Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery.

Autor: Wang Z; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands., Shaabani S; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands., Gao X; Department of Internal Medicine III, University Hospital Ulm, 89081, Ulm, Germany., Ng YLD; Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Sapozhnikova V; Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Cancer Consortium (DKTK) partner site Berlin and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Max Delbrück Center for Molecular Medicine, Berlin, Germany., Mertins P; Max Delbrück Center for Molecular Medicine, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany., Krönke J; Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. jan.kroenke@charite.de.; German Cancer Consortium (DKTK) partner site Berlin and German Cancer Research Center (DKFZ), Heidelberg, Germany. jan.kroenke@charite.de., Dömling A; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands. alexander.domling@upol.cz.; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry and Czech Advanced Technology and Research Institute, Palackӯ University in Olomouc, Olomouc, Czech Republic. alexander.domling@upol.cz.

Publikováno v: Nature communications [Nat Commun] 2023 Dec 19; Vol. 14 (1), pp. 8437. Date of Electronic Publication: 2023 Dec 19.

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'Chemistry at the speed of sound': automated 1536-well nanoscale synthesis of 16 scaffolds in parallel.

Autor: Gao L; Department of Drug Design, University of Groningen Groningen The Netherlands., Shaabani S; Department of Drug Design, University of Groningen Groningen The Netherlands., Reyes Romero A; Department of Drug Design, University of Groningen Groningen The Netherlands., Xu R; Department of Drug Design, University of Groningen Groningen The Netherlands., Ahmadianmoghaddam M; Department of Drug Design, University of Groningen Groningen The Netherlands., Dömling A; CATRIN, Department of Innovative Chemistry, Palacký University Olomouc Olomouc Czech Republic alexander.domling@upol.cz.

Publikováno v: Green chemistry : an international journal and green chemistry resource : GC [Green Chem] 2023 Jan 17; Vol. 25 (4), pp. 1380-1394. Date of Electronic Publication: 2023 Jan 17 (Print Publication: 2023).

Biphenyl Ether Analogs Containing Pomalidomide as Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction.

Autor: Shaabani S; Department of Drug Design, University of Groningen, 9713 AV Groningen, The Netherlands., Gadina L; Faculty of Chemistry, Jagiellonian University, 30-387 Krakow, Poland., Surmiak E; Faculty of Chemistry, Jagiellonian University, 30-387 Krakow, Poland., Wang Z; Department of Drug Design, University of Groningen, 9713 AV Groningen, The Netherlands., Zhang B; Department of Drug Design, University of Groningen, 9713 AV Groningen, The Netherlands., Butera R; Department of Drug Design, University of Groningen, 9713 AV Groningen, The Netherlands., Zarganes-Tzitzikas T; Department of Drug Design, University of Groningen, 9713 AV Groningen, The Netherlands., Rodriguez I; Faculty of Chemistry, Jagiellonian University, 30-387 Krakow, Poland., Kocik-Krol J; Faculty of Chemistry, Jagiellonian University, 30-387 Krakow, Poland., Magiera-Mularz K; Faculty of Chemistry, Jagiellonian University, 30-387 Krakow, Poland., Skalniak L; Faculty of Chemistry, Jagiellonian University, 30-387 Krakow, Poland., Dömling A; Department of Drug Design, University of Groningen, 9713 AV Groningen, The Netherlands., Holak TA; Faculty of Chemistry, Jagiellonian University, 30-387 Krakow, Poland.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2022 May 27; Vol. 27 (11). Date of Electronic Publication: 2022 May 27.

Combining High-Throughput Synthesis and High-Throughput Protein Crystallography for Accelerated Hit Identification.

Autor: Sutanto F; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands., Shaabani S; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands., Oerlemans R; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands., Eris D; Photon Science Division, Paul Scherrer Institute, Switzerland., Patil P; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands., Hadian M; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands., Wang M; Photon Science Division, Paul Scherrer Institute, Switzerland., Sharpe ME; Photon Science Division, Paul Scherrer Institute, Switzerland., Groves MR; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands., Dömling A; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Aug 09; Vol. 60 (33), pp. 18231-18239. Date of Electronic Publication: 2021 Jul 09.