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Akademický článek

Cell-autonomous role of leucine-rich repeat kinase in the protection of dopaminergic neuron survival

Autor: Jongkyun Kang, Guodong Huang, Long Ma, Youren Tong, Anu Shahapal, Phoenix Chen, Jie Shen

Publikováno v: eLife, Vol 12 (2024)

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson’s disease (PD). However, whether LRRK2 mutations cause PD and degeneration of dopaminergic (DA) neurons via a toxic gain-of-function or a loss-of-funct

Externí odkaz: https://doaj.org/article/fabed0c9954044a7be4f1170eeaaa540

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Akademický článek

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Akademický článek

FAM19A5 Deficiency Mitigates the Aβ Plaque Burden and Improves Cognition in Mouse Models of Alzheimer's Disease.

Autor: Park S; Department of Biomedical Sciences, Graduate School of Medicine, Korea University, Seoul 02841, Korea., Shahapal A; Department of Biomedical Sciences, Graduate School of Medicine, Korea University, Seoul 02841, Korea., Yoo S; Neuracle Science Co., Ltd., Seoul 02841, Korea., Kwak H; Neuracle Science Co., Ltd., Seoul 02841, Korea., Lee M; Neuracle Science Co., Ltd., Seoul 02841, Korea., Lee SM; Neuracle Science Co., Ltd., Seoul 02841, Korea., Hwang JI; Department of Biomedical Sciences, Graduate School of Medicine, Korea University, Seoul 02841, Korea., Seong JY; Department of Biomedical Sciences, Graduate School of Medicine, Korea University, Seoul 02841, Korea.; Neuracle Science Co., Ltd., Seoul 02841, Korea.

Publikováno v: Experimental neurobiology [Exp Neurobiol] 2024 Aug 31; Vol. 33 (4), pp. 193-201.

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Akademický článek

FAM19A5 Expression During Embryogenesis and in the Adult Traumatic Brain of FAM19A5-LacZ Knock-in Mice

Autor: Anu Shahapal, Eun Bee Cho, Hyo Jeong Yong, Inyoung Jeong, Hoyun Kwak, Jae Keun Lee, Wonkyum Kim, Bongcheol Kim, Hae-Chul Park, Won Suk Lee, Hyun Kim, Jong-Ik Hwang, Jae Young Seong

Publikováno v: Frontiers in Neuroscience, Vol 13 (2019)

FAM19A5 is a secretory protein that is predominantly expressed in the brain. Although the FAM19A5 gene has been found to be associated with neurological and/or psychiatric diseases, only limited information is available on its function in the brain.

Externí odkaz: https://doaj.org/article/a5437c09bc414f328b5ff28e19c62391

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Motor Impairments and Dopaminergic Defects Caused by Loss of Leucine-Rich Repeat Kinase Function in Mice

Autor: Guodong Huang, Daniel W. Bloodgood, Jongkyun Kang, Anu Shahapal, Phoenix Chen, Konstantin Kaganovsky, Jae-Ick Kim, Jun B. Ding, Jie Shen

Publikováno v: J Neurosci

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease (PD), but the pathogenic mechanism underlying LRRK2 mutations remains unresolved. In this study, we investigate the consequence of inactivation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf418267b5b278fbaad753e6e8065b1
https://doi.org/10.1523/jneurosci.0140-22.2022

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Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survival.

Autor: Kang J; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States of America., Huang G; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States of America., Ma L; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States of America., Tong Y; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States of America., Shahapal A; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States of America., Chen P; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States of America., Shen J; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States of America.; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, United States of America.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 07. Date of Electronic Publication: 2024 Mar 07.

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