Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.

Autor: Strom NI; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden., Verhulst B; Psychiatry and Behavioral Sciences, Texas A&M University, College Station, Texas, USA., Bacanu SA; Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA., Cheesman R; PROMENTA Centre, Department of Psychology, University of Oslo, Oslo, Norway., Purves KL; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Gedik H; Institute for Genomics in Health, Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.; Life Sciences, Integrative Life Sciences Doctoral Program, Virginia Commonwealth University, Richmond, Virginia, USA.; Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA., Mitchell BL; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Faculty of Medicine, Queensland University , Brisbane, Queensland, Australia., Kwong AS; Bristol Medical School, Population Health Sciences, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Centre for Clinical Brain Sciences, Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Faucon AB; Division of Medicine, Human Genetics, Vanderbilt University, Nashville, Tennessee, USA., Singh K; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Medland S; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Colodro-Conde L; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Psychology, The University of Queensland, Brisbane, Queensland, Australia., Krebs K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Hoffmann P; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Department of Biomedicine, Human Genomics Research Group, University of Basel; University Hospital Basel, Basel, Switzerland., Herms S; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Institute of Medical Genetics and Pathology, Medical Faculty, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, Human Genomics Research Group, University of Basel; University Hospital Basel, Basel, Switzerland., Gehlen J; Center for Human Genetics, University of Marburg, Marburg, Germany., Ripke S; Dept. of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA., Awasthi S; Dept. of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany., Palviainen T; Helsinki Institute of Life Science, Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Helsinki, Finland., Tasanko EM; Faculty of Medicine, Department of Psychology and Logopedics, SleepWell Research Program, University of Helsinki, Helsinki, Finland., Peterson RE; Institute for Genomics in Health, Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.; Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA., Adkins DE; School of Medicine, Department of Psychiatry, University of Utah, Salt Lake City, Utah, USA., Shabalin AA; School of Medicine, Department of Psychiatry, University of Utah, Salt Lake City, Utah, USA., Adams MJ; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Iveson MH; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Campbell A; College of Medicine and Veterinary Medicine, Institute of Genetics and Cancer; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK., Thomas LF; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; BioCore - Bioinformatics Core Facility, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Winsvold BS; Division of Clinical Neuroscience, Department of Research and Innovation, Oslo University Hospital, Oslo, Norway.; Department of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Neurology, Oslo University Hospital, Oslo, Norway., Drange OK; Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.; Division of Mental Health, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.; NORMENT Centre, University of Oslo, Oslo, Norway.; Centre of Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Psychiatry, Sørlandet Hospital, Kristiansand, Norway., Børte S; Division of Clinical Neuroscience, Department of Research and Innovation; Musculoskeletal Health, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway., Ter Kuile AR; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.; Department of Clinical, Educational and Health Psychology, University College London, London, United Kingdom., Nguyen TH; Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA., Meier SM; Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada., Corfield EC; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; Nic Waals Institute , Lovisenberg Diaconal Hospital, Oslo, Norway., Hannigan L; Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK., Levey DF; Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.; Psychiatry, Research, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA., Czamara D; Department of Genes and Environment, Max-Planck Institute of Psychiatry, Munich, Germany., Weber H; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany., Choi KW; Psychiatry, Center for Precision Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.; Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Pistis G; Psychiatric Epidemiology and Psychopathology Research Center, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly, Switzerland., Couvy-Duchesne B; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; ARAMIS laboratory, Paris Brain Institute, Paris, France.; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Van der Auwera S; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Karlsson R; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Garcia-Argibay M; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Lee D; Department of Statistics, Miami University, Oxford, Ohio, USA., Wang R; Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Bjerkeset O; Faculty of Nursing and Health Science, Nord University, Levanger, Norway.; Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway., Stordal E; Department of Psychiatry, Hospital Namsos, Nord-Trøndelag Health Trustt, Namsos, Norway.; Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway., Bäckmann J; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden., Salum GA; Department of Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.; Child Psychiatry, National Institute of Developmental Psychiatry, São Paulo, Brazil., Zai CC; Tanenbaum Centre for Pharmacogenetics, Molecular Brain Sciences Department, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Division of Neurosciences and Clinical Translation, University of Toronto, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Kennedy JL; Tanenbaum Centre for Pharmacogenetics, Molecular Brain Sciences Department, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Division of Neurosciences and Clinical Translation, University of Toronto, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Zai G; Tanenbaum Centre for Pharmacogenetics, Molecular Brain Sciences Department, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Division of Neurosciences and Clinical Translation, University of Toronto, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Tiwari AK; Tanenbaum Centre for Pharmacogenetics, Molecular Brain Sciences Department, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Division of Neurosciences and Clinical Translation, University of Toronto, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Heilmann-Heimbach S; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Schmidt B; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany., Kaprio J; Helsinki Institute of Life Science, Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Helsinki, Finland., Kennedy MM; Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand., Boden J; Psychological Medicine, University of Otago, Christchurch, New Zealand., Havdahl A; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.; PROMENTA Centre, Department of Psychology, University of Oslo, Oslo, Norway.; Bristol Medical School, Population Health Sciences, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Middeldorp CM; Child Health Research Centre, University of Queensland, Brisbane, Queensland, Australia.; Child and Youth Mental Health Service, Children's Health Queensland Hospital and Health Service, Brisbane, Queensland, Australia., Lopes FL; National Institute of Mental Health, Human Genetics Branch, National Institutes of Health, Bethesda, Maryland, USA.; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, USA., Akula N; National Institute of Mental Health, Genetic Basis of Mood and Anxiety Disorders, National Institutes of Health, Bethesda, Maryland, USA., McMahon FJ; National Institute of Mental Health, Genetic Basis of Mood and Anxiety Disorders, National Institutes of Health, Bethesda, Maryland, USA.; Psychiatry & Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA., Binder EB; Department of Genes and Environment, Max-Planck Institute of Psychiatry, Munich, Germany., Fehm L; Department of Psychology, Zentrum für Psychotherapie, Humboldt-Universität zu Berlin, Berlin, Germany., Ströhle A; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Castelao E; Psychiatric Epidemiology and Psychopathology Research Center, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly, Switzerland., Tiemeier H; Social and Behavioral Science, T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.; Child and Adolescent Psychiatry, Erasmus University Medical Center, Rotterdam, Netherlands., Stein DJ; SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Whiteman D; Population Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Olsen C; Population Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Fuller Z; 23andMe, Sunnyvale, CA, USA., Wang X; 23andMe, Sunnyvale, CA, USA., Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Department of Psychiatry, University of Oxford, Oxford, UK., Byrne EM; Child Health Research Centre, University of Queensland, Brisbane, Queensland, Australia., Lewis G; UCL Division of Psychiatry, University College London, London, UK., Timpson NJ; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.; Bristol Medical School, Population Health Sciences, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Davis LK; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Hickie IB; Brain and Mind Centre, University of Sydney, Sydney, Australia., Gillespie NA; Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA., Milani L; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Schumacher J; Center for Human Genetics, University of Marburg, Marburg, Germany., Woldbye DP; Department of Neuroscience, Laboratory of Neural Plasticity, University of Copenhagen, Copenhagen, Denmark., Forstner AJ; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.; Center for Human Genetics, University of Marburg, Marburg, Germany., Nöthen MM; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Hovatta I; Faculty of Medicine, Department of Psychology and Logopedics and SleepWell Research Program, University of Helsinki, Helsinki, Finland., Horwood J; Psychological Medicine, University of Otago, Christchurch, New Zealand., Copeland WE; UVM Medical Center, Department of Psychiatry, University of Vermont, Burlington, Vermont, USA., Maes