Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shafi M. Kuchay"'
Autor:
Shafi M. Kuchay, Ira M. Herman, Premanand Sundivakkam, Stacey E. Seidl, Chinnaswamy Tiruppathi, Kaori H. Yamada, Imran Chishti, Dorothy A. Kozlowski, Steven Lance, Adam J. Wieschhaus, Athar H. Chishti
Calpains are calcium-regulated cysteine proteases that have been implicated in the regulation of cell death pathways. Here, we used our calpain-1 null mouse model to evaluate the function of calpain-1 in neural degeneration following a rodent model o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f527866c0a5df429166059587554c36
Autor:
Anthony C. Kim, Anwar A. Khan, Anna Huttenlocher, Shafi M. Kuchay, Emily J. Welch, Brendan J. Quinn, Mary A. Lokuta, Athar H. Chishti
Publikováno v:
Proceedings of the National Academy of Sciences. 106:19842-19847
As mediators of innate immunity, neutrophils respond to chemoattractants by adopting a highly polarized morphology. Efficient chemotaxis requires the formation of one prominent pseudopod at the cell front characterized by actin polymerization, while
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee3109856d5966aa0dbe5d9e98ccabc
https://doi.org/10.1073/pnas.0906761106
https://doi.org/10.1073/pnas.0906761106
Autor:
Jianning Wei, Athar H. Chishti, Di Sha, Jang-Yen Wu, Chun Hua Lin, Ying Jin, Yi Hsuan Lee, Chandana Buddhala, Shafi M. Kuchay, Heng Wu
Publikováno v:
Brain Research. 1207:9-18
Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme for gamma-aminobutyric acid (GABA) biosynthesis. Previously, we reported the presence of truncated forms of GAD in vivo and in vitro. In addition, an unidentified endogenous protease respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b20020cf95a250b5bbfb2bdcbd11b9b
https://doi.org/10.1016/j.brainres.2008.02.033
https://doi.org/10.1016/j.brainres.2008.02.033
Publikováno v:
Molecular and Cellular Biology. 27:6038-6052
Calpains are ubiquitous calcium-regulated cysteine proteases that have been implicated in cytoskeletal organization, cell proliferation, apoptosis, cell motility, and hemostasis. Gene targeting was used to evaluate the physiological function of mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df3be3c92906389e1b69a2e8ecc1f31
https://doi.org/10.1128/mcb.00522-07
https://doi.org/10.1128/mcb.00522-07
Autor:
András Mádi, Zsolt Sarang, Gennaro Melino, Michael O. Glocker, Zsuzsa Szondy, Athar H. Chishti, Shafi M. Kuchay, Cornelia Koy, László Fésüs, S. Varga, David S. Ucker
Publikováno v:
Cell Death & Differentiation. 14:1842-1844
Tissue transglutaminase (TG2) facilitates phosphatidylserine exposure and calpain activity in calcium-induced death of erythrocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43921e1f7c7a8bcb5f0ab66277dab4c4
https://doi.org/10.1038/sj.cdd.4402193
https://doi.org/10.1038/sj.cdd.4402193
To cite this article: Kuchay SM, Wieschhaus AJ, Marinkovic M, Herman IM, Chishti AH. Targeted gene inactivation reveals a functional role of Calpain-1 in platelet spreading. J Thromb Haemost 2012; 10: 1120–32. Summary. Background: Calpains are impl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b817c5a2309905bd1a66723ddeaf9b6b
https://europepmc.org/articles/PMC3956748/
https://europepmc.org/articles/PMC3956748/
Autor:
Athar H. Chishti, Shafi M. Kuchay
Publikováno v:
Current opinion in hematology. 14(3)
Purpose of review There is considerable interest in understanding the function and mechanism of calpains in platelet aggregation, spreading, and granular secretion pathways. Recent insights from the calpain-1 knockout platelets suggest a pivotal role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7dd0335f37d843bc10e171f4edcc341
https://pubmed.ncbi.nlm.nih.gov/17414215
https://pubmed.ncbi.nlm.nih.gov/17414215
Publikováno v:
Neurobiology of learning and memory. 84(3)
We previously proposed the hypothesis that calpain activation played an important role in long-term potentiation (LTP) of synaptic transmission in hippocampus. Two forms of calpain are predominant in brain tissues, calpain 1 (mu-calpain), activated b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6cc3887f6db46a8c6114a4d20fccbea
https://pubmed.ncbi.nlm.nih.gov/16150618
https://pubmed.ncbi.nlm.nih.gov/16150618
Publikováno v:
Blood. 108:396-396
Calpains are ubiquitous calcium-regulated cysteine proteases that have been implicated in cytoskeletal organization, cell proliferation, apoptosis, cell motility, and hemostasis. Previously we used gene-targeting to evaluate the physiological functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6261233d2a8f56f2cc9b8e6f8cf2343d
https://doi.org/10.1182/blood.v108.11.396.396
https://doi.org/10.1182/blood.v108.11.396.396
Publikováno v:
Blood. 104:1268-1268
Calpains are ubiquitous calcium-regulated cysteine proteases that have been implicated in cytoskeletal organization, homeostasis, cell proliferation, cell motility, and apoptosis. The conventional calpains include mu-calpain (calpain I) that requires
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e53b517f2d9283b9a0544d4f0e97181
https://doi.org/10.1182/blood.v104.11.1268.1268
https://doi.org/10.1182/blood.v104.11.1268.1268