A first-in-class Wiskott-Aldrich syndrome protein activator with antitumor activity in hematologic cancers.

Autor: Spriano F; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona., Sartori G; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona., Sgrignani J; Institute of Research in Biomedicine, Faculty of Biomedical Sciences, USI, Bellinzona., Barnabei L; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona., Arribas AJ; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona, Switzerland; SIB Swiss Institute of Bioinformatics, Lausanne., Guala M; Chimete, Tortona., Del Amor AMC; Department of Biomedical and Clinical Sciences, Cell Biology, Medical Faculty, Linköping University, Linköping., Tomasso MR; Drexel University, College of Medicine, Department of Biochemistry and Molecular Biology, Philadelphia, PA., Tarantelli C; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona., Cascione L; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona, Switzerland; SIB Swiss Institute of Bioinformatics, Lausanne., Golino G; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona, Switzerland; Department of Pharmacy, University of Napoli Federico II, Napoli., Riveiro ME; Early Drug Development Group, Boulogne-Billancourt., Bortolozzi R; Department of Woman's and Child's Health, University of Padova, Italy; Istituto di Ricerca Pediatrica IRP, Fondazione Città della Speranza, Padova., Lupia A; Department of Pharmacy, University of Napoli Federico II, Napoli, Italy; Net4science Srl, Magna Graecia University of Catanzaro, Catanzaro., Paduano F; University 'Magna Græcia' of Catanzaro, Catanzaro, Italy; Tecnologica Research Institute and Marrelli Health, Biomedical Section, Stem Cells and Medical Genetics Units, Crotone., Huguet S; Institut Curie, Paris., Rezai K; Institut Curie, Paris., Rinaldi A; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona., Margheriti F; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona., Ventura P; Institute of Research in Biomedicine, Faculty of Biomedical Sciences, USI, Bellinzona., Guarda G; Institute of Research in Biomedicine, Faculty of Biomedical Sciences, USI, Bellinzona., Costa G; University 'Magna Græcia' of Catanzaro, Catanzaro., Rocca R; University 'Magna Græcia' of Catanzaro, Catanzaro., Furlan A; Institute of Research in Biomedicine, Faculty of Biomedical Sciences, USI, Bellinzona., Verdonk LM; Biological Chemistry Group, Institute of Biology Leiden, Leiden University, Leiden., Innocenti P; Biological Chemistry Group, Institute of Biology Leiden, Leiden University, Leiden., Martin NI; Biological Chemistry Group, Institute of Biology Leiden, Leiden University, Leiden., Viola G; Department of Woman's and Child's Health, University of Padova, Italy; Istituto di Ricerca Pediatrica IRP, Fondazione Città della Speranza, Padova., Driessen C; Kantosspital St Gallen, St Gallen., Zucca E; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona, Switzerland; Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona., Stathis A; Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona., Gahtory D; BIMINI Biotech B.V., Leiden., Van den Nieuwboer M; BIMINI Biotech B.V., Leiden., Bornhauser B; Children's Hospital Zurich, Zurich., Alcaro S; University 'Magna Græcia' of Catanzaro, Catanzaro., Trapasso F; University 'Magna Græcia' of Catanzaro, Catanzaro., Cristobal S; Department of Biomedical and Clinical Sciences, Cell Biology, Medical Faculty, Linköping University, Linköping, Sweden; Ikerbasque, Basque Foundation for Sciences, Department of Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country., Padrick SB; Drexel University, College of Medicine, Department of Biochemistry and Molecular Biology, Philadelphia, PA., Pazzi N; Chimete, Tortona., Cavalli F; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona., Cavalli A; Institute of Research in Biomedicine, Faculty of Biomedical Sciences, USI, Bellinzona., Gaudio E; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona. eugaudio1976@gmail.com., Bertoni F; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona, Switzerland; Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona. francesco.bertoni@ior.usi.ch.

Publikováno v: Haematologica [Haematologica] 2024 Nov 01; Vol. 109 (11), pp. 3602-3614. Date of Electronic Publication: 2024 Nov 01.

Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice.

