LAG-3, TIM-3 and VISTA Expression on Tumor-Infiltrating Lymphocytes in Oropharyngeal Squamous Cell Carcinoma—Potential Biomarkers for Targeted Therapy Concepts

Autor: Nora Wuerdemann, Katharina Pütz, Hans Eckel, Rishabh Jain, Claus Wittekindt, Christian U. Huebbers, Shachi J. Sharma, Christine Langer, Stefan Gattenlöhner, Reinhard Büttner, Ernst-Jan Speel, Malte Suchan, Steffen Wagner, Alexander Quaas, Jens P. Klussmann

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 1, p 379 (2020)

Tumor growth and survival requires a particularly effective immunosuppressant tumor microenvironment (TME) to escape destruction by the immune system. While immunosuppressive checkpoint markers like programmed cell death 1 ligand (PD-L1) are already

Externí odkaz: https://doaj.org/article/5629dd4a34ac4603bb5a863ee45fa51f

Hypoxia-inducible factor-1α activation in HPV-positive head and neck squamous cell carcinoma cell lines

Autor: Jennifer, Knuth, Shachi J, Sharma, Nora, Würdemann, Claudia, Holler, Boyan K, Garvalov, Till, Acker, Claus, Wittekindt, Steffen, Wagner, Jens P, Klussmann

Publikováno v: Oncotarget

Purpose Human papillomavirus (HPV) is a causative agent for a rising number of head and neck squamous cell carcinomas (HNSCC), which are characterized by distinct tumor biology. Hypoxia inducible-factor (HIF) signaling influences initiation and progr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ac8d18fe73f0e64f4c84ccaa0097591
https://pubmed.ncbi.nlm.nih.gov/29163780

Upfront Surgery vs. Primary Chemoradiation in an Unselected, Bicentric Patient Cohort with Oropharyngeal Squamous Cell Carcinoma—A Matched-Pair Analysis.

Autor: Zimmermann, Philipp H.^1,2 (AUTHOR) philipp.zimmermann@uk-koeln.de, Stuut, Marijn^3,4 (AUTHOR) M.Stuut@mzh.nl, Wuerdemann, Nora^1,2,5 (AUTHOR) malte.suchan@uk-koeln.de, Möllenhoff, Kathrin^6,7 (AUTHOR) kathrin.moellenhoff@ruhr-uni-bochum.de, Suchan, Malte^1,2 (AUTHOR) hans.eckel@uk-koeln.de, Eckel, Hans^1,2 (AUTHOR) philipp.wolber@uk-koeln.de, Wolber, Philipp^1,2 (AUTHOR) Shachi.Sharma@uk-koeln.de, Sharma, Shachi J.^1,2,5 (AUTHOR) jens.klussmann@uk-koeln.de, Kämmerer, Fabian⁵ (AUTHOR) Steffen.Wagner@hno.med.uni-giessen.de, Langer, Christine⁵ (AUTHOR) bernd.kremer@mumc.nl, Wittekindt, Claus⁸ (AUTHOR) Claus.Wittekindt@klinikumdo.de, Wagner, Steffen⁵ (AUTHOR), Kremer, Bernd⁵ (AUTHOR), Speel, Ernst Jan M.⁹ (AUTHOR) ernstjan.speel@mumc.nl, Klussmann, Jens P.^1,2 (AUTHOR)

Publikováno v: Cancers. Nov2021, Vol. 13 Issue 21, p5265. 1p.

PD-L1 Expression and a High Tumor Infiltrate of CD8+ Lymphocytes Predict Outcome in Patients with Oropharyngeal Squamous Cells Carcinoma.

Autor: Wuerdemann, Nora^1,2,3 (AUTHOR) Claus.Wittekindt@klinikumdo.de, Gültekin, Sibel E.⁴ (AUTHOR) sibelg@gazi.edu.tr, Pütz, Katharina⁵ (AUTHOR) katharina.puetz@uk-koeln.de, Wittekindt, Claus¹ (AUTHOR) Shachi.Sharma@uk-koeln.de, Huebbers, Christian U.^2,3,6 (AUTHOR) hans.eckel@uk-koeln.de, Sharma, Shachi J.^1,2,3 (AUTHOR) b.schubotz@gmail.com, Eckel, Hans^2,3 (AUTHOR), Schubotz, Anna B.¹ (AUTHOR) Steffen.Wagner@hno.med.uni-giessen.de, Gattenlöhner, Stefan⁷ (AUTHOR) stefan.gattenloehner@patho.med.uni-giessen.de, Büttner, Reinhard⁵ (AUTHOR) reinhard.buettner@uk-koeln.de, Speel, Ernst-Jan⁸ (AUTHOR) ernstjan.speel@mumc.nl, Klussmann, Jens P.^2,3 (AUTHOR), Wagner, Steffen¹ (AUTHOR), Quaas, Alexander⁵ (AUTHOR) alexander.quaas@uk-koeln.de

Publikováno v: International Journal of Molecular Sciences. Aug2020, Vol. 21 Issue 15, p5228. 1p.

Praxis der Tumorendoskopie an deutschen HNO-Kliniken. (German)

Autor: Sharma, S. J., Linke, J. J., Kroll, T., Klußmann, J. P., Guntinas-Lichius, O., Wittekindt, C.

Publikováno v: Tumordiagnostik & Therapie; Jun2013, Vol. 34 Issue 4, p213-216, 4p