Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Shabeesh Balan"'
Autor:
Tomonori Hara, Manabu Toyoshima, Yasuko Hisano, Shabeesh Balan, Yoshimi Iwayama, Harumi Aono, Yushi Futamura, Hiroyuki Osada, Yuji Owada, Takeo Yoshikawa
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Carbonyl stress, a specific form of oxidative stress, is reported to be involved in the pathophysiology of schizophrenia; however, little is known regarding the underlying mechanism. Here, we found that disruption of GLO1, the gene encoding
Externí odkaz:
https://doaj.org/article/a5cc49e3b8d54d4a818d9847431f0860
Autor:
Yoneko Hayase, Shigeru Amano, Koichi Hashizume, Takashi Tominaga, Hiroyuki Miyamoto, Yukie Kanno, Yukiko Ueno-Inoue, Takayoshi Inoue, Mayumi Yamada, Shigehiro Ogata, Shabeesh Balan, Ken Hayashi, Yoshiki Miura, Kentaro Tokudome, Yukihiro Ohno, Takuma Nishijo, Toshihiko Momiyama, Yuchio Yanagawa, Akiko Takizawa, Tomoji Mashimo, Tadao Serikawa, Akihiro Sekine, Eiji Nakagawa, Eri Takeshita, Takeo Yoshikawa, Chikako Waga, Ken Inoue, Yu-ichi Goto, Yoichi Nabeshima, Nobuo Ihara, Kazuhiro Yamakawa, Shinichiro Taya, Mikio Hoshino
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-17 (2020)
Abstract The Ihara epileptic rat (IER) is a mutant model with limbic-like seizures whose pathology and causative gene remain elusive. In this report, via linkage analysis, we identified Down syndrome cell adhesion molecule-like 1(Dscaml1) as the resp
Externí odkaz:
https://doaj.org/article/83b2c846e60840adb9d55f24ef0bdf26
Autor:
Tetsuo Ohnishi, Shabeesh Balan, Manabu Toyoshima, Motoko Maekawa, Hisako Ohba, Akiko Watanabe, Yoshimi Iwayama, Yuko Fujita, Yunfei Tan, Yasuko Hisano, Chie Shimamoto-Mitsuyama, Yayoi Nozaki, Kayoko Esaki, Atsuko Nagaoka, Junya Matsumoto, Mizuki Hino, Nobuko Mataga, Akiko Hayashi-Takagi, Kenji Hashimoto, Yasuto Kunii, Akiyoshi Kakita, Hirooki Yabe, Takeo Yoshikawa
Publikováno v:
EBioMedicine, Vol 45, Iss , Pp 432-446 (2019)
Background: Betaine is known to act against various biological stresses and its levels were reported to be decreased in schizophrenia patients. We aimed to test the role of betaine in schizophrenia pathophysiology, and to evaluate its potential as a
Externí odkaz:
https://doaj.org/article/8e044d4f4b674d4db13d08c405718559
Autor:
Tetsuo Ohnishi, Yuji Kiyama, Fumiko Arima‐Yoshida, Mitsutaka Kadota, Tomoe Ichikawa, Kazuyuki Yamada, Akiko Watanabe, Hisako Ohba, Kaori Tanaka, Akihiro Nakaya, Yasue Horiuchi, Yoshimi Iwayama, Manabu Toyoshima, Itone Ogawa, Chie Shimamoto‐Mitsuyama, Motoko Maekawa, Shabeesh Balan, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Yayoi Nozaki, Rumi Kurokawa, Kazuhiro Suzuki, Akane Yoshikawa, Tomoko Toyota, Toshihiko Hosoya, Hiroyuki Okuno, Haruhiko Bito, Masanari Itokawa, Shigehiro Kuraku, Toshiya Manabe, Takeo Yoshikawa
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)
Abstract Genomic defects with large effect size can help elucidate unknown pathologic architecture of mental disorders. We previously reported on a patient with schizophrenia and a balanced translocation between chromosomes 4 and 13 and found that th
Externí odkaz:
https://doaj.org/article/c3d643b8363c4222821faa0e5c5dffd8
Autor:
Yuina Wada, Motoko Maekawa, Tetsuo Ohnishi, Shabeesh Balan, Shigeru Matsuoka, Kazuya Iwamoto, Yoshimi Iwayama, Hisako Ohba, Akiko Watanabe, Yasuko Hisano, Yayoi Nozaki, Tomoko Toyota, Tomomi Shimogori, Masanari Itokawa, Tetsuyuki Kobayashi, Takeo Yoshikawa
