Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Shabnam Shaabani"'
Autor:
Zefeng Wang, Shabnam Shaabani, Xiang Gao, Yuen Lam Dora Ng, Valeriia Sapozhnikova, Philipp Mertins, Jan Krönke, Alexander Dömling
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Thalidomide and its analogs are molecular glues (MGs) that lead to targeted ubiquitination and degradation of key cancer proteins via the cereblon (CRBN) E3 ligase. Here, we develop a direct-to-biology (D2B) approach for accelerated discover
Externí odkaz:
https://doaj.org/article/f92198598a504265983f5dc2bc34f074
Autor:
Yuequ Zhang, Shabnam Shaabani, Kirsty Vowinkel, Marina Trombetta-Lima, Angélica María Sabogal-Guáqueta, Tingting Chen, Jan Hoekstra, Jan Lembeck, Martina Schmidt, Niels Decher, Alexander Dömling, Amalia M. Dolga
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 171, Iss , Pp 116163- (2024)
Small conductance calcium-activated potassium (SK) channel activity has been proposed to play a role in the pathology of several neurological diseases. Besides regulating plasma membrane excitability, SK channel activation provides neuroprotection ag
Externí odkaz:
https://doaj.org/article/801196e2d22d464e8e87e27b4ea0434c
Autor:
Fatma B Rashidi, Alanod D Al-Qahtani, Sara S Bashraheel, Shabnam Shaabani, Matthew R Groves, Alexander Dömling, Sayed K Goda
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0294885 (2023)
[This corrects the article DOI: 10.1371/journal.pone.0196254.].
Externí odkaz:
https://doaj.org/article/0788b9a7df794377a0ef77b5090378e5
Autor:
Yuanze Wang, Shabnam Shaabani, Maryam Ahmadianmoghaddam, Li Gao, Ruixue Xu, Katarzyna Kurpiewska, Justyna Kalinowska-Tluscik, Joe Olechno, Richard Ellson, Michael Kossenjans, Victoria Helan, Matthew Groves, Alexander Dömling
Publikováno v:
ACS Central Science, Vol 5, Iss 3, Pp 451-457 (2019)
Externí odkaz:
https://doaj.org/article/ea2524a7f5c946ce9ffaddab56086d41
Autor:
Shabnam Shaabani, Louis Gadina, Ewa Surmiak, Zefeng Wang, Bidong Zhang, Roberto Butera, Tryfon Zarganes-Tzitzikas, Ismael Rodriguez, Justyna Kocik-Krol, Katarzyna Magiera-Mularz, Lukasz Skalniak, Alexander Dömling, Tad A. Holak
Publikováno v:
Molecules, Vol 27, Iss 11, p 3454 (2022)
New biphenyl-based chimeric compounds containing pomalidomide were developed and evaluated for their activity to inhibit and degrade the programmed cell death-1/programmed cell death- ligand 1 (PD-1/PD-L1) complex. Most of the compounds displayed exc
Externí odkaz:
https://doaj.org/article/67a2552841844f3d9aa8c069ce56167b
Autor:
Thomas GP Grünewald, Marta Alonso, Sofia Avnet, Ana Banito, Stefan Burdach, Florencia Cidre‐Aranaz, Gemma Di Pompo, Martin Distel, Heathcliff Dorado‐Garcia, Javier Garcia‐Castro, Laura González‐González, Agamemnon E Grigoriadis, Merve Kasan, Christian Koelsche, Manuela Krumbholz, Fernando Lecanda, Silvia Lemma, Dario L Longo, Claudia Madrigal‐Esquivel, Álvaro Morales‐Molina, Julian Musa, Shunya Ohmura, Benjamin Ory, Miguel Pereira‐Silva, Francesca Perut, Rene Rodriguez, Carolin Seeling, Nada Al Shaaili, Shabnam Shaabani, Kristina Shiavone, Snehadri Sinha, Eleni M Tomazou, Marcel Trautmann, Maria Vela, Yvonne MH Versleijen‐Jonkers, Julia Visgauss, Marta Zalacain, Sebastian J Schober, Andrej Lissat, William R English, Nicola Baldini, Dominique Heymann
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 11, Pp n/a-n/a (2020)
Abstract Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and compr
Externí odkaz:
https://doaj.org/article/32421af97ff64f339c73c8bfd6f57409
Publikováno v:
Frontiers in Chemistry, Vol 7 (2020)
Externí odkaz:
https://doaj.org/article/035a7ae470984efb8be83cafc3521de0
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
A novel, efficient and environmentally friendly approach has been developed for the synthesis of biologically important bis-heterocyclic oxazepine-quinazolinone derivatives. The structurally interesting compounds of high purity were synthesized by a
Externí odkaz:
https://doaj.org/article/c0e32b59aff74a8b925286036121d27d
Autor:
Fatma B Rashidi, Alanod D AlQhatani, Sara S Bashraheel, Shabnam Shaabani, Matthew R Groves, Alexander Dömling, Sayed K Goda
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196254 (2018)
Repeated cycles of antibody-directed enzyme pro-drug therapy (ADEPT) and the use of glucarpidase in the detoxification of cytotoxic methotrexate (MTX) are highly desirable during cancer therapy but are hampered by the induced human antibody response
Externí odkaz:
https://doaj.org/article/158380092fe9436bbdc32c79ea499cbc
Publikováno v:
Iranian Journal of Chemistry & Chemical Engineering, Vol 32, Iss 1, Pp 3-10 (2013)
Benzazolo [2,1-b]quinazolinones and triazolo[2,1-b]quinazolinones were synthesized in high yields by the condensation reaction of an aldehyde and a cyclic β-diketone with 2 - aminobenzimidazole, 2 - aminobenzothiazole or 1, 2, 4 - triazole derivativ
Externí odkaz:
https://doaj.org/article/0beb4f649df7459da5af4e557ee41d4f