Zobrazeno 1 - 10
of 8 114
pro vyhledávání: '"Seyfried AN"'
In our urbanised societies, the management and regulation of traffic and pedestrian flows is of considerable interest for public safety, economic development, and the conservation of the environment. However, modelling and controlling the collective
Externí odkaz:
http://arxiv.org/abs/2410.22896
Since the beginning of the century, capturing trajectories of pedestrian streams precisely from video recordings has been possible. To enable measurements at high density, the heads of the pedestrians are marked and tracked, thus providing a complete
Externí odkaz:
http://arxiv.org/abs/2409.11857
We investigate a new task in human motion prediction, which is predicting motions under unexpected physical perturbation potentially involving multiple people. Compared with existing research, this task involves predicting less controlled, unpremedit
Externí odkaz:
http://arxiv.org/abs/2403.15891
In high-density crowds, local motion can propagate, amplify, and lead to macroscopic phenomena, including 'density waves'. These density waves only occur when individuals interact, and impulses are transferred to neighbours. How this impulse is passe
Externí odkaz:
http://arxiv.org/abs/2402.19024
Analyzing the microscopic dynamics of pushing behavior within crowds can offer valuable insights into crowd patterns and interactions. By identifying instances of pushing in crowd videos, a deeper understanding of when, where, and why such behavior o
Externí odkaz:
http://arxiv.org/abs/2310.07416
Autor:
Tomás Duraj, Miriam Kalamian, Giulio Zuccoli, Joseph C. Maroon, Dominic P. D’Agostino, Adrienne C. Scheck, Angela Poff, Sebastian F. Winter, Jethro Hu, Rainer J. Klement, Alicia Hickson, Derek C. Lee, Isabella Cooper, Barbara Kofler, Kenneth A. Schwartz, Matthew C. L. Phillips, Colin E. Champ, Beth Zupec-Kania, Jocelyn Tan-Shalaby, Fabiano M. Serfaty, Egiroh Omene, Gabriel Arismendi-Morillo, Michael Kiebish, Richard Cheng, Ahmed M. El-Sakka, Axel Pflueger, Edward H. Mathews, Donese Worden, Hanping Shi, Raffaele Ivan Cincione, Jean Pierre Spinosa, Abdul Kadir Slocum, Mehmet Salih Iyikesici, Atsuo Yanagisawa, Geoffrey J. Pilkington, Anthony Chaffee, Wafaa Abdel-Hadi, Amr K. Elsamman, Pavel Klein, Keisuke Hagihara, Zsófia Clemens, George W. Yu, Athanasios E. Evangeliou, Janak K. Nathan, Kris Smith, David Fortin, Jorg Dietrich, Purna Mukherjee, Thomas N. Seyfried
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-49 (2024)
Abstract Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a universally lethal prognosis despite maximal standard therapies. Here, we present a consensus treatment protocol based on the metabolic requirements of GBM cells
Externí odkaz:
https://doaj.org/article/f493bd6a9af94b99a15a8ff738e02f2b
Autor:
Van-Cuong Pham, Claudia Jasmin Rödel, Mariaelena Valentino, Matteo Malinverno, Alessio Paolini, Juliane Münch, Candice Pasquier, Favour C Onyeogaziri, Bojana Lazovic, Romuald Girard, Janne Koskimäki, Melina Hußmann, Benjamin Keith, Daniel Jachimowicz, Franziska Kohl, Astrid Hagelkruys, Josef M Penninger, Stefan Schulte-Merker, Issam A Awad, Ryan Hicks, Peetra U Magnusson, Eva Faurobert, Massimiliano Pagani, Salim Abdelilah-Seyfried
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 11, Pp 2827-2855 (2024)
Abstract Cerebral cavernous malformations (CCMs) are anomalies of the cerebral vasculature. Loss of the CCM proteins CCM1/KRIT1, CCM2, or CCM3/PDCD10 trigger a MAPK-Krüppel-like factor 2 (KLF2) signaling cascade, which induces a pathophysiological p
Externí odkaz:
https://doaj.org/article/a3e67a3c4c2b45fb843c16dfd7fbb6eb
Autor:
Qi Guo, Lingyan Ping, Eric B. Dammer, Duc M. Duong, Luming Yin, Kaiming Xu, Anantharaman Shantaraman, Edward J. Fox, Todd E Golde, Erik C.B. Johnson, Blaine R. Roberts, James J. Lah, Allan I. Levey, Nicholas T. Seyfried
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-30 (2024)
Abstract Introduction Heparin binding proteins (HBPs) with roles in extracellular matrix assembly are strongly correlated to β-amyloid (Aβ) and tau pathology in Alzheimer’s disease (AD) brain and cerebrospinal fluid (CSF). However, it remains cha
Externí odkaz:
https://doaj.org/article/45c6f5f8193444e2b5dcf0ca69a39efd
Autor:
Zhang, Yi, Tutt, Fred, Evans, Guy N., Sharma, Prachi, Haugstad, Greg, Kaiser, Ben, Ramberger, Justin, Bayliff, Samuel, Tao, Yu, Manno, Mike, Garcia-Barriocanal, Javier, Chaturvedi, Vipul, Fernandes, Rafael M., Birol, Turan, Seyfried Jr., William E., Leighton, Chris
Despite their highly anisotropic complex-oxidic nature, certain delafossite compounds (e.g., PdCoO2, PtCoO2) are the most conductive oxides known, for reasons that remain poorly understood. Their room-temperature conductivity can exceed that of Au, w
Externí odkaz:
http://arxiv.org/abs/2308.14257
Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology
Autor:
Annie M. Goettemoeller, Emmie Banks, Prateek Kumar, Viktor J. Olah, Katharine E. McCann, Kelly South, Christina C. Ramelow, Anna Eaton, Duc M. Duong, Nicholas T. Seyfried, David Weinshenker, Srikant Rangaraju, Matthew J. M. Rowan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Preventative treatment for Alzheimer’s Disease (AD) is dire, yet mechanisms underlying early regional vulnerability remain unknown. In AD, one of the earliest pathophysiological correlates to cognitive decline is hyperexcitability, which i
Externí odkaz:
https://doaj.org/article/472c8a45309c4ce99d27485c1bbd846b