Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Shadeed, Gad"'
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2640 (2023)
Rosuvastatin (RSV) is a widely used cholesterol-lowering medication, but its limited bioavailability due to its susceptibility to stomach pH and extensive first-pass metabolism poses a significant challenge. A fast-dissolving film (FDF) formulation o
Externí odkaz:
https://doaj.org/article/4b5be52034934b2499cc18085d08c30c
Autor:
Mohamed F. Zaky, Taha M. Hammady, Shadeed Gad, Abdullah Alattar, Reem Alshaman, Ann Hegazy, Sawsan A. Zaitone, Mamdouh Mostafa Ghorab, Mohamed A. Megahed
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1668 (2023)
Nanostructured lipid carriers (NLCs) have been proven to significantly improve the bioavailability and efficacy of many drugs; however, they still have many limitations. These limitations could hinder their potential for enhancing the bioavailability
Externí odkaz:
https://doaj.org/article/a72bc50449cd4d46a4f90f0608c99f11
Autor:
Amr Selim Abu Lila, Mohammed Amran, Mohamed A. Tantawy, Ehssan H. Moglad, Shadeed Gad, Hadil Faris Alotaibi, Ahmad J. Obaidullah, El-Sayed Khafagy
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1755 (2023)
This study demonstrates high drug-loading of novel pyridine derivatives (S1–S4) in lipid- and polymer-based core–shell nanocapsules (LPNCs) for boosting the anticancer efficiency and alleviating toxicity of these novel pyridine derivatives. The n
Externí odkaz:
https://doaj.org/article/7216a9025034410095fb42ac382d4375
Autor:
Eman J. Heikal, Rashad M. Kaoud, Shadeed Gad, Hatem I. Mokhtar, Afaf A. Aldahish, Wafa Ali Alzlaiq, Sawsan A. Zaitone, Yasser M. Moustafa, Taha M. Hammady
Publikováno v:
Pharmaceuticals, Vol 16, Iss 6, p 795 (2023)
This study aimed to formulate a pharmaceutical dosage form containing omeprazole (OMP) and curcumin (CURC) to treat experimental peptic ulcers. OMP and CURC were preliminarily complexed with hydroxypropyl-β-cyclodextrin for enhancing their solubiliz
Externí odkaz:
https://doaj.org/article/d12c34129d0f4b4dab54acf700a4a816
Autor:
Eman J. Heikal, Rashad M. Kaoud, Shadeed Gad, Hatem I. Mokhtar, Abdullah Alattar, Reem Alshaman, Sawsan A. Zaitone, Yasser M. Moustafa, Taha M. Hammady
Publikováno v:
Gels, Vol 9, Iss 4, p 264 (2023)
This research aims to develop a drug delivery system that effectively treats colitis while administering curcumin/mesalamine by coating alginate/chitosan beads with Eudragit® S-100 to target the colon. Beads were tested to determine their physicoche
Externí odkaz:
https://doaj.org/article/e462dc0e1d7f4582b594099b8cef9525
Autor:
Mohamed F. Zaky, Mohamed A. Megahed, Taha M. Hammady, Shadeed Gad, Mamdouh Mostafa Ghorab, Khalid M. El-Say
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 80 (2022)
Apixaban (Apx), an oral anticoagulant drug, is a direct factor Xa inhibitor for the prophylaxis against venous thromboembolism. Apx has limited oral bioavailability and poor water solubility. The goal of this study was to improve the formulation of a
Externí odkaz:
https://doaj.org/article/6405b0c884324bf09cbab0b622bee553
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2268 (2022)
The objective of this study was to formulate and evaluate valsartan (VLT) ethosomes to prepare an optimized formula of VLT-entrapped ethosomes that could be incorporated into a sustained release transdermal gel dosage form. The formulation of the pre
Externí odkaz:
https://doaj.org/article/ba2dc52fc0ac488e81fad25d5dda7d1c
Autor:
Mohammed Amran, El-Sayed Khafagy, Hatem I. Mokhtar, Sawsan A. Zaitone, Yasser M. Moustafa, Shadeed Gad
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2354 (2022)
This work aimed to establish a simple method to produce additive-free triamcinolone acetonide (TAA) microspheres suitable for pulmonary delivery, and therefore more simple manufacturing steps will be warranted. The spray-drying process involved the o
Externí odkaz:
https://doaj.org/article/faf9a3b6481b4ab48c9d1cfe475716ce
Autor:
Ibrahim A. Mousa, Taha M. Hammady, Shadeed Gad, Sawsan A. Zaitone, Mohamed El-Sherbiny, Ossama M. Sayed
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 657 (2022)
To achieve the best treatment of skin cancer, drug penetration inside the deepest layers of the skin is an important scientific interest. We designed an ethosome formulation that serves as a carrier for metformin and measured the in vitro skin permea
Externí odkaz:
https://doaj.org/article/461471d1d49247739bed4ecb09a48cd6
Autor:
El-Sayed Khafagy, Amr S. Abu Lila, Nahed Mohamed Sallam, Rania Abdel-Basset Sanad, Mahgoub Mohamed Ahmed, Mamdouh Mostafa Ghorab, Hadil Faris Alotaibi, Ahmed Alalaiwe, Mohammed F. Aldawsari, Saad M. Alshahrani, Abdullah Alshetaili, Bjad K. Almutairy, Ahmed Al Saqr, Shadeed Gad
Publikováno v:
Gels, Vol 8, Iss 4, p 235 (2022)
Carvedilol (CRV) is a non-selective third generation beta-blocker used to treat hypertension, congestive heart failure and angina pectoris. Oral administration of CRV showed poor bioavailability (25%), which might be ascribed to its extensive first-p
Externí odkaz:
https://doaj.org/article/5a08d724a47c40cd83aa21f30b0e9139