Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Shachar Raz"'
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 12, Pp 1359-1370 (2009)
ABCG2 is an efflux transporter conferring multidrug resistance (MDR) on cancer cells. However, the initial molecular events leading to its up-regulation in MDR tumor cells are poorly understood. Herein, we explored the impact of drug treatment on the
Externí odkaz:
https://doaj.org/article/e4b727d835a5408d9d3713de4185954d
Publikováno v:
Journal of proteomics. 239
Folates are essential for nucleotide biosynthesis, amino acid metabolism and cellular proliferation. Following carrier-mediated uptake, folates are polyglutamylated by folylpoly-ɣ-glutamate synthetase (FPGS), resulting in their intracellular retenti
Autor:
Nikita Sarvin, Shachar Raz, Shoval Lagziel, Elina Aizenshtein, Won Dong Lee, Dzmitry Mukha, Keren Nevo-Dinur, Tomer Shlomi, Anna Chiara Pirona, Elazar Besser, Boris Sarvin, Alon Stern
Publikováno v:
Cell metabolism. 33(1)
Summary Folate metabolism supplies one-carbon (1C) units for biosynthesis and methylation and has long been a target for cancer chemotherapy. Mitochondrial serine catabolism is considered the sole contributor of folate-mediated 1C units in proliferat
Publikováno v:
Drug Resistance Updates. 28:43-64
Mammalians are devoid of autonomous biosynthesis of folates and hence must obtain them from the diet. Reduced folate cofactors are B9-vitamins which play a key role as donors of one-carbon units in the biosynthesis of purine nucleotides, thymidylate
Autor:
Godefridus J. Peters, Yehuda G. Assaraf, Gertjan J.L. Kaspers, Shachar Raz, Anna Wojtuszkiewicz, Gerrit Jansen, Michal Stark, Edwin Sonneveld, Jacqueline Cloos
Publikováno v:
International Journal of Cancer. 138:1645-1656
Methotrexate (MTX), a folate antagonist which blocks de novo nucleotide biosynthesis and DNA replication, is an anchor drug in acute lymphoblastic leukemia (ALL) treatment. However, drug resistance is a primary hindrance to curative chemotherapy in l
Publikováno v:
Oncotarget
Polyglutamylation of antifolates catalyzed by folylpoly-γ-glutamate synthetase (FPGS) is essential for their intracellular retention and cytotoxic activity. Hence, loss of FPGS expression and/or function results in lack of antifolate polyglutamylati
Autor:
Anna, Wojtuszkiewicz, Shachar, Raz, Michal, Stark, Yehuda G, Assaraf, Gerrit, Jansen, Godefridus J, Peters, Edwin, Sonneveld, Gertjan J L, Kaspers, Jacqueline, Cloos
Publikováno v:
International journal of cancer. 138(7)
Methotrexate (MTX), a folate antagonist which blocks de novo nucleotide biosynthesis and DNA replication, is an anchor drug in acute lymphoblastic leukemia (ALL) treatment. However, drug resistance is a primary hindrance to curative chemotherapy in l
Publikováno v:
Cancer Cell & Microenvironment.
Antifolates are important components of treatment regimens of hematological malignancies and solid tumors. Following cellular uptake, antifolates undergo polyglutamylation, catalyzed by the enzyme folylpoly-γ-glutamate synthetase (FPGS), which is cr
Publikováno v:
Cell Death & Disease
Antifolates have a crucial role in the treatment of various cancers by inhibiting key enzymes in purine and thymidylate biosynthesis. However, the frequent emergence of inherent and acquired antifolate resistance in solid tumors calls for the develop
Autor:
Edwin Sonneveld, Gerrit Jansen, Godefridus J. Peters, Gertjan J.L. Kaspers, Shachar Raz, Yehuda G. Assaraf, Anna Wojtuszkiewicz, Jacqueline Cloos, Michal Stark
Publikováno v:
Cancer Research. 73:4628-4628
The antifolate methotrexate (MTX) is used in acute lymphoblastic leukemia (ALL) treatment. Cellular retention and consequent efficacy of MTX is enhanced by polyglutamylation, a reaction catalyzed by folylpolyglutamate synthetase (FPGS). It has been s