Zobrazeno 1 - 10
of 1 226
pro vyhledávání: '"Sgourakis"'
Autor:
Woodward, Claire H. 1, 2, Solieva, Shahlo O. 1, 3, Hwang, Daniel 1, 2, De Paula, Viviane S. 1, 2, Fabilane, Charina S. 4, 5, Young, Michael C. 1, 2, Trent, Tony 1, 3, Teeley, Ella C. 6, Majumdar, Ananya 7, Spangler, Jamie B. 4, 6, 8, Bowman, Gregory R. 1, 3, Sgourakis, Nikolaos G. 1, 2, ⁎
Publikováno v:
In Journal of Molecular Biology 15 January 2025 437(2)
Autor:
Andrew C. McShan, David Flores-Solis, Yi Sun, Samuel E. Garfinkle, Jugmohit S. Toor, Michael C. Young, Nikolaos G. Sgourakis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The conformational landscapes of peptide/human leucocyte antigen (pHLA) protein complexes encompassing tumor neoantigens provide a rationale for target selection towards autologous T cell, vaccine, and antibody-based therapeutic modalities.
Externí odkaz:
https://doaj.org/article/3d091fa11d8640f789c98250daa34e87
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The class I proteins of the major histocompatibility complex (MHC-I) display epitopic peptides derived from endogenous proteins on the cell surface for immune surveillance. Accurate modeling of peptides bound to the human MHC, HLA, has been
Externí odkaz:
https://doaj.org/article/e05b9ea7d65d4b9e8b5486e25b3a7ba8
Akademický článek
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Autor:
Sgourakis George, Gockel Ines, Karaliotas Constantine, Moehler Markus, Schimanski Carl, Schmidberger Heinz, Junginger Theodor
Publikováno v:
BMC Cancer, Vol 12, Iss 1, p 70 (2012)
Abstract Background Our aim was to compare survival of the various treatment modality groups of chemotherapy and/or radiotherapy in relation to SEMS (self-expanding metal stents) in a retrospective case-control study. We have made the hypothesis that
Externí odkaz:
https://doaj.org/article/d958130d541e4ce99d2b25c5bddf51b8
Publikováno v:
BMC Bioinformatics, Vol 6, Iss 1, p 104 (2005)
Abstract Background G- Protein coupled receptors (GPCRs) comprise the largest group of eukaryotic cell surface receptors with great pharmacological interest. A broad range of native ligands interact and activate GPCRs, leading to signal transduction
Externí odkaz:
https://doaj.org/article/ccb6aa93af6d4c0ab9662c7e73ceb4bd
Autor:
Papadaki, Georgia F., Woodward, Claire H., Young, Michael C., Winters, Trenton J., Burslem, George M., Sgourakis, Nikolaos G.
Publikováno v:
In Journal of Biological Chemistry October 2023 299(10)
Autor:
J. P. Marrero-Rivera, Olivia Sobkowiak, Aimee Sgourakis Jenkins, Stefano J. Bagnato, Christopher E. Kline, Benjamin DH Gordon, Sharon E. Taverno Ross
Publikováno v:
Children, Vol 11, Iss 3, p 363 (2024)
This scoping review provides an overview of the relationship between physical activity, physical fitness, cognition, and academic outcomes in Latino school-aged children and identifies areas for future research. A primary search was conducted in PubM
Externí odkaz:
https://doaj.org/article/dfce3571ba1d4d8abe03b079a214ff1d
Autor:
Jiansheng Jiang, Daniel K. Taylor, Ellen J. Kim, Lisa F. Boyd, Javeed Ahmad, Michael G. Mage, Hau V. Truong, Claire H. Woodward, Nikolaos G. Sgourakis, Peter Cresswell, David H. Margulies, Kannan Natarajan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The catalytic chaperone tapasin assists peptide loading onto MHC-I molecules for antigen presentation and immune recognition. Here, the authors present crystal structures that provide insights into the molecular mechanism of tapasin-mediated peptide
Externí odkaz:
https://doaj.org/article/c0903e0c423a49729d8d0a758d83bc5c
Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules
Autor:
Georgia F. Papadaki, Omar Ani, Tyler J. Florio, Michael C. Young, Julia N. Danon, Yi Sun, Devin Dersh, Nikolaos G. Sgourakis
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Major Histocompatibility Complex class I (MHC-I) molecules display self, viral or aberrant epitopic peptides to T cell receptors (TCRs), which employ interactions between complementarity-determining regions with both peptide and MHC-I heavy chain ‘
Externí odkaz:
https://doaj.org/article/302e579d551846d78a6301c84be31c34