Autor: Zumerle S; Veneto Institute of Molecular Medicine, Padova, Italy.; Department of Medicine, University of Padova, Padova, Italy., Sarill M; Veneto Institute of Molecular Medicine, Padova, Italy.; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy., Saponaro M; Veneto Institute of Molecular Medicine, Padova, Italy.; Department of Medicine, University of Padova, Padova, Italy.; Department of Urology and Pediatric Urology, University Medical Center Bonn (UKB), Bonn, Germany., Colucci M; Institute of Oncology Research (IOR), Bellinzona, Switzerland.; Università della Svizzera italiana, Lugano, Switzerland.; Faculty of Biology and Medicine, University of Lausanne UNIL, Lausanne, Switzerland., Contu L; Veneto Institute of Molecular Medicine, Padova, Italy.; Department of Medicine, University of Padova, Padova, Italy., Lazzarini E; Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Euler Institute, Università della Svizzera Italiana, Lugano, Switzerland., Sartori R; Veneto Institute of Molecular Medicine, Padova, Italy.; Department of Biomedical Sciences, University of Padova, Padova, Italy., Pezzini C; Veneto Institute of Molecular Medicine, Padova, Italy.; Department of Biomedical Sciences, University of Padova, Padova, Italy., Rinaldi A; Department of Medicine, Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland., Scanu A; Department of Neuroscience, Rehabilitation Unit, University of Padova, Padova, Italy., Sgrignani J; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Locatelli P; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Sabbadin M; Veneto Institute of Molecular Medicine, Padova, Italy.; Department of Medicine, University of Padova, Padova, Italy.; Veneto Institute of Oncology IOV - IRCCS, Padova, Italy., Valdata A; Institute of Oncology Research (IOR), Bellinzona, Switzerland.; Università della Svizzera italiana, Lugano, Switzerland.; Department of Health Sciences and Technology (D-HEST), ETH Zurich, Zurich, Switzerland., Brina D; Institute of Oncology Research (IOR), Bellinzona, Switzerland.; Università della Svizzera italiana, Lugano, Switzerland., Giacomini I; Veneto Institute of Molecular Medicine, Padova, Italy.; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy., Rizzo B; Veneto Institute of Molecular Medicine, Padova, Italy.; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.; Veneto Institute of Oncology IOV - IRCCS, Padova, Italy., Pierantoni A; Veneto Institute of Molecular Medicine, Padova, Italy.; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.; Institute for Research on Cancer and Aging, Nice, France., Sharifi S; Veneto Institute of Molecular Medicine, Padova, Italy.; Department of Medicine, University of Padova, Padova, Italy.; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy., Bressan S; Veneto Institute of Molecular Medicine, Padova, Italy.; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.; Institute of Oncology Research (IOR), Bellinzona, Switzerland.; Università della Svizzera italiana, Lugano, Switzerland., Altomare C; Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Euler Institute, Università della Svizzera Italiana, Lugano, Switzerland., Goshovska Y; Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Euler Institute, Università della Svizzera Italiana, Lugano, Switzerland., Giraudo C; Department of Medicine, University of Padova, Padova, Italy.; Department of Cardiac, Thoracic, Vascular Sciences and Public Health - DCTV, University of Padova, Padova, Italy., Luisetto R; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy., Iaccarino L; Department of Medicine, University of Padova, Padova, Italy., Torcasio C; Department of Medicine, Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland., Mosole S; Institute of Oncology Research (IOR), Bellinzona, Switzerland.; Università della Svizzera italiana, Lugano, Switzerland., Pasquini E; Institute of Oncology Research (IOR), Bellinzona, Switzerland.; Università della Svizzera italiana, Lugano, Switzerland., Rinaldi A; Institute of Oncology Research (IOR), Bellinzona, Switzerland.; Università della Svizzera italiana, Lugano, Switzerland., Pellegrini L; Institute of Oncology Research (IOR), Bellinzona, Switzerland.; Università della Svizzera italiana, Lugano, Switzerland., Peron G; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Fassan M; Department of Medicine, University of Padova, Padova, Italy.; Veneto Institute of Oncology IOV - IRCCS, Padova, Italy., Masiero S; Department of Neuroscience, Rehabilitation Unit, University of Padova, Padova, Italy., Giori AM; R&D Department, IBSA Farmaceutici Italia, Lodi, Italy., Dall'Acqua S; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy., Auwerx J; Laboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Cippà P; Università della Svizzera italiana, Lugano, Switzerland.; Department of Medicine, Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland., Cavalli A; Università della Svizzera italiana, Lugano, Switzerland.; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Bolis M; Institute of Oncology Research (IOR), Bellinzona, Switzerland.; Università della Svizzera italiana, Lugano, Switzerland., Sandri M; Veneto Institute of Molecular Medicine, Padova, Italy.; Department of Biomedical Sciences, University of Padova, Padova, Italy., Barile L; Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Euler Institute, Università della Svizzera Italiana, Lugano, Switzerland., Montopoli M; Veneto Institute of Molecular Medicine, Padova, Italy. monica.montopoli@unipd.it.; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy. monica.montopoli@unipd.it., Alimonti A; Veneto Institute of Molecular Medicine, Padova, Italy. andrea.alimonti@ior.usi.ch.; Department of Medicine, University of Padova, Padova, Italy. andrea.alimonti@ior.usi.ch.; Institute of Oncology Research (IOR), Bellinzona, Switzerland. andrea.alimonti@ior.usi.ch.; Università della Svizzera italiana, Lugano, Switzerland. andrea.alimonti@ior.usi.ch.; Department of Health Sciences and Technology (D-HEST), ETH Zurich, Zurich, Switzerland. andrea.alimonti@ior.usi.ch.; Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland. andrea.alimonti@ior.usi.ch.

