Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sezgin Kiren"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 734 (2024)
Fluoropyrimidine (FP) drugs are central components of combination chemotherapy regimens for the treatment of colorectal cancer (CRC). FP-based chemotherapy has improved survival outcomes over the last several decades with much of the therapeutic bene
Externí odkaz:
https://doaj.org/article/2ce954d0ef6a4901bb86567a037194cc
Autor:
Komaraiah Palle, Ralph B. D'Agostino, Jonathan R. Brody, Lais P. Ghiraldeli, David L. Caudell, Thomas L. Smith, Sezgin Kiren, Alex Haber, William H. Gmeiner, Anthony Dominijanni, Chinnadurai Mani, Boris Pasche, Zhiyong Deng
Publikováno v:
Mol Cancer Ther
Chemotherapy regimens that include 5-fluorouracil (5-FU) are central to colorectal cancer treatment; however, risk/benefit concerns limit 5-FU’s use, necessitating development of improved fluoropyrimidine (FP) drugs. In our study, we evaluated a se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215d5e5de577f9ecc46170ef41c37f3b
https://doi.org/10.1158/1535-7163.mct-20-0516
https://doi.org/10.1158/1535-7163.mct-20-0516
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbb1ac064e8dadb8f4b0568e7ed558b
https://doi.org/10.2139/ssrn.4047660
https://doi.org/10.2139/ssrn.4047660
Publikováno v:
Tetrahedron Letters. 60:1490-1492
We investigated the reactions of substituted N-acyl-2,3-dihydro-4-pyridones with TosMIC reagent under various basic conditions to generate novel pyrrole products. These products were then transformed to substituted azaisoindoles in a couple of steps.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e5f9ec14ce628ef1bb11c08847dcb00
https://doi.org/10.1016/j.tetlet.2019.04.055
https://doi.org/10.1016/j.tetlet.2019.04.055
Publikováno v:
Tetrahedron. 78:131807
We describe herein a novel, efficient and practical synthetic approach to access pyrrolo[3,4-b]pyridines from dihydropyridones in three steps, in which a pyrrole unit is generated from a dihydropyridone using TosMIC reagent. Protection of the resulti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1caa1820a51966f78a3adc38073de9d0
https://doi.org/10.1016/j.tet.2020.131807
https://doi.org/10.1016/j.tet.2020.131807
Autor:
Sezgin Kiren, Mustafa Guzel
Publikováno v:
Turkiye Klinikleri Journal of Pharmacy Sciences. 5:36-45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc040a5754a33de005874aa2cfd8edf7
https://doi.org/10.5336/pharmsci.2015-48211
https://doi.org/10.5336/pharmsci.2015-48211
Publikováno v:
Tetrahedron Letters. 56:5275-5277
We describe herein a general and efficient synthetic approach toward substituted pyridines from functionalized N -acyl-2,3-dihydropyridones in two steps; 1,2-addition with organocerium reagents and subsequent oxidative aromatization with chloranil. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c86d8449b0eae8da053c70118578bba
https://doi.org/10.1016/j.tetlet.2015.07.045
https://doi.org/10.1016/j.tetlet.2015.07.045
Publikováno v:
ChemInform. 47
We describe herein a general and efficient synthetic approach toward substituted pyridines from functionalized N -acyl-2,3-dihydropyridones in two steps; 1,2-addition with organocerium reagents and subsequent oxidative aromatization with chloranil. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::993bea0ef937a49f9fd5ba48b91b8828
https://doi.org/10.1002/chin.201602136
https://doi.org/10.1002/chin.201602136
Autor:
Albert Padwa, Sezgin Kiren
Publikováno v:
The Journal of Organic Chemistry. 74:7781-7789
A practical benzannulation method to prepare variously substituted aryl amines and sulfides was developed. The approach involves a Michael-aldol reaction of beta-keto sulfones with enones followed by a subsequent condensation of the initial adduct wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e90d1b77551138e874efd7bc66cfb37
https://doi.org/10.1021/jo9017793
https://doi.org/10.1021/jo9017793
Publikováno v:
Tetrahedron. 65:6720-6729
An efficient approach to 2,4-disubstituted pyrroles has been uncovered and is based on an oxidative rearrangement of a furanyl carbamate followed by sequential reaction of the resulting 5-methoxypyrrol-2(5H)-one with various alkyl lithiates. The fina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::339c9665d240900b86d80cf8f0873774
https://doi.org/10.1016/j.tet.2009.03.011
https://doi.org/10.1016/j.tet.2009.03.011