Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Shah Unmesh G"'
Autor:
Melissa Kirkland, M A Powles, Francisco Velazquez, Eric R. Ashley, Nengxue Wang, Shah Unmesh G, Feroze Ujjainwalla, Taro E. Akiyama, Eric J. Gilbert, Charles Lee Jayne, Michele Pachanski, Dan Zhou, Scott D. Edmondson, Jerry Di Salvo, Andreas Verras, Maria Madeira, Takao Suzuki, Srikanth Venkatraman, Quang Truong, Wu Yin, Gregory L. Adams, Shouwu Miao
Publikováno v:
ACS Medicinal Chemistry Letters. 8:96-101
GPR120 (FFAR4) is a fatty acid sensing G protein coupled receptor (GPCR) that has been identified as a target for possible treatment of type 2 diabetes. A selective activator of GPR120 containing a chromane scaffold has been designed, synthesized, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5c4bd187bc901f79299111d7c132c57
https://doi.org/10.1021/acsmedchemlett.6b00394
https://doi.org/10.1021/acsmedchemlett.6b00394
Autor:
Mariappan V. Chelliah, Ian W. Davies, Yan Xia, John A. Howe, Srikanth Venkatraman, Shah Unmesh G, Francisco Velazquez, Randy R. Miller, Samuel Chackalamannil, Santhosh Neelamkavil, Zhuyan Guo, Martin C. Clasby, Aileen Soriano
Publikováno v:
ACS Medicinal Chemistry Letters. 7:1173-1178
A new class of hepatitis C NS3/4A inhibitors was identified by introducing a novel spirocyclic proline–P2 surrogate onto the P2–P4 macrocyclic core of MK-5172 (grazoprevir). The potency profile of new analogues showed excellent pan-genotypic acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f17e337afff84cf9a865c88293e12d7
https://doi.org/10.1021/acsmedchemlett.6b00321
https://doi.org/10.1021/acsmedchemlett.6b00321
Autor:
Christopher Joseph Sinz, Sarah Souza, Aimie M. Ogawa, Dennis Leung, Eric R. Ashley, Brande Thomas-Fowlkes, Maria Madeira, Mary Ann Powles, Effie Tozzo, Hong D. Chu, Feroze Ujjainwalla, Melissa Kirkland, Matthew Lombardo, Clare London, Jerry Di Salvo, Keith Eagen, John S. Debenham, Jason M. Cox, Ping Lan, Alejandro Crespo, Adam B. Weinglass, Taro E. Akiyama, Nengxue Wang, Henry M. Vaccaro, Michele Pachanski, Shah Unmesh G, Zhongxiang Sun, Mariappan V. Chelliah, James R. Tata, Michael A. Plotkin, Candice Alleyne, Takao Suzuki, Srikanth Venkatraman
Publikováno v:
ACS medicinal chemistry letters. 8(1)
Type 2 diabetes mellitus (T2DM) is an ever increasing worldwide epidemic, and the identification of safe and effective insulin sensitizers, absent of weight gain, has been a long-standing goal of diabetes research. G-protein coupled receptor 120 (GPR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a251742e59339ae232f1fad2130722
https://pubmed.ncbi.nlm.nih.gov/28105274
https://pubmed.ncbi.nlm.nih.gov/28105274
Autor:
Charles Lee Jayne, Francisco Velazquez, Zhuyan Guo, Donald M. Sperbeck, Murali Rajagopalan, Duane Burnette, Karen Marcantonio, Shouwu Miao, Sathesh Bhat, Santhosh Neelamkavil, Linda Brockunier, Stacia Kargman, Yan Xia, Rebecca T. Ruck, Vincent J. Colandrea, John A. Howe, Nicole Buist, Andrew Nolting, Yongxin Han, Pinto Patrick A, Thomas Bara, Mark Cartwright, Robert Chase, Martin C. Clasby, Srikanth Venkatraman, Randy R. Miller, Keith Eagen, Samuel Chackalamannil, Josien Hubert B, Chad Bennett, Mariappan V. Chelliah, Ian W. Davies, Austin Chen, Shah Unmesh G, Sony Agrawal, Dipshikha Biswas, Jin Wu, Aileen Soriano
Publikováno v:
ACS medicinal chemistry letters. 7(1)
We have been focused on identifying a structurally different next generation inhibitor to MK-5172 (our Ns3/4a protease inhibitor currently under regulatory review), which would achieve superior pangenotypic activity with acceptable safety and pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e00f3c3f4a58b31fcc5937b720a0e8
https://pubmed.ncbi.nlm.nih.gov/26819676
https://pubmed.ncbi.nlm.nih.gov/26819676
The increased worldwide prevalence of diabetes mellitus (DM) in recent decades has been accompanied by an increase in the number of available pharmacologic therapies used to treat the disease. Differentiation of the available drugs is therefore an im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::400bccd28278826d146246a042e590da
https://doi.org/10.1039/9781849735322-00177
https://doi.org/10.1039/9781849735322-00177
Autor:
Shah Unmesh G, Timothy J. Kowalski
Type 2 diabetes (T2D) has reached epidemic proportions, and there is an unmet medical need for orally effective agents that regulate glucose homeostasis. GPR119, a class-A (rhodopsin-like) G protein-coupled receptor expressed primarily in the pancrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab35adae39670e7e9c14be4a79ec70c6
https://doi.org/10.1016/b978-0-12-381517-0.00016-3
https://doi.org/10.1016/b978-0-12-381517-0.00016-3
Autor:
Shah Unmesh G, Giuseppe Terracina, Julie Lee, Craig D. Boyle, Lili Zhang, Hana E. Baker, Timothy J. Kowalski, Samuel Chackalamannil
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(5)
Inhibition of 11β-HSD1 has demonstrated potential in the treatment of various components of metabolic syndrome. We wish to report herein the discovery of novel azabicyclic sulfonamide based 11β-HSD1 inhibitors. Highly potent compounds exhibiting in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bae61a43b81205440bfac735dcc8e63
https://pubmed.ncbi.nlm.nih.gov/20149650
https://pubmed.ncbi.nlm.nih.gov/20149650