Publikováno v:
EBioMedicine, Vol 62, Iss , Pp 103130- (2020)
Background: The pathophysiology of schizophrenia, a major psychiatric disorder, remains elusive. In this study, the role of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor (RXR) families, belonging to the ligand-activated nuclea
Externí odkaz:
https://doaj.org/article/053df848fe4f4336aea9c67b654ae3f7
Autor:
Masayuki Ide, Tetsuo Ohnishi, Manabu Toyoshima, Shabeesh Balan, Motoko Maekawa, Chie Shimamoto‐Mitsuyama, Yoshimi Iwayama, Hisako Ohba, Akiko Watanabe, Takashi Ishii, Norihiro Shibuya, Yuka Kimura, Yasuko Hisano, Yui Murata, Tomonori Hara, Momo Morikawa, Kenji Hashimoto, Yayoi Nozaki, Tomoko Toyota, Yuina Wada, Yosuke Tanaka, Tadafumi Kato, Akinori Nishi, Shigeyoshi Fujisawa, Hideyuki Okano, Masanari Itokawa, Nobutaka Hirokawa, Yasuto Kunii, Akiyoshi Kakita, Hirooki Yabe, Kazuya Iwamoto, Kohji Meno, Takuya Katagiri, Brian Dean, Kazuhiko Uchida, Hideo Kimura, Takeo Yoshikawa
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 12, Pp n/a-n/a (2019)
Abstract Mice with the C3H background show greater behavioral propensity for schizophrenia, including lower prepulse inhibition (PPI), than C57BL/6 (B6) mice. To characterize as‐yet‐unknown pathophysiologies of schizophrenia, we undertook proteom
Externí odkaz:
https://doaj.org/article/7d421ed9c97e4545be1c2101a84acaa4
Publikováno v:
Neurobiology of Disease, Vol 131, Iss , Pp - (2019)
Schizophrenia is one of the leading causes of disability among mental disorders, contributing to a substantial socioeconomic burden. Our understanding of the mechanisms of the pathogenesis of the disease has largely been limited by its inherent compl
Externí odkaz:
https://doaj.org/article/22151d5580984c758c976379785ac797
Autor:
Shabeesh Balan, Sumitha Prameela Bharathan, Neetha Nanoth Vellichiramal, Sanish Sathyan, Vijai Joseph, Kurupath Radhakrishnan, Moinak Banerjee
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89253 (2014)
Epilepsy constitutes a heterogeneous group of disorders that is characterized by recurrent unprovoked seizures due to widely different etiologies. Multidrug resistance remains a major issue in clinical epileptology, where one third of patients with e
Externí odkaz:
https://doaj.org/article/1cf86b156a394d63a5d6d751160ae32b
Autor:
Shabeesh Balan, Kazuo Yamada, Eiji Hattori, Yoshimi Iwayama, Tomoko Toyota, Tetsuo Ohnishi, Motoko Maekawa, Manabu Toyoshima, Yasuhide Iwata, Katsuaki Suzuki, Mitsuru Kikuchi, Takeo Yoshikawa
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70302 (2013)
The post-synaptic density (PSD) of glutamatergic synapses harbors a multitude of proteins critical for maintaining synaptic dynamics. Alteration of protein expression levels in this matrix is a marked phenomenon of neuropsychiatric disorders includin
Externí odkaz:
https://doaj.org/article/092fe5d8d0924639bf4e32abb9d6f48b
Autor:
Yoshiaki Kikkawa, Chie Shimamoto-Mitsuyama, Motoko Maekawa, Shabeesh Balan, Tetsuro Ohmori, Hisako Ohba, Akiko Watanabe, Tomomi Shimogori, Tetsuo Ohnishi, Takeo Yoshikawa, Shusuke Numata, Yoshimi Iwayama, Tomoko Toyota, Manabu Toyoshima, Yasuko Hisano, Takeshi Hayashi, Yuki Miyasaka, Tomonori Hara
Publikováno v:
Schizophrenia Bulletin
We previously identified quantitative trait loci (QTL) for prepulse inhibition (PPI), an endophenotype of schizophrenia, on mouse chromosome 10 and reported Fabp7 as a candidate gene from an analysis of F2 mice from inbred strains with high (C57BL/6N