Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sha-Hua Huang"'
Publikováno v:
Molecules, Vol 27, Iss 13, p 4324 (2022)
Lemonomycin (1) was first isolated from the fermentation broth of Streptomyces candidus in 1964. The complete chemical structure was not elucidated until 2000 with extensive spectroscopic analysis. Lemonomycin is currently known as the only glycosyla
Externí odkaz:
https://doaj.org/article/607d5ccac0a84848a87ca5bfe19b9100
Publikováno v:
Organic Letters. 25:3497-3501
Publikováno v:
Organic Letters. 25:1929-1934
Publikováno v:
SCIENTIA SINICA Chimica. 53:503-515
Publikováno v:
Synthesis. 55:1940-1948
A nine-step synthetic route to access the tricyclic core of FR901483 is reported, featuring a key aza-Wacker cyclization step to construct an α-tertiary amine (ATA) in the bridged structure. The aza-Wacker protocol can tolerate both exocyclic and en
Publikováno v:
Chinese Journal of Chemistry. 39:1022-1024
Publikováno v:
Chemical record (New York, N.Y.). 22(1)
The construction of a structurally rigid architecture with chiral complexity, necessary to enhance the interaction with binding sites of drug targets, has been adapted as an intriguing approach in drug development. In the past few years, we have been
Publikováno v:
Synthesis. 51:2237-2251
FR901483 is a unique alkaloid bearing an aza-tricyclic structure, a phosphate group, and a congested tertiary nitrogen center. This alkaloid was reported to be a potent immunosuppressant with antimetabolite ability. The unprecedented architecture has
Publikováno v:
Tetrahedron. 75:1767-1773
Nitroso-ene (NE) reactions have been adapted in the construction of nitrogen-containing motifs in many biologically interesting compounds. The transient and highly reactive “nitroso” species remains a challenge for designing stereocontrolled synt
Publikováno v:
Tetrahedron. 74:5791-5803
In this full account, the evolution of a synthetic strategy was detailed from a nitroso-ene cyclization to an aza-Wacker reaction for ring construction in the syntheses of melinonine-E and strychnoxanthine. The aza-Wacker cyclization to form the brid