Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Shaghayegh Farhangmehr"'
Autor:
Syed Nabeel-Shah, Shuye Pu, Giovanni L. Burke, Nujhat Ahmed, Ulrich Braunschweig, Shaghayegh Farhangmehr, Hyunmin Lee, Mingkun Wu, Zuyao Ni, Hua Tang, Guoqing Zhong, Edyta Marcon, Zhaolei Zhang, Benjamin J. Blencowe, Jack F. Greenblatt
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-34 (2024)
Abstract Background N6-methyladenosine (m6A), the most abundant internal modification on eukaryotic mRNA, and N6, 2′-O-dimethyladenosine (m6Am), are epitranscriptomic marks that function in multiple aspects of posttranscriptional regulation. Fat ma
Externí odkaz:
https://doaj.org/article/4328bd3f4ab2479fba71d2541dde57fd
Autor:
Andrew J. Best, Ulrich Braunschweig, Mingkun Wu, Shaghayegh Farhangmehr, Adrian Pasculescu, Justin J. Lim, Lim Caden Comsa, Mark Jen, Jenny Wang, Alessandro Datti, Jeffrey L. Wrana, Sabine P. Cordes, Rima Al-awar, Hong Han, Benjamin J. Blencowe
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Disruption of alternative splicing frequently causes or contributes to human diseases and disorders. Consequently, there is a need for efficient and sensitive reporter assays capable of screening chemical libraries for compounds with efficac
Externí odkaz:
https://doaj.org/article/bdd3329af36c492bb7c45d82dc1c1b13
Autor:
Syed Nabeel-Shah, Hyunmin Lee, Nujhat Ahmed, Giovanni L. Burke, Shaghayegh Farhangmehr, Kanwal Ashraf, Shuye Pu, Ulrich Braunschweig, Guoqing Zhong, Hong Wei, Hua Tang, Jianyi Yang, Edyta Marcon, Benjamin J. Blencowe, Zhaolei Zhang, Jack F. Greenblatt
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103562- (2022)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein is essential for viral replication, making it a promising target for antiviral drug and vaccine development. SARS-CoV-2 infected patients exhibit an uncoor
Externí odkaz:
https://doaj.org/article/71c0d267688a465ca9051e412cc3eba6
Autor:
Faezeh Darki, Sahba Fekri, Shaghayegh Farhangmehr, Hamid Ahmadieh, Mohammad Hossein Dehghan, Elahe Elahi
Publikováno v:
Journal of Current Ophthalmology, Vol 31, Iss 2, Pp 172-179 (2019)
Purpose: To report the genetic analysis of an Iranian Bietti crystalline dystrophy (BCD)-affected family, and to review previously reported mutations in the gene and assess the distribution of affected amino acids in the encoded protein. Methods: The
Externí odkaz:
https://doaj.org/article/1a3a53e1739f4a9bb0e120fb798571fb
Autor:
Shaghayegh Farhangmehr, Syed Nabeel-Shah, Shuye Pu, Benjamin J. Blencowe, Nitoiu A, Ulrich Braunschweig, Jack Greenblatt
Cys2His2 (C2H2) type zinc finger (ZnF) proteins constitute a large class of proteins that are generally considered to be DNA-binding transcription factors. Using affinity purification followed by mass spectrometry, as well as reciprocal co-immunoprec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e604801795bd1953381e114037af7076
https://doi.org/10.1101/2021.09.29.462476
https://doi.org/10.1101/2021.09.29.462476
Autor:
Carlos Villacorta-Martin, Shaghayegh Farhangmehr, Ryan M. Hekman, Mohsan Saeed, Carlos Perea-Resa, Robert A. Davey, Andrew Emili, Jian Zhao, Peter E.A. Ash, Raghuveera Kumar Goel, Benjamin C. Blum, Andrew A. Wilson, Benjamin J. Blencowe, Ulrich Braunschweig, Benjamin Wolozin, Andrew Tilston-Lunel, Darrell N. Kotton, Ji-Xin Cheng, Avik Basu, Alexandra Mora-Martin, Esther Bullitt, Rhiannon B. Werder, Mark E. McComb, Dmitry A. Kretov, Dzmitry Padhorny, Sandeep Ojha, Shawn M. Lyons, Konstantinos D. Alysandratos, Jessie Huang, Anne Hinds, Valentina Perissi, J. J. Patten, Ahmed Youssef, Xaralabos Varelas, John H Connor, Dima Kozakov, Mamta Verma, Dante Bolzan, Indranil Paul, Ellen L Suder, Eric J. Burks, Matthew D. Layne, Elke Mühlberger, Stefan Wuchty, Adam J. Hume, Daniel Cifuentes, Sadhna Phanse, Julian H. Kwan, Michael D. Blower, Kristine M. Abo
Publikováno v:
Molecular Cell
Human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causative pathogen of the COVID-19 pandemic, exerts a massive health and socioeconomic crisis. The virus infects alveolar epithelial type 2 cells (AT2s), leading to l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469deb34c0395f965c7f17d2e99c8022
Autor:
Hyunmin Lee, Giovanni L Burke, Hua Tang, Kanwal Ashraf, Hong Wei, Guoqing Zhong, Shuye Pu, Benjamin J. Blencowe, Shaghayegh Farhangmehr, Edyta Marcon, Jack Greenblatt, Syed Nabeel-Shah, Jianyi Yang, Nujhat Ahmed, Zhaolei Zhang
The COVID-19 pandemic has caused over one million deaths thus far. There is an urgent need for the development of specific viral therapeutics and a vaccine. SARS-CoV-2 nucleocapsid (N) protein is highly expressed upon infection and is essential for v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68473a3240c30de559835b8e07042c77
https://doi.org/10.1101/2020.10.23.342113
https://doi.org/10.1101/2020.10.23.342113
Autor:
Michael Aregger, Chad L. Myers, Maximilian Billmann, Kevin R. Brown, Jason Moffat, Ulrich Braunschweig, Thomas Gonatopoulos-Pournatzis, Alexander Weiss, Tanja Durbic, Shaghayegh Farhangmehr, Kevin C.H. Ha, Henry N. Ward, Benjamin J. Blencowe
Publikováno v:
Nature biotechnology. 38(5)
Systematic mapping of genetic interactions (GIs) and interrogation of the functions of sizable genomic segments in mammalian cells represent important goals of biomedical research. To advance these goals, we present a CRISPR (clustered regularly inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de098378ae22101a663d4bef7e7cce57
https://pubmed.ncbi.nlm.nih.gov/32235908
https://pubmed.ncbi.nlm.nih.gov/32235908
Autor:
Xinyi Liang, Shen Zhang, Thomas Gonatopoulos-Pournatzis, Sabine P. Cordes, Manuel Irimia, Anne-Claude Gingras, Nahum Sonenberg, Mathieu Quesnel-Vallières, Shaghayegh Farhangmehr, Julie D. Forman-Kay, Graham L. Collingridge, Jon Permanyer, Ulrich Braunschweig, John Georgiou, Rieko Niibori, Stefan Maier, Melanie A. Woodin, Tyler Henderson, Eesha Sharma, Jonathan Roth, Brian Tsang, Benjamin J. Blencowe, Robert J. Weatheritt, Eric W Salter
Publikováno v:
Molecular Cell. 77:1176-1192.e16
Microexons represent the most highly conserved class of alternative splicing, yet their functions are poorly understood. Here, we focus on closely related neuronal microexons overlapping prion-like domains in the translation initiation factors, eIF4G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b42bfbaf05731ae6fb5b7cb23026d12
https://doi.org/10.1016/j.molcel.2020.01.006
https://doi.org/10.1016/j.molcel.2020.01.006