Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Shahana S. Mahajan"'
Autor:
Marian Raghubir, Syeda M. Azeem, Rifat Hasnat, Chowdhury N. Rahman, Linda Wong, Salina Yan, Yu Qi Huang, Raquel Zhagui, Angelina Blyufer, Iffat Tariq, Cassey Tam, Sonam Lhamo, Lucas Cecilio, Yesmin Chowdhury, Shraddha ChandThakuri, Shahana S. Mahajan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Our lab has previously demonstrated Riluzole to be an effective drug in inhibiting proliferation and inducing apoptosis in both human and mouse osteosarcoma. Yes-associated protein is a transcription co-activator, known to be involved in cel
Externí odkaz:
https://doaj.org/article/2b0a957988c74071ab9be72bced3b431
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7944 (2022)
Although osteosarcoma is the most common primary malignant bone tumor, chemotherapeutic drugs and treatment have failed to increase the five-year survival rate over the last three decades. We previously demonstrated that type 5 metabotropic glutamate
Externí odkaz:
https://doaj.org/article/7624748c96e54a53a991d4e78a9a3a6d
Autor:
Sally Liao, Yuleisy Ruiz, Hira Gulzar, Zarina Yelskaya, Lyes Ait Taouit, Murielle Houssou, Trisha Jaikaran, Yuriy Schvarts, Kristina Kozlitina, Upal Basu-Roy, Alka Mansukhani, Shahana S Mahajan
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171256 (2017)
Osteosarcomas are malignant tumors of bone, most commonly seen in children and adolescents. Despite advances in modern medicine, the poor survival rate of metastatic osteosarcoma has not improved in two decades. In the present study we have investiga
Externí odkaz:
https://doaj.org/article/b02f4bdb126d4de1a798365a694b3b82
Autor:
Iffat Tariq, Shahana S. Mahajan, Thongthai Thavornwatanayong, Cassey Tam, Sonam Lhamo, Angelina Blyufer
Publikováno v:
International Journal of Oncology
Riluzole, a glutamate release inhibitor, has been in use for the treatment of amyotrophic lateral sclerosis for over two decades since its approval by the Food and Drug Administration. Recently, riluzole has been evaluated in cancer cells and indicat
Autor:
Syeda M Azeem, Rifat Hasnat, Linda Wong, Salina Yan, Yesmin Chowdhury, Shraddha ChandThakuri, Iffat Tariq, Shahana S. Mahajan, Yu Qi Huang, Angelina Blyufer, Sonam Lhamo, Raquel Zhagui, Lucas Cecilio, Cassey Tam, Marian Raghubir, Chowdhury Nowshin Rahman
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Our lab has previously demonstrated Riluzole to be an effective drug in inhibiting proliferation and inducing apoptosis in both human and mouse osteosarcoma. Yes-associated protein is a transcription co-activator, known to be involved in cell prolife
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64588 (2013)
Glioblastomas exploit various molecular pathways to promote glutamate- dependent growth by activating the AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid) receptor, the group II metabotropic glutamate receptor, mGluR, and the epider
Externí odkaz:
https://doaj.org/article/d0b8869e50cc48d587ba619d09a7dc48
Publikováno v:
Oncology Reports
Osteosarcomas are the most commonly occurring malignant bone cancer in young individuals. The survival rate of patients with metastatic osteosarcoma is low and has been stagnant for over two decades. We previously demonstrated that the glutamate rele
Autor:
Yuleisy Ruiz, David Lyden, Kristina I. Fabijanic, Shahana S. Mahajan, Trisha Jaikaran, Ayuko Hoshino, Hiroshi Matsui, Justin Fang, Ayako Hashimoto, Stefan Silver, Shengping Zheng, Sham Rampersaud, Murielle Houssou, Zhiwei Yin, Zengyan Wei
Publikováno v:
Nano Letters. 16:7357-7363
Although a range of nanoparticles have been developed as drug delivery systems in cancer therapeutics, this approach faces several important challenges concerning nanocarrier circulation, clearance, and penetration. The impact of reducing nanoparticl
Autor:
Kenneth D. Carr, Carlo B. Guarini, Megna Khatri, Soledad Cabeza de Vaca, Duo Xu, Charlotte M. Wincott, Jainne M. Ferreira, Jing Wang, Julian K. Horwitz, Robert C. Froemke, Yossef Goffer, Edward B. Ziff, Roseann F. Titcombe, Ipe Ninan, Salvatore Incontro, Dave S. Marzan, Latika Khatri, Chiye Aoki, Shahana S. Mahajan, Shannon O. Antoine, James A. D’amour, David S. Tukey, Diana T. Hartner
Publikováno v:
The Journal of Neuroscience. 33:6123-6132
The mechanisms by which natural rewards such as sugar affect synaptic transmission and behavior are largely unexplored. Here, we investigate regulation of nucleus accumbens synapses by sucrose intake. Previous studies have shown that AMPA receptor (A
Publikováno v:
Neuroscience. 189:305-315
AMPA receptors are glutamate receptors that are tetramers of various combinations of GluR1-4 subunits. AMPA receptors containing GluR1, 3 and 4 are Ca2+ permeable, however, AMPA receptors containing even a single subunit of GluR2 are Ca2+ impermeable