HH; Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.; Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA.; Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA., McIntosh AM; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Andreassen OA; NORMENT Centre, University of Oslo, Oslo, Norway.; Centre of Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and University of Oslo, Oslo, Norway.; K. G. Jebsen Center for Neurodevelopmental disorders, University of Oslo, Oslo, Norway., Zwart JA; Division of Clinical Neuroscience, Department of Research and Innovation; Musculoskeletal Health, Oslo University Hospital, Oslo, Norway.; Department of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Mors O; Department of Psychiatry, Psychosis Research Unit, Aarhus University Hospital, Aarhus, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus University, Aarhus, Denmark., Børglum AD; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus University, Aarhus, Denmark.; Center for Genomics and Personalised Medicine, Aarhus University, Aarhus, Denmark., Mortensen PB; The National Centre for Register-based Research, Aarhus University, Aarhus, Denmark., Ask H; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; PROMENTA Centre, Department of Psychology, University of Oslo, Oslo, Norway., Reichborn-Kjennerud T; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; NORMENT Centre, University of Oslo, Oslo, Norway., Najman JM; Faculty of Medicine, School of Public Health, University of Queensland, Herston, Queensland, Australia., Stein MB; Psychiatry, University of California San Diego, La Jolla, CA, USA.; School of Public Health, University of California San Diego, La Jolla, CA, USA., Gelernter J; Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.; Psychiatry Research, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA.; Departments of Genetics and Neuroscience, Yale University of Medicine, New Haven, Connecticut, USA., Milaneschi Y; Amsterdam Neuroscience; Amsterdam Public Health, Amsterdam University Medical Center, Amsterdam, Netherlands., Penninx BW; Amsterdam Neuroscience; Amsterdam Public Health, Amsterdam University Medical Center, Amsterdam, Netherlands., Boomsma DI; Twin Register and Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.; Amsterdam Public Health, Amsterdam University Medical Center, Amsterdam, Netherlands., Maron E; Psychiatry, University of Tartu, Tartu, Estonia.; Department of Medicine, Centre for Neuropsychopharmacology,, Division of Brain Sciences, Imperial College London, London, UK., Erhardt-Lehmann A; Department of Genes and Environment, Max-Planck Institute of Psychiatry, Munich, Germany.; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, Würzburg, Germany., Rück C; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden., Kircher TT; Department of Psychiatry, University of Marburg, Marburg, Germany., Melzig CA; Psychology, Clinical Psychology, Experimental Psychopathology and Psychotherapy, University of Marburg, Marburg, Germany.; Psychology, Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany., Alpers GW; School of Social Sciences, Department of Psychology, University of Mannheim, Mannheim, Germany., Arolt V; Department of Mental Health, Institute for Translational Psychiatry, University of Muenster, Muenster, Germany., Domschke K; Department of Psychiatry and Psychotherapy, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Center for Mental Health (DZPG), Partner Site Berlin, Berlin, Germany., Smoller JW; Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Psychiatry, Center for Precision Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA., Preisig M; Psychiatric Epidemiology and Psychopathology Research Center, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly, Switzerland., Martin NG; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Lupton MK; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Faculty of Medicine, Queensland University , Brisbane, Queensland, Australia.; Faculty of Health, Queensland University of technology, Queensland, Australia., Luik AI; Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands., Reif A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt - Goethe University, Frankfurt, Germany., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Larsson H; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Oldehinkel AJ; Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Hartman CA; Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Breen G; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Docherty AR; School of Medicine, Psychiatry, University of Utah, Salt Lake City, Utah, USA.; School of Medicine, Psychiatry; Huntsman Mental Health Institute, University of Utah, Salt Lake City, Utah, USA.; Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA., Coon H; School of Medicine, Psychiatry, University of Utah, Salt Lake City, Utah, USA., Conrad R; Department of Psychosomatic Medicine and Psychotherapy, University Hospital Münster, Münster, Germany., Lehto K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Deckert J; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, Würzburg, Germany., Eley TC; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Mattheisen M; Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada.; Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada.; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany., Hettema JM; Psychiatry and Behavioral Sciences, Texas A&M University, Bryan, Texas, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Jul 05. Date of Electronic Publication: 2024 Jul 05.

