Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer.

Autor: Bojmar L; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA.; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Zambirinis CP; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Division of Surgical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA., Hernandez JM; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Chakraborty J; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Shaashua L; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Kim J; Department of Physiology and Biophysics, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Johnson KE; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Hanna S; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Askan G; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Burman J; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA.; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Ravichandran H; Department of Physiology and Biophysics, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA., Zheng J; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Jolissaint JS; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA.; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Srouji R; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA.; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Song Y; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Choubey A; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kim HS; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Cioffi M; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., van Beek E; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sigel C; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Jessurun J; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Velasco Riestra P; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Blomstrand H; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.; Department of Clinical Pathology, Linköping University, Linköping, Sweden., Jönsson C; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Jönsson A; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Lauritzen P; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Buehring W; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Ararso Y; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Hernandez D; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Vinagolu-Baur JP; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Friedman M; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Glidden C; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Firmenich L; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Lieberman G; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Mejia DL; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Nasar N; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Mutvei AP; Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Stockholm, Sweden., Paul DM; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Bram Y; Division of Gastroenterology & Hepatology, Weill Cornell Medicine, New York, NY, USA., Costa-Silva B; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Basturk O; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Boudreau N; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Zhang H; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Matei IR; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Hoshino A; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Kelsen D; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sagi I; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Scherz A; Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel., Scherz-Shouval R; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Yarden Y; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Oren M; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Egeblad M; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Lewis JS; Radiology and Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical College, New York, NY, USA., Keshari K; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Radiology and Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Grandgenett PM; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA., Hollingsworth MA; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA., Rajasekhar VK; Orthopedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Healey JH; Orthopedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Björnsson B; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Simeone DM; Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA., Tuveson DA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Iacobuzio-Donahue CA; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Bromberg J; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Vincent CT; Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Stockholm, Sweden.; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA., O'Reilly EM; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Weill Cornell Medical College, New York, NY, USA., DeMatteo RP; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Balachandran VP; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Immuno-Oncology Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., D'Angelica MI; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kingham TP; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Allen PJ; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Simpson AL; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Elemento O; Department of Physiology and Biophysics, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA., Sandström P; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Schwartz RE; Division of Gastroenterology & Hepatology, Weill Cornell Medicine, New York, NY, USA.; Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA., Jarnagin WR; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lyden D; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA. dcl2001@med.cornell.edu.; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA. dcl2001@med.cornell.edu.

Publikováno v: Nature medicine [Nat Med] 2024 Aug; Vol. 30 (8), pp. 2170-2180. Date of Electronic Publication: 2024 Jun 28.

Stress impairs the efficacy of immune stimulation by CpG-C: Potential neuroendocrine mediating mechanisms and significance to tumor metastasis and the perioperative period

Autor: Levi, B., Matzner, P., Goldfarb, Y., Sorski, L., Shaashua, L., Melamed, R., Rosenne, E., Page, G.G., Ben-Eliyahu, S.

Publikováno v: In Brain Behavior and Immunity August 2016 56:209-220

In vivo suppression of plasma IL-12 levels by acute and chronic stress paradigms: Potential mediating mechanisms and sex differences

Autor: Shaashua, L., Sominsky, L., Levi, B., Sorski, L., Reznick, M., Page, G.G., Ben-Eliyahu, S.

Publikováno v: In Brain Behavior and Immunity August 2012 26(6):996-1005

BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling.

Autor: Shaashua L; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Ben-Shmuel A; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Pevsner-Fischer M; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Friedman G; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Levi-Galibov O; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Nandakumar S; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Barki D; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Nevo R; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Brown LE; Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, Boston, MA, USA., Zhang W; Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, Boston, MA, USA., Stein Y; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Lior C; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Kim HS; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Yonsei Cancer Center, Division of Medical Oncology, Department of Internal Medicine, Graduate School of Medical Science, Brain Korea 21 Project, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea., Bojmar L; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Jarnagin WR; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lecomte N; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Mayer S; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Stok R; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Bishara H; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Hamodi R; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Levy-Lahad E; The Fuld Family Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Golan T; Oncology Institute, Sheba Medical Center at Tel-Hashomer, Tel Aviv University, Tel Aviv, Israel., Porco JA Jr; Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, Boston, MA, USA., Iacobuzio-Donahue CA; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Schultz N; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Tuveson DA; Cancer Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY, USA., Lyden D; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Kelsen D; Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA., Scherz-Shouval R; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel. ruth.shouval@weizmann.ac.il.

Publikováno v: Nature communications [Nat Commun] 2022 Oct 31; Vol. 13 (1), pp. 6513. Date of Electronic Publication: 2022 Oct 31.

Clusterin mediates hydroquinone-induced cytotoxic responses in HL-60 differentiated cells.

Autor: Li, Peimao¹ (AUTHOR) peimao816@126.com, Gong, Qirui² (AUTHOR), Wang, Dianpeng¹ (AUTHOR), Zhang, Zhimin¹ (AUTHOR), Zhang, Wen¹ (AUTHOR)

Publikováno v: Scientific Reports. 12/5/2024, Vol. 14 Issue 1, p1-14. 14p.