Histological Changes in the Urothelium and Suburothelium of Human Overactive Bladder following Intradetrusor Injections of Botulinum Neurotoxin Type A for the Treatment of Neurogenic or Idiopathic Detrusor Overactivity

Autor: Clare J. Fowler, Alex Freeman, Apostolos Apostolidis, G. Gonzales, Thomas S. Jacques, Vinay Kalsi, Prokar Dasgupta, Shabnam Ghazi-Noori, Soumendra N. Datta, R Popat, Sohier Elneil

Publikováno v: European Urology. 53:1245-1253

Background We examined, for the first time in a prospective study, the histological changes in the urothelium and suburothelium of patients with neurogenic (NDO) or idiopathic detrusor overactivity (IDO) after one or repeat treatments with intradetru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48394fdb529178187afc16bc98da1567
https://doi.org/10.1016/j.eururo.2008.02.037

FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration

Autor: Stuart Pickering-Brown, William W. Seeley, Neill R. Graff-Radford, Jonathan D. Rohrer, Keith A. Josephs, John Collinge, David G. Munoz, Adrian M. Isaacs, Christine Van Broeckhoven, Harro Seelaar, Vivianna M. Van Deerlin, Ronald C. Petersen, Samir Kumar-Singh, John C. van Swieten, Simon Mead, Jeremy M Brown, Hazel Urwin, Han Xiang Deng, Joseph E. Parisi, Dennis W. Dickson, Astrid Authier, Peter Johannsen, Elizabeth M. C. Fisher, Charles L. White, David M. A. Mann, Ida E. Holm, Sebastiaan Engelborghs, Janice L. Holton, Ian R. A. Mackenzie, Shabnam Ghazi-Noori, Jørgen E. Nielsen, Martin N. Rossor, Gary Adamson, Bruce L. Miller, Manuela Neumann, Kimmo J. Hatanpaa, Jillian J. Kril, Tamas Revesz, Felix Geser, Rosa Rademakers, Julie van der Zee, Glenda M. Halliday, Eileen H. Bigio, John Q. Trojanowski, Myron F. Weiner, Peter Paul De Deyn, Valerie Doodeman

Publikováno v: Urwin, H, Josephs, K A, Rohrer, J D, Mackenzie, I R, Neumann, M, Authier, A, Seelaar, H, van Swieten, J C, Brown, J M, Johannsen, P, Nielsen, J E, Holm, I E, Dickson, D W, Rademakers, R, Graff-Radford, N R, Parisi, J E, Petersen, R C, Hatanpaa, K J, White, C L, Weiner, M F, Geser, F, Van Deerlin, V M, Trojanowski, J Q, Miller, B L, Seeley, W W, van der Zee, J, Kumar-Singh, S, Engelborghs, S, de Deyn, P P, Van Broeckhoven, C, Bigio, E H, Deng, H X, Halliday, G M, Kril, J J, Munoz, D G, Mann, D M, Pickering-Brown, S M, Doodeman, V D, Adamson, G, Ghazi-Noori, S, Fisher, E M C, Holton, J L, Revesz, T, Rossor, M N, Collinge, J, Mead, S & Isaacs, A M 2010, ' FUS pathology defines the majority of tau-and TDP-43-negative frontotemporal lobar degeneration ', Acta Neuropathologica, vol. 120, no. 1, pp. 33-41 . https://doi.org/10.1007/s00401-010-0698-6
Acta Neuropathologica, 120(1), 33-41. Springer Verlag
Acta Neuropathologica, 120(1), 33-41. Springer-Verlag
Acta neuropathologica
Acta Neuropathologica

Through an international consortium, we have collected 37 tau- and TAR DNA-binding protein 43 (TDP-43)-negative frontotemporal lobar degeneration (FTLD) cases, and present here the first comprehensive analysis of these cases in terms of neuropatholog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c545424334d583222f2b1385ef39ff
https://research.vumc.nl/ws/files/760631/261890.pdf

Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease

Autor: Xiao-Jiang Li, James M. Olson, Caroline L. Benn, Jang Ho J. Cha, Shabnam Ghazi-Noori, He Li, Gillian P. Bates, Paul T. Sharpe, Syed M N N Faruque, Ben Woodman, Christian Landles, Shihua Li, Emma Hockly, Kirupa Sathasivam, Andrew D. Strand

Publikováno v: Human molecular genetics. 14(20)

In postmortem Huntington's disease brains, mutant htt is present in both nuclear and cytoplasmic compartments. To dissect the impact of nuclear and extranuclear mutant htt on the initiation and progression of disease, we generated a series of transge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3414ba8a56ce5ba9abb9643c912aacf5
https://pubmed.ncbi.nlm.nih.gov/16183657

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

Autor: J.L. Marsh, Shabnam Ghazi-Noori, Gillian P. Bates, Kirupa Sathasivam, Victoria M. Richon, Leslie M. Thompson, Xianbo Zhou, Donna L. Smith, Amarbirpal Mahal, Cathryn M. Lewis, Paul A. Marks, Emma Hockly, Philip A. S. Lowden, Joan S. Steffan, E. Rosa, Benjamin Woodman

Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused by a CAG/polyglutamine repeat expansion and for which there is no effective therapy. Recent evidence indicates that transcriptional dysregulation may contribu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5925ffc4d9dfa1f68b14994e20537c5
https://europepmc.org/articles/PMC149955/

Minocycline and doxycycline are not beneficial in a model of Huntington's disease.

Autor: Donna L. Smith, Benjamin Woodman, Amarbirpal Mahal, Kirupa Sathasivam, Shabnam Ghazi-Noori, Philip A. S. Lowden, Gillian P. Bates, Emma Hockly

Publikováno v: Annals of Neurology; Aug2003, Vol. 54 Issue 2, p186-196, 11p