Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Shahana Sengupta"'
Autor:
Mahesh M Umapathysivam, Elisa Araldi, Benoit Hastoy, Adem Y Dawed, Hasan Vatandaslar, Shahana Sengupta, Adrian Kaufmann, Søren Thomsen, Bolette Hartmann, Anna E Jonsson, Hasan Kabakci, Swaraj Thaman, Niels Grarup, Christian T Have, Kristine Færch, Anette P Gjesing, Sameena Nawaz, Jane Cheeseman, Matthew J Neville, Oluf Pedersen, Mark Walker, Christopher Jennison, Andrew T Hattersley, Torben Hansen, Fredrik Karpe, Jens J Holst, Angus G Jones, Michael Ristow, Mark I McCarthy, Ewan R Pearson, Markus Stoffel, Anna L Gloyn
Patients with type 2 diabetes vary in their response to currently available therapeutic agents (including GLP-1 receptor agonists) leading to suboptimal glycemic control and increased risk of complications. We show that human carriers of hypomorphic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::157451176660a0e343840228d18dc298
https://doi.org/10.1101/2023.04.07.23288197
https://doi.org/10.1101/2023.04.07.23288197
Autor:
Franco Moritz, Melina Claussnitzer, Roger D. Cox, Kirill S. Smirnov, Julius Honecker, Philippe Schmitt-Kopplin, Sophie Strobel, Wendy A. Bickmore, Julia Petzold, Tom Nicol, Michelle Simon, Samantha Laber, Lydia Teboul, Sara Forcisi, Hans Hauner, Harald Grallert, Shahana Sengupta, Loubna Al Sadat, Liz Bentley, Iain Williamson, Margit Heier, Joffrey Mianné, Helen S Long, Thomas Agnew, Cecilia M. Lindgren, Rebecca Dumbell
Publikováno v:
Science Advances
The obesity-linked FTO regulatory circuitry shows cross-species molecular, cellular, metabolic, and organismal conservation.
Variants in FTO have the strongest association with obesity; however, it is still unclear how those noncoding variants m
Variants in FTO have the strongest association with obesity; however, it is still unclear how those noncoding variants m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a22ffadc36c6491bd827637674e7497
http://europepmc.org/articles/PMC8294759
http://europepmc.org/articles/PMC8294759
Autor:
Mahesh M. Umapathysivam, Anne Raimondo, Shahana Sengupta, Markku Laakso, Peter S. Chines, Anna L. Gloyn, Anne Clark, Hanna Huopio, Antje Grotz, Lori L. Bonnycastle, Amy J. Swift, Benoit Hastoy, Francis S. Collins
Publikováno v:
Diabetes. 68
Peptidylglycine α-amidating monooxygenase (PAM) catalyses the amidation of glycine-extended peptides, thereby maximising their biological potency. We recently showed that coding alleles in PAM mediate type 2 diabetes (T2D) risk through alterations t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::348bd26b300d68758e2c7269968c5205
https://doi.org/10.2337/db19-25-or
https://doi.org/10.2337/db19-25-or
Autor:
Soren K. Thomsen, Nicola L. Beer, Mark I. McCarthy, Mahesh M. Umapathysivam, Jenny C Censin, Anna L. Gloyn, Christopher J. Groves, Xiao Qing Dai, Austin Bautista, Benoit Hastoy, Anthony Payne, Shahana Sengupta, Jocelyn E. Manning Fox, Patrick E. MacDonald, Anubha Mahajan, Anne Raimondo, P Rorsman, Anne Clark, Amy Barrett, Aliya F. Spigelman
Publikováno v:
Nature Genetics
The molecular mechanisms underpinning susceptibility loci for type 2 diabetes (T2D) remain poorly understood. Coding variants in peptidylglycine α-amidating monooxygenase (PAM) are associated with both T2D risk and insulinogenic index. Here, we demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b615f2323fe2cadbea8c8cc5ba3c7977