Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sez-Jade Chen"'
Publikováno v:
Photonics, Vol 2, Iss 4, Pp 1027-1042 (2015)
Förster Resonance Energy Transfer (FRET) enables the observation of interactions at the nanoscale level through the use of fluorescence optical imaging techniques. In FRET, fluorescence lifetime imaging can be used to quantify the fluorescence lifet
Externí odkaz:
https://doaj.org/article/132af7d48d7f4283b629bc40cdb449ab
Autor:
Alena Rudkouskaya, Marien Ochoa, Xavier Intes, Joseph E. Mazurkiewicz, Nattawut Sinsuebphon, Margarida Barroso, Sez-Jade Chen
Publikováno v:
Theranostics
Rationale: Following an ever-increased focus on personalized medicine, there is a continuing need to develop preclinical molecular imaging modalities to guide the development and optimization of targeted therapies. Near-Infrared (NIR) Macroscopic Flu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc04efc5e8d6bdeb5fb1df2e2c4db5d
http://europepmc.org/articles/PMC7481426
http://europepmc.org/articles/PMC7481426
Autor:
Xavier Intes, Nattawut Sinsuebphon, Alena Rudkouskaya, Marien Ochoa Mendoza, Joseph E. Mazurkiewicz, Margarida Barroso, Sez-Jade Chen
Publikováno v:
Multiphoton Microscopy in the Biomedical Sciences XIX.
Fluorescence lifetime imaging (FLI) is widely regarded as the most robust means to utilize Forster resonance energy transfer (FRET) to study protein-protein interactions. Upon donor excitation, FLI estimates FRET occurrence by determining the reducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::969b671109a2c233cce444ed540d5736
https://doi.org/10.1117/12.2508056
https://doi.org/10.1117/12.2508056
Autor:
Xavier Intes, Pingkun Yan, Jason T. Smith, Nattawut Sinsuebphon, Margarida Barroso, Alena Rudkouskaya, Sez-Jade Chen, Ruoyang Yao
Publikováno v:
Multimodal Biomedical Imaging XIV.
Fluorescence lifetime imaging (FLI) has become an invaluable tool in the biomedical field by providing unique, quantitative information about biochemical events and interactions taking place within specimens of interest. Applications of FLI range fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86dd36068ad8b2d131b909e0609f2c9e
https://doi.org/10.1117/12.2509857
https://doi.org/10.1117/12.2509857
Autor:
Xavier Michalet, Nattawut Sinsuebphon, Xavier Intes, Sez-Jade Chen, Margarida Barroso, Alena Rudkouskaya
Publikováno v:
Journal of biophotonics. 12(3)
We introduce a simple new approach for time-resolved multiplexed analysis of complex systems using near-infrared (NIR) dyes, applicable to in vitro and in vivo studies. We show that fast and precise in vitro quantification of NIR fluorophores' short
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa8212ea22be22cce1627be71591b21
https://pubmed.ncbi.nlm.nih.gov/30421551
https://pubmed.ncbi.nlm.nih.gov/30421551
Autor:
Joseph E. Mazurkiewicz, Alena Rudkouskaya, Margarida Barroso, Nattawut Sinsuebphon, Xavier Intes, Jamie Ward, Sez-Jade Chen
Publikováno v:
Multiphoton Microscopy in the Biomedical Sciences XVIII.
Monitoring the binding of protein ligands and therapeutic antibodies to their respective receptors (target engagement) is crucial to compound prioritization in anti-cancer targeted drug screening. However, current in vivo optical imaging techniques c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76104a7a95e01e1163a671fa077234ff
https://doi.org/10.1117/12.2297567
https://doi.org/10.1117/12.2297567
Autor:
Nattawut Sinsuebphon, Margarida Barroso, Xavier Intes, Alena Rudkouskaya, Xavier Michalet, Sez-Jade Chen
Publikováno v:
Multimodal Biomedical Imaging XIII.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::520239cd23360e589d0f4b3d66d8eca4
https://doi.org/10.1117/12.2289084
https://doi.org/10.1117/12.2289084
Autor:
Xavier Intes, Alena Rudkouskaya, Xavier Michalet, Nattawut Sinsuebphon, Sez-Jade Chen, Margarida Barroso
1AbstractWe introduce a simple new approach for time-resolved multiplexed analysis of complex systems using near-infrared (NIR) dyes, applicable to in vitro and in vivo studies. We first show that fast and precise in vitro quantification of NIR fluor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce85ff8cd2d2ce3ced6a47e3e635bd9
Publikováno v:
Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS).
Lifetime-based FRET was used to compare the intracellular delivery of PEGylated and non-PEGylated probes in vitro and in vivo for applications in transferrin-based drug delivery.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ce2aad7862fd9ee523d10c5ebf02ad5
https://doi.org/10.1364/translational.2018.jth3a.19
https://doi.org/10.1364/translational.2018.jth3a.19
Publikováno v:
Opt Mol Probes Imaging Drug Deliv
A fast time-gated phasor analysis tool was developed and used to monitor kinetics of NIR FLIM-FRET in vitro and in vivo. The results were validated by comparison with standard two-component fluorescence decay fitting analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a14d0cde921f8f560d0aa25faf9e57e
https://doi.org/10.1364/omp.2017.omtu2d.2
https://doi.org/10.1364/omp.2017.omtu2d.2