Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Shahadat Ahmed"'
Autor:
Joseph Alex Davis, Biju Benjamin, Shahadat Ahmed, Voleti Sreedhara Rao, Vamshi Krishna Tulasi, Kona S Srinivas, Jitendra A. Sattigeri, Anil Gorakshnath Gadhave, Dhrubajyoti Datta, Balasaheb Gangadhar Jadhav, Abhijit Ray, Ian Anthony Cliffe, Pradip Kumar Bhatnagar, Tarun Jain, Sunitha Udupa, Garima Jain, Satya M. Chilla, Yogender Singh, Sachin Sethi, Geeta Vani Rayasam, Vinay S. Bansal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2313-2318
Designing drug candidates exhibiting polypharmacology is one of the strategies adopted by medicinal chemists to address multifactorial diseases. Metabolic disease is one such multifactorial disorder characterized by hyperglycaemia, hypertension and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d230bbbcb31eefbb1696499371c1800
https://doi.org/10.1016/j.bmcl.2017.04.036
https://doi.org/10.1016/j.bmcl.2017.04.036
Autor:
Shahadat Ahmed, Kishore Narayanan, Chetan Pandit, Mukherjee, Subhendu, Amol V. Gadakh, Sivapriya Marappan, Samiulla Syed Dodheri, Surendranath, Sanjeev Barahagar, Sushmita, Ratna, O, Krishna Mohan, Avula Rajasekhar, Sammeta Srinivasa Raju, Vasantha Kumar G, Dastagiri B, Ganipisetty, Srinivasa RAO, N Kasieswara, S, Vijaya Shekar, S Jagan Mohan Reddy, Chikkanna, Dinesh, Murali Ramachandra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::555da876449a0949253277abea1f6b50
Autor:
Sajad Mohammed, George Hynd, Nicholas C. Ray, Hazel Hunt, Shahadat Ahmed, Steve Daly, Peter Lockey, Gerry Buckley, Robert Roe, Jon Sutton, Robin D. Clark, Christine Blasey, Joe Belanoff, Elizabeth O'connor
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7376-7380
We report the optimization of a series of non-steroidal GR antagonists that led to the identification of compound 7. This compound is efficacious when dosed orally in an olanzapine-induced weight gain model in rats.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541110052c7b57a2ea48db89fe09a186
https://doi.org/10.1016/j.bmcl.2012.10.074
https://doi.org/10.1016/j.bmcl.2012.10.074
Autor:
Shuchita, Singh, Subhasis, Roy, Sachin, Sethi, Biju, Benjamin, Sindhuja, Sundaram, Vivek, Khanna, Sachin R, Kandalkar, Chanchal, Pal, Rajiv, Kant, Ashok Kumar, Patra, Geetavani, Rayasam, Shivani, Mittra, Kulvinder Singh, Saini, Jyoti, Paliwal, Anita, Chugh, Shahadat, Ahmed, Jitendra, Sattigeri, Ian, Cliff, Abhijit, Ray, Vinay S, Bansal, Pradip Kumar, Bhatnagar, Joseph Alex, Davis
Publikováno v:
European Journal of Pharmacology. 652:157-163
Dipeptidyl peptidase IV (DPP-IV) inhibiton is a well recognized approach to treat Type 2 diabetes. RBx-0597 is a novel DPP-IV inhibitor discovered in our laboratory. The aim of the present study was to characterize the pharmacological profiles of RBx
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d5b513e1fa7c795e5b823a6d3c1c76
https://doi.org/10.1016/j.ejphar.2010.06.001
https://doi.org/10.1016/j.ejphar.2010.06.001
Publikováno v:
The Journal of Organic Chemistry. 71:2922-2925
The syntheses of four pyrimidine C-nucleosides are described. These derivatives are designed as mimics of dC and dU, and in that respect, each can form two hydrogen bonds with complementary dG or dA residues. The minor groove O2 carbonyl in each deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d594a2017fcb8daf084cb4d79f03f9
https://doi.org/10.1021/jo060066y
https://doi.org/10.1021/jo060066y
Publikováno v:
Synthetic Communications. 31:3281-3287
A new and efficient method for synthesis of 1,4-oxazepine has been developed utilizing I2-NaHCO3 promoted intramolecular cyclisation of N-progargyl-β-hydroxylmethyl enamide. The method is mild and simple.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92f79efac64d97a69547458006aed253
https://doi.org/10.1081/scc-100106037
https://doi.org/10.1081/scc-100106037
Publikováno v:
Synthetic Communications. 30:771-777
Arylidenemalononitrile undergoes facile exchange of dicyano methylene group with β-formyl steroidal enamide as well as aromatic aldehydes under mild base catalysed reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::596a4b8c38b9e4f0920a0783d9a7dc16
https://doi.org/10.1080/00397910008087379
https://doi.org/10.1080/00397910008087379
Publikováno v:
The Journal of Organic Chemistry. 65:922-925
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16cc79b81b14cb6241da2d65236021d6
https://doi.org/10.1021/jo9912911
https://doi.org/10.1021/jo9912911
Autor:
Romesh C. Boruah, Shahadat Ahmed
Publikováno v:
ChemInform. 28
A facile synthesis of a pyrido fused steroidal D-ring and functionalised pyridine is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72f1430fadefe74011a8c21dd7ebe985
https://doi.org/10.1002/chin.199707057
https://doi.org/10.1002/chin.199707057