Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Shaban, Darwish"'
Autor:
Shirley Tong, Shaban Darwish, Hanieh Hossein Nejad Ariani, Kate Alison Lozada, David Salehi, Maris A. Cinelli, Richard B. Silverman, Kamaljit Kaur, Sun Yang
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1036 (2022)
Melanoma is the most fatal type of skin cancer and is notoriously resistant to chemotherapies. The response of melanoma to current treatments is difficult to predict. To combat these challenges, in this study, we utilize a small peptide to increase d
Externí odkaz:
https://doaj.org/article/f68c3b7cebf0487eaafc545e94009bcd
Autor:
Razan Alhazmi, Shirley Tong, Shaban Darwish, Elina Khanjani, Bharti Khungar, Swati Chawla, Zhonghui Zheng, Richard Chamberlin, Keykavous Parang, Sun Yang
Publikováno v:
Molecules, Vol 27, Iss 9, p 2672 (2022)
Human malignant melanoma exhibits imbalances in redox status, leading to activation of many redox-sensitive signaling pathways. APE/Ref-1 is a multifunctional protein that serves as a redox chaperone that regulates many nuclear transcription factors
Externí odkaz:
https://doaj.org/article/c76c9ca8065d4a208dbda9738a852b89
Publikováno v:
Letters in Organic Chemistry. 16:668-675
The phosphorus atom in hexamethyl phosphorus triamide 5 attacks the carbonyl function in 2-chloroquinoline-3-carbaldehyde 4a to give the bis-quinolinyl ethanone product 6. On the other hand, quinoline ring-attack proceeds by the same phosphorus reage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::967b0a74374667421670467245cbdd95
https://doi.org/10.2174/1570178616666181231161801
https://doi.org/10.2174/1570178616666181231161801
Autor:
Shinichi, Fukuda, Akhil, Varshney, Benjamin J, Fowler, Shao-Bin, Wang, Siddharth, Narendran, Kameshwari, Ambati, Tetsuhiro, Yasuma, Joseph, Magagnoli, Hannah, Leung, Shuichiro, Hirahara, Yosuke, Nagasaka, Reo, Yasuma, Ivana, Apicella, Felipe, Pereira, Ryan D, Makin, Eamonn, Magner, Xinan, Liu, Jian, Sun, Mo, Wang, Kirstie, Baker, Kenneth M, Marion, Xiwen, Huang, Elmira, Baghdasaryan, Meenakshi, Ambati, Vidya L, Ambati, Akshat, Pandey, Lekha, Pandya, Tammy, Cummings, Daipayan, Banerjee, Peirong, Huang, Praveen, Yerramothu, Genrich V, Tolstonog, Ulrike, Held, Jennifer A, Erwin, Apua C M, Paquola, Joseph R, Herdy, Yuichiro, Ogura, Hiroko, Terasaki, Tetsuro, Oshika, Shaban, Darwish, Ramendra K, Singh, Saghar, Mozaffari, Deepak, Bhattarai, Kyung Bo, Kim, James W, Hardin, Charles L, Bennett, David R, Hinton, Timothy E, Hanson, Christian, Röver, Keykavous, Parang, Nagaraj, Kerur, Jinze, Liu, Brian C, Werner, S Scott, Sutton, Srinivas R, Sadda, Gerald G, Schumann, Bradley D, Gelfand, Fred H, Gage, Jayakrishna, Ambati
Publikováno v:
Proc Natl Acad Sci U S A
Alu retroelements propagate via retrotransposition by hijacking long interspersed nuclear element-1 (L1) reverse transcriptase (RT) and endonuclease activities. Reverse transcription of Alu RNA into complementary DNA (cDNA) is presumed to occur exclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62beeef8e70aaaf560f034ebc5905abf
https://pubmed.ncbi.nlm.nih.gov/33526699
https://pubmed.ncbi.nlm.nih.gov/33526699
Autor:
Vidya L. Ambati, Mo Wang, Kyung Bo Kim, Joseph R. Herdy, Siddharth Narendran, Yuichiro Ogura, Bradley D. Gelfand, Eamonn Magner, Jayakrishna Ambati, Apuã C. M. Paquola, Christian Röver, Benjamin J. Fowler, Timothy Hanson, Meenakshi Ambati, Lekha Pandya, Ramendra K. Singh, Yosuke Nagasaka, Kirstie Baker, Jian Sun, James W. Hardin, Jinze Liu, Reo Yasuma, Charles L. Bennett, Genrich V. Tolstonog, Deepak Bhattarai, Praveen Yerramothu, Akshat Pandey, Daipayan Banerjee, Tetsuro Oshika, Gerald G. Schumann, Xinan Liu, Srinivas R. Sadda, Kameshwari Ambati, Tammy H. Cummings, Shaban Darwish, Akhil Varshney, Keykavous Parang, Saghar Mozaffari, Ryan D. Makin, Peirong Huang, Kenneth M. Marion, Elmira Baghdasaryan, Shaobin Wang, Hannah Leung, Brian C. Werner, Jennifer A. Erwin, Nagaraj Kerur, Xiwen Huang, Hiroko Terasaki, Felipe Pereira, S Scott Sutton, Shuichiro Hirahara, David R. Hinton, Ulrike Held, Joseph Magagnoli, Shinichi Fukuda, Ivana Apicella, Fred H. Gage, Tetsuhiro Yasuma