Examining the relationship between genetic risk for depression and youth episodic stress exposure.

Autor: Harrison TJ; Department of Psychology, Stony Brook University, United States of America. Electronic address: thomas.j.harrison@stonybrook.edu., Docherty AR; Department of Psychiatry, University of Utah School of Medicine, United States of America., Finsaas MC; Department of Epidemiology, Columbia University, United States of America., Kotov R; Department of Psychiatry, Stony Brook University, United States of America., Shabalin AA; Department of Psychiatry, University of Utah School of Medicine, United States of America., Waszczuk MA; Department of Psychology, Rosalind Franklin University of Science and Medicine, United States of America., Katz BA; Department of Psychology, Stony Brook University, United States of America., Davila J; Department of Psychology, Stony Brook University, United States of America., Klein DN; Department of Psychology, Stony Brook University, United States of America.

Publikováno v: Journal of affective disorders [J Affect Disord] 2023 Nov 01; Vol. 340, pp. 649-657. Date of Electronic Publication: 2023 Aug 15.

Polygenic risk scores for asthma and allergic disease associate with COVID-19 severity in 9/11 responders.

Autor: Waszczuk MA; Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America., Morozova O; Department of Public Health Sciences, Biological Sciences Division, University of Chicago, Chicago, Illinois, United States of America., Lhuillier E; World Trade Center Health and Wellness Program, Stony Brook University, Stony Brook, New York, United States of America.; Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America., Docherty AR; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Huntsman Mental Health Institute, Salt Lake City, Utah, United States of America., Shabalin AA; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Huntsman Mental Health Institute, Salt Lake City, Utah, United States of America., Yang X; Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America., Carr MA; World Trade Center Health and Wellness Program, Stony Brook University, Stony Brook, New York, United States of America., Clouston SAP; Program in Public Health, Department of Family, Population, and Preventive Medicine, Stony Brook University, Stony Brook, New York, United States of America., Kotov R; Department of Psychiatry, Stony Brook University, Stony Brook, New York, United States of America., Luft BJ; World Trade Center Health and Wellness Program, Stony Brook University, Stony Brook, New York, United States of America.; Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America.

Publikováno v: PloS one [PLoS One] 2023 Mar 09; Vol. 18 (3), pp. e0282271. Date of Electronic Publication: 2023 Mar 09 (Print Publication: 2023).

Genetic Liability, Exposure Severity, and Post-Traumatic Stress Disorder Predict Cognitive Impairment in World Trade Center Responders.

Autor: Mann FD; Program in Public Health and Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA., Clouston SAP; Program in Public Health and Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA., Cuevas A; Center for Anti-Racism, Social Justice, and Public Health Department of Social and Behavioral Sciences, New York University, New York, NY, USA., Waszczuk MA; Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA., Kuan PF; Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA., Carr MA; World Trade Center Program Clinical Center of Excellence, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA., Docherty AR; Department of Psychiatry, University of Utah, Salt Lake City, UT, USA., Shabalin AA; Department of Psychiatry, University of Utah, Salt Lake City, UT, USA., Gandy SE; Departments of Neurology and Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Luft BJ; World Trade Center Program Clinical Center of Excellence, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.; Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.

Publikováno v: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2023; Vol. 92 (2), pp. 701-712.

TwinEQTL: ultrafast and powerful association analysis for eQTL and GWAS in twin studies.

Autor: Xia K; Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA.; Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA., Shabalin AA; Department of Psychiatry, University of Utah, Salt Lake City, UT 84108, USA., Yin Z; Gilead Sciences, Foster City, CA 94404, USA., Chung W; School of Public Health, Harvard, Boston, MA 02115, USA., Sullivan PF; Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA., Wright FA; Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27695, USA., Styner M; Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA., Gilmore JH; Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA., Santelli RC; Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48912, USA., Zou F; Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA.

Publikováno v: Genetics [Genetics] 2022 Jul 30; Vol. 221 (4).