p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models.

Autor: Grow EJ; Howard Hughes Medical Institute, Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Weaver BD; Howard Hughes Medical Institute, Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Smith CM; Howard Hughes Medical Institute, Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Guo J; Howard Hughes Medical Institute, Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA., Stein P; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Shadle SC; Howard Hughes Medical Institute, Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Hendrickson PG; Howard Hughes Medical Institute, Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Johnson NE; Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA., Butterfield RJ; Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA., Menafra R; Leiden Genome Technology Center, Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Kloet SL; Leiden Genome Technology Center, Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., van der Maarel SM; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Williams CJ; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Cairns BR; Howard Hughes Medical Institute, Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA. bradley.cairns@hci.utah.edu.

Publikováno v: Nature genetics [Nat Genet] 2021 Aug; Vol. 53 (8), pp. 1207-1220. Date of Electronic Publication: 2021 Jul 15.

DUX4 Suppresses MHC Class I to Promote Cancer Immune Evasion and Resistance to Checkpoint Blockade.

Autor: Chew GL; Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Campbell AE; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., De Neef E; Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Sutliff NA; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Shadle SC; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA., Tapscott SJ; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Neurology, University of Washington, Seattle, WA 98195, USA. Electronic address: stapscot@fredhutch.org., Bradley RK; Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address: rbradley@fredhutch.org.

Publikováno v: Developmental cell [Dev Cell] 2019 Sep 09; Vol. 50 (5), pp. 658-671.e7. Date of Electronic Publication: 2019 Jul 18.

NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins.

Autor: Campbell AE; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, United States., Shadle SC; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, United States.; Molecular and Cellular Biology Program, University of Washington, Seattle, United States., Jagannathan S; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, United States.; Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States.; Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States., Lim JW; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, United States., Resnick R; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, United States.; Molecular and Cellular Biology Program, University of Washington, Seattle, United States.; Medical Scientist Training Program, University of Washington, Seattle, United States., Tawil R; Department of Neurology, University of Rochester Medical Center, Rochester, United States., van der Maarel SM; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands., Tapscott SJ; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, United States.; Department of Neurology, University of Washington, Seattle, United States.

Publikováno v: ELife [Elife] 2018 Mar 13; Vol. 7. Date of Electronic Publication: 2018 Mar 13.

DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy.

Autor: Shadle SC; Molecular and Cellular Biology Program, University of Washington, Seattle, Washington, United States of America.; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Zhong JW; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Campbell AE; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Conerly ML; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Jagannathan S; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.; Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Wong CJ; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Morello TD; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., van der Maarel SM; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands., Tapscott SJ; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

Publikováno v: PLoS genetics [PLoS Genet] 2017 Mar 08; Vol. 13 (3), pp. e1006658. Date of Electronic Publication: 2017 Mar 08 (Print Publication: 2017).