Publikováno v: Nature aging [Nat Aging] 2024 Sep; Vol. 4 (9), pp. 1231-1248. Date of Electronic Publication: 2024 Jul 01.

Computational Design of Novel Cyclic Peptides Endowed with Autophagy-Inhibiting Activity on Cancer Cell Lines.

Autor: Albani M; Department of Pharmaceutical Sciences, Università degli Studi di Milano, Via L. Mangiagalli 25, 20133 Milano, Italy., Fassi EMA; Department of Pharmaceutical Sciences, Università degli Studi di Milano, Via L. Mangiagalli 25, 20133 Milano, Italy., Moretti RM; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy., Garofalo M; Department of Pharmaceutical and Pharmacological Sciences, Università di Padova, Via F. Marzolo 5, 35131 Padova, Italy., Montagnani Marelli M; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy., Roda G; Department of Pharmaceutical Sciences, Università degli Studi di Milano, Via L. Mangiagalli 25, 20133 Milano, Italy., Sgrignani J; Institute for Research in Biomedicine (IRB), Via Chiesa 5, 6500 Bellinzona, Switzerland., Cavalli A; Institute for Research in Biomedicine (IRB), Via Chiesa 5, 6500 Bellinzona, Switzerland.; Swiss Institute of Bioinformatics (SIB), University of Lausanne, Quartier UNIL-Sorge, Bâtiment Amphipôle, 1015 Lausanne, Switzerland., Grazioso G; Department of Pharmaceutical Sciences, Università degli Studi di Milano, Via L. Mangiagalli 25, 20133 Milano, Italy.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 24; Vol. 25 (9). Date of Electronic Publication: 2024 Apr 24.

Esmethadone-HCl (REL-1017): a promising rapid antidepressant.

Autor: Fava M; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, 02114, USA., Stahl SM; Department of Psychiatry, VAMC (SD), University of California, San Diego, La Jolla, CA, 92093, USA.; Neuroscience Education Institute, Carlsbad, CA, 92008, USA., De Martin S; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, 35122, Padua, Italy., Mattarei A; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, 35122, Padua, Italy., Bettini E; In Vitro Pharmacology Department, Aptuit, an Evotec Company, 37135, Verona, Italy., Comai S; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, 35122, Padua, Italy.; Department of Biomedical Sciences, University of Padua, 35122, Padua, Italy.; Department of Psychiatry, McGill University, Montreal, QC, H3A 1A1, Canada., Alimonti A; Department of Health Sciences and Technology, ETH Zurich, 8092, Zurich, Switzerland.; Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), 6500, Bellinzona, Switzerland.; Università della Svizzera Italiana, 6900, Lugano, Switzerland.; Veneto Institute of Molecular Medicine, 35129, Padua, Italy.; Department of Medicine-DIMED, University of Padua, 35122, Padua, Italy., Bifari F; Department of Medical Biotechnology and Translational Medicine, University of Milan, 20122, Milan, Italy., Pani L; Relmada Therapeutics, Coral Gables, FL, 33134, USA.; Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Miami, Miami, FL, 33146, USA.; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41121, Modena, Italy., Folli F; Department of Health Sciences, University of Milan, 20122, Milan, Italy., Guidetti C; Child and Adolescent Neuropsychiatry Unit, Department of Neuroscience, Bambino Gesù Pediatric Hospital, 00165, Rome, Italy., Furlan A; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, 35122, Padua, Italy., Sgrignani J; Institute for Research in Biomedicine (IRB), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland., Locatelli P; Institute for Research in Biomedicine (IRB), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland., Cavalli A; Institute for Research in Biomedicine (IRB), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland.; Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland., O'Gorman C; Relmada Therapeutics, Coral Gables, FL, 33134, USA., Traversa S; Relmada Therapeutics, Coral Gables, FL, 33134, USA., Inturrisi CE; Relmada Therapeutics, Coral Gables, FL, 33134, USA., Pappagallo M; Relmada Therapeutics, Coral Gables, FL, 33134, USA., Manfredi PL; Relmada Therapeutics, Coral Gables, FL, 33134, USA. pmanfredi@relmada.com.

Publikováno v: European archives of psychiatry and clinical neuroscience [Eur Arch Psychiatry Clin Neurosci] 2023 Oct; Vol. 273 (7), pp. 1463-1476. Date of Electronic Publication: 2023 Mar 08.

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