Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer.

Autor: Feng Y; Department of Pharmacology and Therapeutics, University of FloridaCollege of Medicine, Gainesville, FL, USA., Yuan Q; Department of Pharmacology and Therapeutics, University of FloridaCollege of Medicine, Gainesville, FL, USA., Newsome RC; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of FloridaCollege of Medicine, Gainesville, FL, USA., Robinson T; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Bowman RL; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Zuniga AN; Department of Anatomy and Cell Biology, University of FloridaCollege of Medicine, Gainesville, FL, USA., Hall KN; Department of Pharmacology and Therapeutics, University of FloridaCollege of Medicine, Gainesville, FL, USA., Bernsten CM; Department of Pharmacology and Therapeutics, University of FloridaCollege of Medicine, Gainesville, FL, USA., Shabashvili DE; Department of Pharmacology and Therapeutics, University of FloridaCollege of Medicine, Gainesville, FL, USA., Krajcik KI; Department of Pharmacology and Therapeutics, University of FloridaCollege of Medicine, Gainesville, FL, USA., Gunaratne C; Department of Pharmacology and Therapeutics, University of FloridaCollege of Medicine, Gainesville, FL, USA., Zaroogian ZJ; Department of Pharmacology and Therapeutics, University of FloridaCollege of Medicine, Gainesville, FL, USA., Venugopal K; Department of Pharmacology and Therapeutics, University of FloridaCollege of Medicine, Gainesville, FL, USA., Casellas Roman HL; Department of Pharmacology and Therapeutics, University of FloridaCollege of Medicine, Gainesville, FL, USA., Levine RL; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chatila WK; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Yaeger R; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Riva A; Interdisciplinary Center for Biotechnology Research, University of Florida , Gainesville, FL, USA.; University of Florida Health Cancer Center , Gainesville, FL, USA., Jobin C; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of FloridaCollege of Medicine, Gainesville, FL, USA.; University of Florida Health Cancer Center , Gainesville, FL, USA., Kopinke D; Department of Pharmacology and Therapeutics, University of FloridaCollege of Medicine, Gainesville, FL, USA., Avram D; Department of Anatomy and Cell Biology, University of FloridaCollege of Medicine, Gainesville, FL, USA.; University of Florida Health Cancer Center , Gainesville, FL, USA.; Immunology Department, Moffitt Cancer Center, Tampa, FL, USA., Guryanova OA; Department of Pharmacology and Therapeutics, University of FloridaCollege of Medicine, Gainesville, FL, USA.; University of Florida Health Cancer Center , Gainesville, FL, USA.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2023 Nov 06; Vol. 220 (11). Date of Electronic Publication: 2023 Aug 24.

DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks.

Autor: Venugopal K; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida., Feng Y; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida., Nowialis P; Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, Florida., Xu H; Department of Pediatrics, Division of Infectious Diseases, University of Florida College of Medicine, Gainesville, Florida., Shabashvili DE; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida., Berntsen CM; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida., Kaur P; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida., Krajcik KI; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida., Taragjini C; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida., Zaroogian Z; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida., Casellas Román HL; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida., Posada LM; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida., Gunaratne C; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida., Li J; Department of Medicine, Division of Hematology/ Oncology, University of Florida College of Medicine, Gainesville, Florida., Dupéré-Richer D; Department of Medicine, Division of Hematology/ Oncology, University of Florida College of Medicine, Gainesville, Florida., Bennett RL; Department of Medicine, Division of Hematology/ Oncology, University of Florida College of Medicine, Gainesville, Florida.; University of Florida Health Cancer Center, Gainesville, Florida., Pondugula S; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida., Riva A; University of Florida Health Cancer Center, Gainesville, Florida.; Bioinformatics Core, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida., Cogle CR; Department of Medicine, Division of Hematology/ Oncology, University of Florida College of Medicine, Gainesville, Florida.; University of Florida Health Cancer Center, Gainesville, Florida., Opavsky R; Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, Florida.; University of Florida Health Cancer Center, Gainesville, Florida., Law BK; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida.; University of Florida Health Cancer Center, Gainesville, Florida., Bhaduri-McIntosh S; Department of Pediatrics, Division of Infectious Diseases, University of Florida College of Medicine, Gainesville, Florida.; University of Florida Health Cancer Center, Gainesville, Florida.; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida., Kubicek S; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Staber PB; Division of Hematology and Hemostaseology, Department of Medicine 1, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria., Licht JD; Department of Medicine, Division of Hematology/ Oncology, University of Florida College of Medicine, Gainesville, Florida.; University of Florida Health Cancer Center, Gainesville, Florida., Bird JE; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida., Guryanova OA; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida.; University of Florida Health Cancer Center, Gainesville, Florida.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2022 Feb 15; Vol. 28 (4), pp. 756-769.

Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2.

Autor: Naffin-Olivos JL; Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, United States of America., Georgieva M; Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America., Goldfarb N; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, United States of America., Madan-Lala R; Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America., Dong L; Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, United States of America., Bizzell E; Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America., Valinetz E; Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, United States of America., Brandt GS; Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, United States of America; Franklin and Marshall College, Lancaster, Pennsylvania, United States of America., Yu S; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, United States of America., Shabashvili DE; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, United States of America., Ringe D; Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, United States of America., Dunn BM; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, United States of America., Petsko GA; Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, United States of America., Rengarajan J; Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America; Division of Infectious Diseases, Department of Medicine, Emory University, Atlanta, Georgia, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2014 May 15; Vol. 10 (5), pp. e1004132. Date of Electronic Publication: 2014 May 15 (Print Publication: 2014).