Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Shachar Shoshani"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Myotonic dystrophy type 1 (DM1) is a multisystemic disease caused by pathogenic expansions of CTG repeats. The expanded repeats are transcribed to long RNA and induce cellular toxicity. Recent studies suggest that the CUG repeats are processed by the
Externí odkaz:
https://doaj.org/article/163a605da10a42feb4d0bc663f7c0e5a
Autor:
Maya Braun, Shachar Shoshani, Joana Teixeira, Anna Mellul Shtern, Maya Miller, Zvi Granot, Sylvia E.J. Fischer, Susana M.D. A. Garcia, Yuval Tabach
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104246- (2022)
Summary: Nucleotide repeat expansions are a hallmark of over 40 neurodegenerative diseases and cause RNA toxicity and multisystemic symptoms that worsen with age. Through an unclear mechanism, RNA toxicity can trigger severe disease manifestation in
Externí odkaz:
https://doaj.org/article/d676fb5f1b654b059ca467422dae29ee
Publikováno v:
Toxins, Vol 13, Iss 12, p 910 (2021)
Pathologic expansions of DNA nucleotide tandem repeats may generate toxic RNA that triggers disease phenotypes. RNA toxicity is the hallmark of multiple expansion repeat disorders, including myotonic dystrophy type 1 (DM1). To date, there are no avai
Externí odkaz:
https://doaj.org/article/5377e373053e45a788539bd55cd8e722
Autor:
Maya, Braun, Shachar, Shoshani, Joana, Teixeira, Anna, Mellul Shtern, Maya, Miller, Zvi, Granot, Sylvia E J, Fischer, Susana M D A, Garcia, Yuval, Tabach
Publikováno v:
iScience. 25(5)
Nucleotide repeat expansions are a hallmark of over 40 neurodegenerative diseases and cause RNA toxicity and multisystemic symptoms that worsen with age. Through an unclear mechanism, RNA toxicity can trigger severe disease manifestation in infants i