Amorphous Formulation and in Vitro Performance Testing of Instantly Disintegrating Buccal Tablets for the Emergency Delivery of Naloxone

Autor: Ben Forbes, Elizabeth Allen, James Rickard, Shagufta Ahmed, Paul G. Royall, Christopher Holt, Abdulmalik Alqurshi, Zahrae Kumar, Rebecca Stansfield, David Taylor, John Strang, Verity Sandhu, Asma B. M. Buanz, Rebecca McDonald, Peter Cameron

Publikováno v: Alqurshi, A, Kumar, Z, McDonald, R, Strang, J, Buanz, A, Ahmed, S, Allen, E, Cameron, P, Rickard, J A, Sandhu, V, Holt, C, Stansfield, R, Taylor, D, Forbes, B & Royall, P G 2016, ' Amorphous Formulation and in Vitro Performance Testing of Instantly Disintegrating Buccal Tablets for the Emergency Delivery of Naloxone ', Molecular Pharmaceutics, vol. 13, no. 5, pp. 1688-1698 . https://doi.org/10.1021/acs.molpharmaceut.6b00096

The aim of this study was to develop a freeze-dried buccal tablet for the rapid delivery of naloxone in opioid overdose. The tablet composition was optimized to produce an amorphous matrix, which was confirmed by the absence of peaks associated with

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https://doi.org/10.1021/acs.molpharmaceut.6b00096