Zobrazeno 1 - 10
of 3 971
pro vyhledávání: '"ShRNA"'
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Background Cell-penetrating peptides (CPPs) are effective for delivering therapeutic molecules with minimal toxicity. This study focuses on the use of penetratin, a well-characterized CPP, to deliver a DNA vector encoding short hairpin RNA (
Externí odkaz:
https://doaj.org/article/903d23d574e54d11bcf8ab6a1ae4c75d
Autor:
Tong-Mei Zhang, Mai-Ning Jiao, Kun Yang, Hua-Lun Wang, Chang-Song Zhang, Shi-Hua Wang, Guan-Meng Zhang, He-Jing Miao, Jun Shen, Ying-Bin Yan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract To explore the role of YAP, a key effector of the Hippo pathway, in temporomandibular joint (TMJ) ankylosis. The temporal and spatial expression of YAP was detected via immunohistochemistry and multiplex immunohistochemistry on postoperative
Externí odkaz:
https://doaj.org/article/22b99e6ecfab4a8091cba4955c7d5fd7
Publikováno v:
eLife, Vol 13 (2024)
Protein kinase A (PKA) plays essential roles in diverse cellular functions. However, the spatiotemporal dynamics of endogenous PKA upon activation remain debated. The classical model predicts that PKA catalytic subunits dissociate from regulatory sub
Externí odkaz:
https://doaj.org/article/7a1ecb86412c48babe8dd9a9434eaacf
Autor:
Wenxi Yu, Sophie F. Hill, Limei Zhu, Yiannos Demetriou, Faith Reger, Joanna Mattis, Miriam H. Meisler
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106591- (2024)
Gain-of-function mutations in SCN8A cause developmental and epileptic encephalopathy (DEE), a disorder characterized by early-onset refractory seizures, deficits in motor and intellectual functions, and increased risk of sudden unexpected death in ep
Externí odkaz:
https://doaj.org/article/189c97fcbc4d4863b31a95564c0f9ff5
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101280- (2024)
Adeno-associated virus (AAV) vectors have become the leading platform for gene delivery in both preclinical research and therapeutic applications, making the production of high-titer AAV preparations essential. To date, most AAV-based studies use con
Externí odkaz:
https://doaj.org/article/f2f2f5ab3b8049c899dee3e3ac4bce71
Autor:
Safiye Nur Yildiz, Maliheh Entezari, Mahshid Deldar Abad Paskeh, Sepideh Mirzaei, Alireza Kalbasi, Amirhossein Zabolian, Farid Hashemi, Kiavash Hushmandi, Mehrdad Hashemi, Mehdi Raei, Mohammad Ali Sheikh Beig Goharrizi, Amir Reza Aref, Ali Zarrabi, Jun Ren, Gorka Orive, Navid Rabiee, Yavuz Nuri Ertas
Publikováno v:
MedComm, Vol 5, Iss 7, Pp n/a-n/a (2024)
Abstract Nonviral vectors, such as liposomes, offer potential for targeted gene delivery in cancer therapy. Liposomes, composed of phospholipid vesicles, have demonstrated efficacy as nanocarriers for genetic tools, addressing the limitations of off
Externí odkaz:
https://doaj.org/article/53a7eda7439548c7a2843c94c4bef5f7
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34075- (2024)
Dysregulation of long noncoding RNAs (lncRNAs), such as maternally expressed gene 3 (MEG3) and long intergenic noncoding RNA regulator of reprogramming (linc-ROR), plays a crucial role in colorectal cancer progression. We aimed to assess linc-ROR sil
Externí odkaz:
https://doaj.org/article/a97f52493d4a441795df78420b3d1cd0
Autor:
Mansi A. Parasrampuria, Adam A. White, Ramadevi Chilamkurthy, Adrian A. Pater, Fatima El-Azzouzi, Katy N. Ovington, Philip J. Jensik, Keith T. Gagnon
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102206- (2024)
Huntington’s disease (HD) is an incurable neurodegenerative disorder caused by genetic expansion of a CAG repeat sequence in one allele of the huntingtin (HTT) gene. Reducing expression of the mutant HTT (mutHTT) protein has remained a clear therap
Externí odkaz:
https://doaj.org/article/17ec7dc92aab4fd2b25cfea55d84c303
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102210- (2024)
Elevated brain angiotensin II activity plays a key role in the development of neurogenic hypertension. While blood pressure (BP) control in neurogenic hypertension has been successfully demonstrated by regulating central angiotensin II activity, curr
Externí odkaz:
https://doaj.org/article/615f208c69c645fc8f101cc58f4bc35b
Autor:
Olanrewaju Oladosu, Emma Chin, Christian Barksdale, Rhonda R. Powell, Terri Bruce, Alexis Stamatikos
Publikováno v:
Pathophysiology, Vol 31, Iss 1, Pp 117-126 (2024)
Atherosclerosis is caused by cholesterol accumulation within arteries. The intima is where atherosclerotic plaque accumulates and where lipid-laden foam cells reside. Intimal foam cells comprise of both monocyte-derived macrophages and macrophage-lik
Externí odkaz:
https://doaj.org/article/ea91ba5490424447ac17aec64b28fa90