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Significance Alu elements, comprising more than 10% of the human genome, propagate via retrotransposition. This genomic expansion requires enzymatic activity of L1 that reverse transcribes Alu RNA into Alu cDNA in the nucleus. We report Alu also unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faab56470358e690f442ac6be149dcb9
https://doi.org/10.1073/pnas.2022751118
https://doi.org/10.1073/pnas.2022751118
Publikováno v:
International Journal of Peptide Research and Therapeutics. 25:1075-1085
Microbial biofilms are organized communities of cells that are associated with a wide spectrum of resistant and chronic infections that lead to the treatment failure. Accordingly, there is an urgent demand to create novel effective therapeutic drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dd1c094a1a7ffb57ec09ef98b54771d
https://doi.org/10.1007/s10989-018-9755-0
https://doi.org/10.1007/s10989-018-9755-0
Publikováno v:
Tetrahedron Letters. 58:4617-4622
The hydrophobicity of curcumin creates hurdle towards its use in the anticancer therapy. Herein, we synthesized a curcumin-doxorubicin conjugated cyclic peptide scaffold to improve the solubility of curcumin and create a conjugate containing two anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02fd271b2e20d2ad8b0de203964f2982
https://doi.org/10.1016/j.tetlet.2017.10.065
https://doi.org/10.1016/j.tetlet.2017.10.065
Autor:
Rakesh Tiwari, Keykavous Parang, Kiumars Shamloo, Marco Bisoffi, Timothy A. Kristedja, Shaban Darwish, Shang Eun Park
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 13
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3291 (2019)
Volume 20
Issue 13
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3291 (2019)
Prostate cancer (PCa) is the most common malignancy in men and is the leading cause of cancer-related male mortality. A disulfide cyclic peptide ligand [CTVRTSADC] 1 has been previously found to target extra domain B of fibronectin (EDB-FN) in the ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3476ad0be5ac31645563845a83ac2f
https://pubmed.ncbi.nlm.nih.gov/31277465
https://pubmed.ncbi.nlm.nih.gov/31277465
Publikováno v:
Egyptian Journal of Chemistry.
A series of new compounds characterized by presence of quinazoline scaffold and phosphorothioate moiety in their molecular structure, was prepared through reacting Japanese reagent (JR, 1a) and Lawesson reagent (LR, 1b) with quinazoline-4-ones (3a-e)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5b22da24e0d61a9a2f714f47f0cc8fe
https://doi.org/10.21608/ejchem.2019.11548.1736
https://doi.org/10.21608/ejchem.2019.11548.1736
Autor:
Sun Yang, Shirley Fong, Rakesh Tiwari, Neda Sadeghiani, Parinaz Hamidi, Saghar Mozaffari, Shaban Darwish, Thimanthi Withana, Keykavous Parang
Publikováno v:
Eur J Med Chem
Myocardial toxicity and drug resistance caused by drug efflux are major limitations of doxorubicin (Dox)-based chemotherapy. Dox structure modification could be used to develop conjugates with an improved biological profile, such as antiproliferative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacf8108f3a0146f88485ab5c5bde584
https://europepmc.org/articles/PMC8418874/
https://europepmc.org/articles/PMC8418874/
