, Dmitry Torchinsky, Yael Michaeli, Gil Nifker, Shahar Zirkin, Yuval Ebenstein
Publikováno v:
Clinical Epigenetics, Vol 9, Iss 1, Pp 1-8 (2017)
Abstract Background The DNA modification 5-hydroxymethylcytosine (5hmC) is now referred to as the sixth base of DNA with evidence of tissue-specific patterns and correlation with gene regulation and expression. This epigenetic mark was recently repor
Externí odkaz:
https://doaj.org/article/5203e37d8759494f9b547de857ab40f9
Autor:
Daphna Levy, Ateret Davidovich, Shahar Zirkin, Yulia Frug, Amos M Cohen, Sara Shalom, Jeremy Don
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34736 (2012)
Potent survival effects have been ascribed to the serine/threonine kinase proto-oncogene PIM-2. Elevated levels of PIM-2 are associated with various malignancies. In human cells, a single Pim-2 transcript gives rise mainly to two protein isoforms (34
Externí odkaz:
https://doaj.org/article/614b875e681d4bd493d3c118a77ad8d8
Autor:
Sigal Avraham, Leonie Schütz, Larissa Käver, Andreas Dankers, Sapir Margalit, Yael Michaeli, Shahar Zirkin, Dmitry Torchinsky, Noa Gilat, Omer Bahr, Gil Nifker, Maya Koren-Michowitz, Elmar Weinhold, Yuval Ebenstein
5-methylcytosine and 5-hydroxymethylcytosine are epigenetic modifications involved in gene regulation and cancer. Here, we describe a new, simple, and high-throughput platform for multi-colour epigenetic analysis. The novelty of our approach is the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::547eed855b166af039cba4709dc271c7
https://doi.org/10.1101/2022.10.31.513813
https://doi.org/10.1101/2022.10.31.513813
Autor:
Noa Gilat, Michal Caspi, Sapir Margalit, Dinorah Friedmann-Morvinski, Shelly Loewenstein, Revital Kariv, Shahar Zirkin, Tamar Shahal, Prerna Magod, Guy Lahat, Yuval Ebenstein, Sigal Avraham, Yael Michaeli, Rina Rosin-Arbesfeld
Publikováno v:
International Journal of Cancer. 146:115-122
Epigenetic transformations may provide early indicators for cancer and other disease. Specifically, the amount of genomic 5-hydroxymethylcytosine (5-hmC) was shown to be globally reduced in a wide range of cancers. The integration of this global biom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1b379759a6772e5c41ef041a877085
https://doi.org/10.1002/ijc.32519
https://doi.org/10.1002/ijc.32519
Autor:
Hila Sharim, Shahar Zirkin, Sigal Avraham, Carmit Levy, Dmitry Torchinsky, Sapir Margalit, Yuval Ebenstein, Nadav Elkoshi, Yael Michaeli, Noa Gilat
Publikováno v:
Analytical Chemistry
Knowing the amount and type of DNA damage is of great significance for a broad range of clinical and research applications. However, existing methods are either lacking in their ability to distinguish between types of DNA damage or limited in their s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed098d685ed4ce97ed7a54d4d6ed1630
https://pubmed.ncbi.nlm.nih.gov/32578422
https://pubmed.ncbi.nlm.nih.gov/32578422
Autor:
Noa Gilat, Jonathan Jeffet, Shuyi Wu, Shahar Zirkin, Hila Sharim, Assaf Grunwald, Luping Xu, Yuval Ebenstein, Dmitry Torchinsky, Quanshui Zheng
Publikováno v:
Nanotechnology
DNA combing is a widely used method for stretching and immobilising DNA molecules on a surface. Fluorescent labelling of genomic information enables high-resolution optical analysis of DNA at the single-molecule level. Despite its simplicity, the app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b6ffdabdbca27c5eaa5ebbdfeb3f93
Publikováno v:
Journal of Biological Chemistry. 288:21770-21783
The oncogenic nature ascribed to the PIM-2 kinase relies mostly on phosphorylation of substrates that act as pro-survival/anti-apoptotic factors. Nevertheless, pro-survival effects can also result from activating DNA repair mechanisms following damag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565b471e12460b34f7c667b980c6d78e
https://doi.org/10.1074/jbc.m113.458851
https://doi.org/10.1074/jbc.m113.458851
Autor:
Sara Shalom, Jeremy Don, Daphna Levy, Amos Cohen, Yulia Frug, Shahar Zirkin, Ateret Davidovich
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34736 (2012)
PLoS ONE
PLoS ONE
Potent survival effects have been ascribed to the serine/threonine kinase proto-oncogene PIM-2. Elevated levels of PIM-2 are associated with various malignancies. In human cells, a single Pim-2 transcript gives rise mainly to two protein isoforms (34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dee10b61294fd022b53b241b9765558
https://doi.org/10.1371/journal.pone.0034736
https://doi.org/10.1371/journal.pone.0034736
Autor:
Shuyi Wu, Jonathan Jeffet, Assaf Grunwald, Hila Sharim, Noa Gilat, Dmitry Torchinsky, Quanshui Zheng, Shahar Zirkin, Luping Xu, Yuval Ebenstein
Publikováno v:
Nanotechnology; 1/25/2019, Vol. 30 Issue 4, p1-1, 1p
Autor:
Yael Michaeli, Amit Shwartz, Tzlil Tabachnik, Gil Nifker, Dmitry Torchinsky, Yuval Ebenstein, Shahar Zirkin, Tamar Shahal, Noa Gilat
Publikováno v:
Clinical Epigenetics, Vol 9, Iss 1, Pp 1-8 (2017)
Clinical Epigenetics
Clinical Epigenetics
Background The DNA modification 5-hydroxymethylcytosine (5hmC) is now referred to as the sixth base of DNA with evidence of tissue-specific patterns and correlation with gene regulation and expression. This epigenetic mark was recently reported as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af17d32c16b6ab17b5fe6ba8ea32c60