Effects of substrate deprivation therapy on brain lipids in neonatal GML storage disease mice

Autor: Kasperzyk, JL, Hauser, EC, D'Azzo, A, Platt, FM, Seyfried, TN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c01b12a3980d1324092fd3e937e47b86
https://ora.ox.ac.uk/objects/uuid:094d2012-869a-4a9e-8f97-fa3505cf63a6

N-butyldeoxygalactonojirimycin reduces neonatal brain ganglioside content in a mouse model of GM1 gangliosidosis

Autor: Kasperzyk, JL, El-Abbadi, MM, Hauser, EC, D'Azzo, A, Platt, FM, Seyfried, TN

GM1 gangliosidosis is a glycosphingolipid (GSL) lysosomal storage disease caused by a genetic deficiency of acid beta-galactosidase (beta-gal), the enzyme that catabolyzes GM1 within lysosomes. Accumulation of GM1 and its asialo form (GA1) occurs pri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4997369d112628edafc1f5aef0b74baf
https://ora.ox.ac.uk/objects/uuid:1d8e4aa1-f7f8-4f89-bdb4-1b7390720b56

Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer?

Autor: Seyfried, TN, Marsh, J, Shelton, LM, Huysentruyt, LC, Mukherjee, P

Publikováno v: Seyfried, TN; Marsh, J; Shelton, LM; Huysentruyt, LC; & Mukherjee, P. (2012). Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer?. Epilepsy Research, 100(3), 310-326. doi: 10.1016/j.eplepsyres.2011.06.017. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7v8176q8

Malignant brain cancer persists as a major disease of morbidity and mortality. The failure to recognize brain cancer as a disease of energy metabolism has contributed in large part to the failure in management. As long as brain tumor cells have acces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::ba6a556dd44e314024e9feaa139df3aa
http://www.escholarship.org/uc/item/7v8176q8

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