Comprehensive mapping of cystic fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site.

Autor: Molinski SV; Cyclica Inc., Toronto, Ontario, M5C 1C4, Canada., Shahani VM; Cyclica Inc., Toronto, Ontario, M5C 1C4, Canada., Subramanian AS; Cyclica Inc., Toronto, Ontario, M5C 1C4, Canada., MacKinnon SS; Cyclica Inc., Toronto, Ontario, M5C 1C4, Canada., Woollard G; Cyclica Inc., Toronto, Ontario, M5C 1C4, Canada., Laforet M; Cyclica Inc., Toronto, Ontario, M5C 1C4, Canada., Laselva O; Programme in Molecular Structure and Function, Research Institute, Hospital for Sick Children, Toronto, Ontario, M5G 0A4, Canada., Morayniss LD; Cyclica Inc., Toronto, Ontario, M5C 1C4, Canada., Bear CE; Programme in Molecular Structure and Function, Research Institute, Hospital for Sick Children, Toronto, Ontario, M5G 0A4, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada., Windemuth A; Cyclica Inc., Toronto, Ontario, M5C 1C4, Canada.

Publikováno v: Proteins [Proteins] 2018 Aug; Vol. 86 (8), pp. 833-843. Date of Electronic Publication: 2018 Apr 10.

Computational proteome-wide screening predicts neurotoxic drug-protein interactome for the investigational analgesic BIA 10-2474.

Autor: Molinski SV; Cyclica Inc., Toronto, Ontario, Canada., Shahani VM; Cyclica Inc., Toronto, Ontario, Canada., MacKinnon SS; Cyclica Inc., Toronto, Ontario, Canada., Morayniss LD; Cyclica Inc., Toronto, Ontario, Canada., Laforet M; Cyclica Inc., Toronto, Ontario, Canada., Woollard G; Cyclica Inc., Toronto, Ontario, Canada., Kurji N; Cyclica Inc., Toronto, Ontario, Canada., Sanchez CG; Division of Pulmonary Diseases, Critical Care and Environmental Medicine, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA., Wodak SJ; Cyclica Inc., Toronto, Ontario, Canada., Windemuth A; Cyclica Inc., Toronto, Ontario, Canada. Electronic address: andreas.windemuth@cyclicarx.com.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2017 Jan 29; Vol. 483 (1), pp. 502-508. Date of Electronic Publication: 2016 Dec 20.

Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma.

Autor: Haftchenary S; Department of Chemical and Physical Sciences, University of Toronto at Mississauga , Mississauga, ON L5L 1C6, Canada., Luchman HA; Hotchkiss Brain Institute and Department of Cell Biology and Anatomy, University of Calgary , Calgary, AB T2N 1N4, Canada., Jouk AO; Department of Chemical and Physical Sciences, University of Toronto at Mississauga , Mississauga, ON L5L 1C6, Canada., Veloso AJ; Department of Chemistry, University of Toronto at Scarborough , Toronto, ON M1C 1A4, Canada., Page BD; Department of Chemical and Physical Sciences, University of Toronto at Mississauga , Mississauga, ON L5L 1C6, Canada., Cheng XR; Department of Chemistry, University of Toronto at Scarborough , Toronto, ON M1C 1A4, Canada., Dawson SS; Department of Chemical and Physical Sciences, University of Toronto at Mississauga , Mississauga, ON L5L 1C6, Canada., Grinshtein N; Cell Biology Program and James Burrel Laboratories at the Hospital for Sick Children , Toronto, ON M5G 1X8, Canada., Shahani VM; Department of Chemical and Physical Sciences, University of Toronto at Mississauga , Mississauga, ON L5L 1C6, Canada., Kerman K; Department of Chemistry, University of Toronto at Scarborough , Toronto, ON M1C 1A4, Canada., Kaplan DR; Cell Biology Program and James Burrel Laboratories at the Hospital for Sick Children , Toronto, ON M5G 1X8, Canada., Griffin C; Drug Discovery Program, Ontario Institute for Cancer Research , Toronto, ON M5G 0A3, Canada., Aman AM; Drug Discovery Program, Ontario Institute for Cancer Research , Toronto, ON M5G 0A3, Canada., Al-Awar R; Drug Discovery Program, Ontario Institute for Cancer Research , Toronto, ON M5G 0A3, Canada., Weiss S; Hotchkiss Brain Institute and Department of Cell Biology and Anatomy, University of Calgary , Calgary, AB T2N 1N4, Canada., Gunning PT; Department of Chemical and Physical Sciences, University of Toronto at Mississauga , Mississauga, ON L5L 1C6, Canada.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2013 Sep 08; Vol. 4 (11), pp. 1102-7. Date of Electronic Publication: 2013 Sep 08 (Print Publication: 2013).

Identification of NAE Inhibitors Exhibiting Potent Activity in Leukemia Cells: Exploring the Structural Determinants of NAE Specificity.

Autor: Lukkarila JL; Department of Chemistry, University of Toronto Mississauga , 3359 Mississauga Road North, Mississauga, ON, L5L1C6, Canada., da Silva SR; Department of Chemistry, University of Toronto Mississauga , 3359 Mississauga Road North, Mississauga, ON, L5L1C6, Canada., Ali M; Division of Hematology and Oncology, The Princess Margaret Hospital and the Ontario Cancer Institute , 610 University Avenue, Toronto, ON, M5G2M9, Canada., Shahani VM; Department of Chemistry, University of Toronto Mississauga , 3359 Mississauga Road North, Mississauga, ON, L5L1C6, Canada., Xu GW; Division of Hematology and Oncology, The Princess Margaret Hospital and the Ontario Cancer Institute , 610 University Avenue, Toronto, ON, M5G2M9, Canada., Berman J; Dalton Medicinal Chemistry Inc. , 349 Wildcat Road, Toronto, ON, M3J 2S3, Canada., Roughton A; Dalton Medicinal Chemistry Inc. , 349 Wildcat Road, Toronto, ON, M3J 2S3, Canada., Dhe-Paganon S; Structural Genomics Consortium, University of Toronto , 100 College Street, Toronto, ON, M5G1L5, Canada., Schimmer AD; Division of Hematology and Oncology, The Princess Margaret Hospital and the Ontario Cancer Institute , 610 University Avenue, Toronto, ON, M5G2M9, Canada., Gunning PT; Department of Chemistry, University of Toronto Mississauga , 3359 Mississauga Road North, Mississauga, ON, L5L1C6, Canada.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2011 May 16; Vol. 2 (8), pp. 577-82. Date of Electronic Publication: 2011 May 16 (Print Publication: 2011).

Identification of Purine-Scaffold Small-Molecule Inhibitors of Stat3 Activation by QSAR Studies.

Autor: Shahani VM, Yue P, Haftchenary S, Zhao W, Lukkarila JL, Zhang X, Ball D, Nona C, Gunning PT, Turkson J

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2011 Jan 13; Vol. 2 (1), pp. 79-84. Date of Electronic Publication: 2010 Oct 25.