Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Shahab, Asgharzadeh"'
Comparison of human pluripotent stem cell differentiation protocols to generate neuroblastoma tumors
Autor:
Bo Cheng, Wanqi Fang, Steven Pastor, Alexander R. March, Tania Porras, Hong-Wei Wu, Miriam Velez, Chintan Parekh, John M. Maris, Shahab Asgharzadeh, Miller Huang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Neuroblastoma is the most common pediatric extracranial solid tumor and is derived from trunk neural crest cells (tNCC) and its progenitor sympathoadrenal (SA) cells. While human pluripotent stem cell (PSC) models of neuroblastoma have been
Externí odkaz:
https://doaj.org/article/8060f3e4246446d5ad9a05f143d8aa9b
Autor:
Danny Lascano, Michael J. Zobel, William G. Lee, Stephanie Y. Chen, Abigail Zamora, Grace E. Asuelime, So Yung Choi, Antonios Chronopoulos, Shahab Asgharzadeh, Araz Marachelian, Jinseok Park, Michael A. Sheard, Eugene S. Kim
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract C–C motif chemokine ligand 2 (CCL2) is a monocyte chemoattractant that promotes metastatic disease and portends a poor prognosis in many cancers. To determine the potential of anti-CCL2 inhibition as a therapy for recurrent metastatic dise
Externí odkaz:
https://doaj.org/article/179f9be33fdc468ab4b9283cf07129ea
Autor:
Miller Huang, Wanqi Fang, Alvin Farrel, Linwei Li, Antonios Chronopoulos, Nicole Nasholm, Bo Cheng, Tina Zheng, Hiroyuki Yoda, Megumi J. Barata, Tania Porras, Matthew L. Miller, Qiqi Zhen, Lisa Ghiglieri, Lauren McHenry, Linyu Wang, Shahab Asgharzadeh, JinSeok Park, W. Clay Gustafson, Katherine K. Matthay, John M. Maris, William A. Weiss
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113927- (2024)
Summary: Neuroblastoma is the most common extracranial solid tumor of childhood. While MYCN and mutant anaplastic lymphoma kinase (ALKF1174L) cooperate in tumorigenesis, how ALK contributes to tumor formation remains unclear. Here, we used a human st
Externí odkaz:
https://doaj.org/article/046ecfadd1a240a6bf1aaf35a0e740fe
Autor:
Rajen Mody, KyungMann Kim, Paul M Sondel, Amy K Erbe, Julie Park, Sabah Servaes, Jen Birstler, Wendy B London, Jung-Tung Hung, Alice L Yu, John M Maris, Mitch B Diccianni, Arlene Naranjo, Fan F Zhang, Arika S Feils, Barry L Shulkin, Varsha Mathew, Marguerite T Parisi, Shahab Asgharzadeh, Rochelle Bagatell
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)
Background In the Children’s Oncology Group ANBL1221 phase 2 trial for patients with first relapse/first declaration of refractory high-risk neuroblastoma, irinotecan and temozolomide (I/T) combined with either temsirolimus (TEMS) or immunotherapy
Externí odkaz:
https://doaj.org/article/443a5adb348f4ea680fa7f58633c74ff
Autor:
Kevin Louault, Tania Porras, Meng-Hua Lee, Sakunthala Muthugounder, Rebekah J. Kennedy, Laurence Blavier, Emily Sarte, G. Esteban Fernandez, Fusheng Yang, Bruce R. Pawel, Hiroyuki Shimada, Shahab Asgharzadeh, Yves A. DeClerck
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Tumor-associated macrophages (TAM) and cancer-associated fibroblasts (CAF) and their precursor mesenchymal stromal cells (MSC) are often detected together in tumors, but how they cooperate is not well understood. Here, we show that TAM and CAF are th
Externí odkaz:
https://doaj.org/article/e3a9711c53f144c9ad2f0492fa1ecbf7
Autor:
Babak Moghimi, Sakunthala Muthugounder, Samy Jambon, Rachelle Tibbetts, Long Hung, Hamid Bassiri, Michael D. Hogarty, David M. Barrett, Hiroyuki Shimada, Shahab Asgharzadeh
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Antibodies targeting a tumor antigen, GD2, show some efficacy for neuroblastoma but induce severe neuropathic pain and peripheral neuropathy. Here the authors design a gated chimeric antigen receptor (CAR), using GD2 as the gate and another tumor ant
Externí odkaz:
https://doaj.org/article/92c07d10ceed4a499ccaa1bcf1c46793
Autor:
Nolan Ung, Cameron Goldbeck, Cassandra Man, Julianne Hoeflich, Ren Sun, Arianna Barbetta, Naim Matasci, Jonathan Katz, Jerry S. H. Lee, Shefali Chopra, Shahab Asgharzadeh, Mika Warren, Linda Sher, Rohit Kohli, Omid Akbari, Yuri Genyk, Juliet Emamaullee
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Rejection continues to be an important cause of graft loss in solid organ transplantation, but deep exploration of intragraft alloimmunity has been limited by the scarcity of clinical biopsy specimens. Emerging single cell immunoprofiling technologie
Externí odkaz:
https://doaj.org/article/4e0d78655b6b479689062a7acc28f65d
Autor:
Navin Pinto, Arlene Naranjo, Xiangming Ding, Fan F. Zhang, Emily Hibbitts, Rebekah Kennedy, Rachelle Tibbetts, Shannon Wong-Michalak, David W. Craig, Zarko Manojlovic, Michael D. Hogarty, Susan Kreissman, Rochelle Bagatell, Meredith S. Irwin, Julie R. Park, Shahab Asgharzadeh
Publikováno v:
Clinical Cancer Research. 29:1546-1556
Purpose: Patients ≥18 months of age with International Neuroblastoma Staging System (INSS) stage 3 unfavorable histology (UH), MYCN-nonamplified (MYCN-NA) tumors have favorable survival rates compared with other high-risk neuroblastoma populations.
Autor:
Soheila Shirinbak, Randall Y. Chan, Shilpa Shahani, Sakunthala Muthugounder, Rebekah Kennedy, Long T. Hung, G. Esteban Fernandez, Michael D. Hadjidaniel, Babak Moghimi, Michael A. Sheard, Alan L. Epstein, Muller Fabbri, Hiroyuki Shimada, Shahab Asgharzadeh
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Immune checkpoint therapy has resulted in minimal clinical response in many pediatric cancers. We sought to understand the influence of immune checkpoint inhibition using anti-PD-1 and anti-CTLA-4 antibodies individually, in combination, and after ch
Externí odkaz:
https://doaj.org/article/0915f141d7a649279983360de71ca579
Autor:
Shahab Asgharzadeh, Julie R. Park, Meredith S. Irwin, Rochelle Bagatell, Susan Kreissman, Michael D. Hogarty, Zarko Manojlovic, David W. Craig, Shannon Wong-Michalak, Rachelle Tibbetts, Rebekah Kennedy, Emily Hibbitts, Fan F. Zhang, Xiangming Ding, Arlene Naranjo, Navin Pinto
Supplemental Figure S2 Outcome by Chromosome 9 Status. (A) EFS and (B) OS by Chromosome 9 status
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1f1049793c78c32b226724ec63720f
https://doi.org/10.1158/1078-0432.22632949
https://doi.org/10.1158/1078-0432.22632949