YAP mediates HIV-related liver fibrosis

Autor: Volney A. Spalding, Brian A. Fellenstein, James Ahodantin, Andre J. Jeyarajan, Yongtao Wang, Sanjoy K. Khan, Min Xu, Wenyu Lin, Nadia Alatrakchi, Lishan Su, Raymond T. Chung, Shadi Salloum

Publikováno v: JHEP Reports, Vol 6, Iss 11, Pp 101163- (2024)

Background & Aims: HIV accelerates liver fibrosis attributable to multiple etiologies, including HCV, HBV, and steatotic liver disease. Evidence also suggests that HIV infection itself is associated with liver fibrogenesis. Recent studies have implic

Externí odkaz: https://doaj.org/article/e74f747da88140ff9226da0f424d461b

Peroxidasin Deficiency Re-programs Macrophages Toward Pro-fibrolysis Function and Promotes Collagen Resolution in LiverSummary

Autor: Mozhdeh Sojoodi, Derek J. Erstad, Stephen C. Barrett, Shadi Salloum, Shijia Zhu, Tongqi Qian, Selene Colon, Eric M. Gale, Veronica Clavijo Jordan, Yongtao Wang, Shen Li, Bahar Ataeinia, Sasan Jalilifiroozinezhad, Michael Lanuti, Lawrence Zukerberg, Peter Caravan, Yujin Hoshida, Raymond T. Chung, Gautam Bhave, Georg M. Lauer, Bryan C. Fuchs, Kenneth K. Tanabe

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 5, Pp 1483-1509 (2022)

Background & Aims: During liver fibrosis, tissue repair mechanisms replace necrotic tissue with highly stabilized extracellular matrix proteins. Extracellular matrix stabilization influences the speed of tissue recovery. Here, we studied the expressi

Externí odkaz: https://doaj.org/article/6ba526f7c87641729036d4c0c5724ed3

LOXL-2 and TNC-C are markers of liver fibrogenesis in HCV/HIV-, HIV- and HCV-infected patients

Autor: Akif Altinbas, Jacinta A Holmes, Shadi Salloum, Anna Lidofsky, Nadia Alatrakchi, Ma Somsouk, Peter Hunt, Steven Deeks, Kara W Chew, Georg Lauer, Annie Kruger, Wenyu Lin, Raymond T Chung

Publikováno v: Biomarkers in Medicine. 16:839-846

Background: Lysil oxidase like enzyme-2 (LOXL-2) and TNC-C play important roles in organ fibrosis. We assessed circulating LOXL-2 and TNC-C levels and their relationship to fibrosis severity in HIV- and/or HCV-infected individuals. Methods: Healthy c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a31dfd88384b801e56906e290609116
https://doi.org/10.2217/bmm-2021-0596

Hepatitis B and Hepatitis C Virus Infection Promote Liver Fibrogenesis through a TGF-β1–Induced OCT4/Nanog Pathway

Autor: Wenting Li, Xiaoqiong Duan, Chuanlong Zhu, Xiao Liu, Andre J. Jeyarajan, Min Xu, Zeng Tu, Qiuju Sheng, Dong Chen, Chuanwu Zhu, Tuo Shao, Zhimeng Cheng, Shadi Salloum, Esperance A. Schaefer, Annie J. Kruger, Jacinta A. Holmes, Raymond T. Chung, Wenyu Lin

Publikováno v: J Immunol

Hepatitis B virus (HBV)/hepatitis C virus (HCV) coinfection accelerates liver fibrosis progression compared with HBV or HCV monoinfection. Octamer binding transcription factor 4 (OCT4) and Nanog are direct targets of the profibrogenic TGF-β1 signali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae23c513075e9796ba5c96c9ef8cfcbf
https://doi.org/10.4049/jimmunol.2001453

Fatty Acids Activate the Transcriptional Coactivator YAP1 to Promote Liver Fibrosis via p38 Mitogen-Activated Protein Kinase

Autor: Nadia Alatrakchi, Tuo Shao, Myung-Ho Kim, Wenyu Lin, Shadi Salloum, Raymond T. Chung, Annie J. Kruger, Andre J Jeyarajan, Kathleen E. Corey, Stuti Shroff, Andrew Kassa, Zhu Zhuo, Sanjoy K. Khan, Mozhdeh Sojoodi, Jacinta A Holmes, Esperance A. Schaefer

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1297-1310 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Patients with simple steatosis (SS) and nonalcoholic steatohepatitis can develop progressive liver fibrosis, which is associated with liver-related mortality. The mechanisms contributing to liver fibrosis development in SS, however,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e12cc853a36cd441fcfaf543a427312
http://www.sciencedirect.com/science/article/pii/S2352345X21001181