Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Shahar Sukenik"'
Autor:
Siyuan Hao, Ye Jin Lee, Nadav Benhamou Goldfajn, Eduardo Flores, Jindayi Liang, Hannah Fuehrer, Justin Demmerle, Jennifer Lippincott-Schwartz, Zhe Liu, Shahar Sukenik, Danfeng Cai
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109927- (2024)
Summary: YAP/TEAD signaling is essential for organismal development, cell proliferation, and cancer progression. As a transcriptional coactivator, how YAP activates its downstream target genes is incompletely understood. YAP forms biomolecular conden
Externí odkaz:
https://doaj.org/article/93e023ecedcf4265b02598fc8193056d
Autor:
Cesar L. Cuevas-Velazquez, Tamara Vellosillo, Karina Guadalupe, Hermann Broder Schmidt, Feng Yu, David Moses, Jennifer A. N. Brophy, Dante Cosio-Acosta, Alakananda Das, Lingxin Wang, Alexander M. Jones, Alejandra A. Covarrubias, Shahar Sukenik, José R. Dinneny
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Methods to monitor osmolarity-dependent changes in cell are currently lacking. Here the authors use the Arabidopsis intrinsically disordered AtLEA4-5 protein, which is expressed in plants under water deficit, to develop a FRET biosensor (SED1) to mon
Externí odkaz:
https://doaj.org/article/6c5fabb7d3ce4541b5c43c9f778914b1
Autor:
Ronen Gabizon, Tobias Brandt, Shahar Sukenik, Noa Lahav, Mario Lebendiker, Deborah E Shalev, Dmitry Veprintsev, Assaf Friedler
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38060 (2012)
Oligomerization plays a major role in regulating the activity of many proteins, and in modulating their interactions. p53 is a homotetrameric transcription factor that has a pivotal role in tumor suppression. Its tetramerization domain is contained w
Externí odkaz:
https://doaj.org/article/d339838ef4e447cfb6e596b794d489e5
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15608 (2011)
Amyloid fiber formation is a specific form of protein aggregation, often resulting from the misfolding of native proteins. Aimed at modeling the crowded environment of the cell, recent experiments showed a reduction in fibrillation halftimes for amyl
Externí odkaz:
https://doaj.org/article/4f9c13fda75d43e19e63758bf37c779f
Autor:
Tali H Reingewertz, Deborah E Shalev, Shahar Sukenik, Ofrah Blatt, Shahar Rotem-Bamberger, Mario Lebendiker, Sarit Larisch, Assaf Friedler
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24655 (2011)
ARTS (Sept4_i2) is a mitochondrial pro-apoptotic protein that functions as a tumor suppressor. Its expression is significantly reduced in leukemia and lymphoma patients. ARTS binds and inhibits XIAP (X-linked Inhibitor of Apoptosis protein) by intera
Externí odkaz:
https://doaj.org/article/6bbcdbfa1a714e399f748a3a73902b01
Autor:
Feng Yu, Shahar Sukenik
Publikováno v:
The Journal of Physical Chemistry B. 127:4235-4244
Intrinsically disordered protein regions (IDRs) make up over 30% of the human proteome and instead of a native, well-folded structure exist in a dynamic conformational ensemble. Tethering IDRs to a surface (for example, the surface of a well-folded r
Publikováno v:
Biophysical Journal. 122:1414-1422
Publikováno v:
Chemical Reviews.
Publikováno v:
Journal of computational physics. 444
We present a new approach to compute and analyze the dynamical electro-geometric properties of proteins undergoing conformational changes. The molecular trajectory is obtained from Markov state models, and the electrostatic potential is calculated us
Publikováno v:
Biophysical Journal. 122:346a-347a