Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Seymour Benzer"'
Publikováno v:
BioTechniques, Vol 46, Iss 4, Pp 312-314 (2009)
In Drosophila, genetic techniques relying on stochastic chromosomal rearrangements involve the generation and screening of a large number of fly stocks to isolate a few lines of interest. Here, we describe a PCR-based method allowing non-lethal molec
Externí odkaz:
https://doaj.org/article/0101ae8126c54f8fbdca87996cd6267a
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50644 (2012)
Defects in mitochondrial electron transport chain (ETC) function have been implicated in a number of neurodegenerative disorders, cancer, and aging. Mitochondrial complex I (NADH dehydrogenase) is the largest and most complicated enzyme of the ETC wi
Externí odkaz:
https://doaj.org/article/768081d1f76244619d58fdbe3ff485d6
Autor:
Julie Hull-Thompson, Julien Muffat, Diego Sanchez, David W Walker, Seymour Benzer, Maria D Ganfornina, Heinrich Jasper
Publikováno v:
PLoS Genetics, Vol 5, Iss 4, p e1000460 (2009)
Metabolic homeostasis in metazoans is regulated by endocrine control of insulin/IGF signaling (IIS) activity. Stress and inflammatory signaling pathways--such as Jun-N-terminal Kinase (JNK) signaling--repress IIS, curtailing anabolic processes to pro
Externí odkaz:
https://doaj.org/article/aba8379881ef4eca81c455c36c714084
Publikováno v:
Proceedings of the National Academy of Sciences. 106:18633-18637
Dietary restriction (DR) is a widely conserved intervention leading to lifespan extension. Despite considerable effort, the mechanisms underlying DR remain poorly understood. In particular, it remains unclear whether DR prolongs life through conserve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e88aed92514d9f21c3ee7e7a87b5f6
https://doi.org/10.1073/pnas.0908016106
https://doi.org/10.1073/pnas.0908016106
Autor:
Aric N. Rogers, Pankaj Kapahi, Misha A. Vargas, Subhash D. Katewa, Tony Au Lu, Brian M. Zid, Seymour Benzer, Marysia Kolipinski
Publikováno v:
Cell. 139:149-160
SummaryDietary restriction (DR) extends lifespan in multiple species. To examine the mechanisms of lifespan extension upon DR, we assayed genome-wide translational changes in Drosophila. A number of nuclear encoded mitochondrial genes, including thos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2dbf68d22627f6aaa2bf81218e6803
https://doi.org/10.1016/j.cell.2009.07.034
https://doi.org/10.1016/j.cell.2009.07.034
Publikováno v:
Protein Science. 18:2203-2208
Methuselah (Mth) is a G protein-coupled receptor (GPCR) associated with longevity in Drosophila melanogaster. Previously, Stunted (Sun) was identified as a peptide agonist of Mth. Here, we identify two additional activators of Mth signaling: Drosophi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10979013b7a3e4eae1c9e7f4ab7f6214
https://doi.org/10.1002/pro.221
https://doi.org/10.1002/pro.221
Publikováno v:
Neuron. 63(3):329-341
SummaryIn mammals, fat store levels are communicated by leptin and insulin signaling to brain centers that regulate food intake and metabolism. By using transgenic manipulation of neural activity, we report the isolation of two distinct neuronal popu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7bc0e20b5465c50c4917587d0d3f9f
Publikováno v:
Proceedings of the National Academy of Sciences. 105:7088-7093
Apolipoprotein D (ApoD) expression increases in several neurological disorders and in spinal cord injury. We provide a report of a physiological role for human ApoD (hApoD): Flies overexpressing hApoD are long-lived and protected against stress condi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813c0e1be4ac7aaff0f81879ed5d95a6
https://doi.org/10.1073/pnas.0800896105
https://doi.org/10.1073/pnas.0800896105
Publikováno v:
Current Biology. 16(10):1034-1040
Summary A number of repellent compounds produced by plants elicit a spicy or pungent sensation in mammals [1–16]. In several cases, this has been found to occur through activation of ion channels in the transient receptor potential (TRP) family [1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a759fb0be6249905da4d1ca7e7a02056
Publikováno v:
Current Biology. 16(7):692-696
Mating elicits a dramatic reprogramming of female behavior in numerous insect species. In Drosophila, this postmating response (PMR) comprises increased egg-laying rate and reduced sexual receptivity and is controlled by the products of the male acce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf4c6d82705a3af8d81adc85c87c74b