Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Seymour de Picciotto"'
Autor:
Seymour de Picciotto, Nicholas DeVita, Chiaowen Joyce Hsiao, Christopher Honan, Sze-Wah Tse, Mychael Nguyen, Joseph D. Ferrari, Wei Zheng, Brian T. Wipke, Eric Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
IL-2 has been used to expand regulatory T (Treg) cells for treating inflammatory disorders. Here the authors test an engineered IL-2 mutein, delivered subcutaneously as mRNA, to show its increased specificity for activating and expanding Treg cells i
Externí odkaz:
https://doaj.org/article/970f3a986644427281a56650bf34012f
Autor:
Seymour de Picciotto, Nicholas DeVita, Chiaowen Joyce Hsiao, Christopher Honan, Sze-Wah Tse, Mychael Nguyen, Joseph D. Ferrari, Wei Zheng, Brian T. Wipke, Eric Huang
Publikováno v:
Nature communications. 13(1)
Interleukin-2 (IL-2) is critical for regulatory T cell (Treg) function and homeostasis. At low doses, IL-2 can suppress immune pathologies by expanding Tregs that constitutively express the high affinity IL-2Rα subunit. However, even low dose IL-2,
Autor:
Yaman Lu, Krista L. Namminga, Howard E. Gendelman, Brian T. Wipke, Katherine E. Olson, Eric Huang, Clayton Small, Sze-Wah Tse, Jared Iacovelli, William Walker, Seymour De Picciotto, R. Lee Mosley, Mackenzie J. Thurston, Aaron D. Schwab
Publikováno v:
Biomaterials
Restoring numbers and function of regulatory T cells (Tregs) is a novel therapeutic strategy for neurodegenerative disorders. Whether Treg function is boosted by adoptive cell transfer, pharmaceuticals, or immune modulators, the final result is a rob
Autor:
K. Dane Wittrup, Bryan S. Marques, Barbara Imperiali, Elke Socher, Seymour de Picciotto, Linda G. Griffith, Michael W. Traxlmayr, A. Joshua Wand, Jonathan D. Kiefer, Paige Dickson, Sixing Zhao, Stephanie Cheung
Publikováno v:
PMC
Quantifying protein location and concentration is critical for understanding function in situ. Scaffold conjugated to environment-sensitive fluorophore (SuCESsFul) biosensors, in which a reporting fluorophore is conjugated to a binding scaffold, can,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d056da95654792e4a85cb76c128b5f2
https://orcid.org/0000-0002-2108-582X
https://orcid.org/0000-0002-2108-582X
Autor:
Alexander Batyuk, Renato Zenobi, Yufan Wu, Basri Gülbakan, Lutz Kummer, Christoph Klenk, K. Dane Wittrup, Peer R. E. Mittl, Seymour de Picciotto, Erik Sedlák, Andreas Plückthun, Franziska Zosel, Jendrik Schöppe, Marco Schütz, Gregory A. Newby
Publikováno v:
Journal of Molecular Biology
Fluorescent probes constitute a valuable toolbox to address a variety of biological questions and they have become irreplaceable for imaging methods. Commonly, such probes consist of fluorescent proteins or small organic fluorophores coupled to biolo
Autor:
Carolyn L. Treasure, Luis M. Alvarez, Richard T. Lee, Yadir Guerrero, Jessica F. Hawkins, Seymour de Picciotto, Edgar Sanchez, Elma Kurtagic, Steven M. Jay, Linda G. Griffith, Robin N. Prince
Publikováno v:
The Journal of Biological Chemistry
PMC
PMC
The ErbB receptor family is dysregulated in many cancers, and its therapeutic manipulation by targeted antibodies and kinase inhibitors has resulted in effective chemotherapies. However, many malignancies remain refractory to current interventions. W
Autor:
Alessandro, Angelini, Tiffany F, Chen, Seymour, de Picciotto, Nicole J, Yang, Alice, Tzeng, Michael S, Santos, James A, Van Deventer, Michael W, Traxlmayr, K Dane, Wittrup
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1319
Yeast surface display is a powerful technology for engineering a broad range of protein scaffolds. This protocol describes the process for de novo isolation of protein binders from large combinatorial libraries displayed on yeast by using magnetic be
Autor:
Nicole J. Yang, Seymour de Picciotto, Alessandro Angelini, K. Dane Wittrup, Michael W. Traxlmayr, James A. Van Deventer, Michael S. Santos, Alice Tzeng, Tiffany F. Chen
Publikováno v:
Methods in Molecular Biology ISBN: 9781493927470
Yeast surface display is a powerful technology for engineering a broad range of protein scaffolds. This protocol describes the process for de novo isolation of protein binders from large combinatorial libraries displayed on yeast by using magnetic be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0348fd15d51dacbe9b9b0dcb2d280a99
https://doi.org/10.1007/978-1-4939-2748-7_1
https://doi.org/10.1007/978-1-4939-2748-7_1
Publikováno v:
PMC
Reagentless biosensors rely on the interaction of a binding partner and its target to generate a change in fluorescent signal using an environment-sensitive fluorophore or Förster resonance energy transfer. Binding affinity can exert a significant i
Publikováno v:
Methods in enzymology. 523
Yeast surface display (YSD) presents proteins on the surface of yeast through interaction of the agglutinin subunits Aga1p and Aga2p. The human 10th type III fibronectin (Fn3) is a small, 10-kDa protein domain that maintains its native fold without d