Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Seyed Mohammad Mahdi Rasa"'
Autor:
Omid Omrani, Anna Krepelova, Seyed Mohammad Mahdi Rasa, Dovydas Sirvinskas, Jing Lu, Francesco Annunziata, George Garside, Seerat Bajwa, Susanne Reinhardt, Lisa Adam, Sandra Käppel, Nadia Ducano, Daniela Donna, Alessandro Ori, Salvatore Oliviero, Karl Lenhard Rudolph, Francesco Neri
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The influence of aging on intestinal stem cells and their niche can explain underlying causes for perturbation in their function observed during aging. Molecular mechanisms for such a decrease in the functionality of intestinal stem cells du
Externí odkaz:
https://doaj.org/article/8d8b248d97c8482fa9a842f1ea32364e
Autor:
Jing Lu, Francesco Annunziata, Dovydas Sirvinskas, Omid Omrani, Huahui Li, Seyed Mohammad Mahdi Rasa, Anna Krepelova, Lisa Adam, Francesco Neri
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-15 (2022)
Abstract Background Patients with colon adenocarcinoma (COAD) exhibit significant heterogeneity in overall survival. The current tumor-node-metastasis staging system is insufficient to provide a precise prediction for prognosis. Identification and ev
Externí odkaz:
https://doaj.org/article/8ae347f47d394a3480383b0ef3b45248
Autor:
Omid Omrani, Anna Krepelova, Seyed Mohammad Mahdi Rasa, Dovydas Sirvinskas, Jing Lu, Francesco Annunziata, George Garside, Seerat Bajwa, Susanne Reinhardt, Lisa Adam, Sandra Käppel, Nadia Ducano, Daniela Donna, Alessandro Ori, Salvatore Oliviero, Karl Lenhard Rudolph, Francesco Neri
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/e06ca408d7a64681aa20ea29601b042a
Autor:
Francesco Annunziata, Seyed Mohammad Mahdi Rasa, Anna Krepelova, Jing Lu, Alberto Minetti, Omid Omrani, Suneetha Nunna, Lisa Adam, Sandra Käppel, Francesco Neri
Publikováno v:
European Journal of Cell Biology, Vol 101, Iss 4, Pp 151282- (2022)
Calorie restriction has been recently shown to increase intestinal stem cell competition and to reduce mutation fixation in young mice. However, the impact of aging on this process is unknown. By employing Confetti reporter mice, here we show that, u
Externí odkaz:
https://doaj.org/article/72732d0371f245d9855f83d915cd0463
Autor:
Jing Lu, Anna Krepelova, Seyed Mohammad Mahdi Rasa, Francesco Annunziata, Olena Husak, Lisa Adam, Suneetha Nunna, Francesco Neri
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Organoids culture provides unique opportunities to study human diseases and to complement animal models. Several organs and tissues can be in vitro cultured in 3D structures resembling in vivo tissue organization. Organoids culture contains
Externí odkaz:
https://doaj.org/article/922f51cd44344c1fa5a78e768fd26719
Autor:
Tim Schomann, Kimia Mirzakhani, Julia Kallenbach, Jing Lu, Seyed Mohammad Mahdi Rasa, Francesco Neri, Aria Baniahmad
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1048 (2022)
The bipolar androgen therapy (BAT) includes the treatment of prostate cancer (PCa) patients with supraphysiological androgen level (SAL). Interestingly, SAL induces cell senescence in PCa cell lines as well as ex vivo in tumor samples of patients. Th
Externí odkaz:
https://doaj.org/article/db81f71d360a48fa984985a502a6768b
Autor:
Alicia Tapias, David Lázaro, Bo-Kun Yin, Seyed Mohammad Mahdi Rasa, Anna Krepelova, Erika Kelmer Sacramento, Paulius Grigaravicius, Philipp Koch, Joanna Kirkpatrick, Alessandro Ori, Francesco Neri, Zhao-Qi Wang
Publikováno v:
eLife, Vol 10 (2021)
Brain homeostasis is regulated by the viability and functionality of neurons. HAT (histone acetyltransferase) and HDAC (histone deacetylase) inhibitors have been applied to treat neurological deficits in humans; yet, the epigenetic regulation in neur
Externí odkaz:
https://doaj.org/article/33e304c7257749b2a06dea0c9d2f2260
Autor:
Mohammad Dabaghi, Seyed Mohammad Mahdi Rasa, Emilio Cirri, Alessandro Ori, Francesco Neri, Rainer Quaas, Ingrid Hilger
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1625 (2021)
In this study we looked for the main protein pathway regulators which were responsible for the therapeutic impact on colon cancers when combining magnetic hyperthermia with the chemotherapeutic agent 5-fluorouracil (5FU). To this end, chitosan-coated
Externí odkaz:
https://doaj.org/article/536977fbce314dfebcddc733341a83d5
Autor:
Anna Melekhova, Mirjam Leeder, Thanakorn Pungsrinont, Tim Schmäche, Julia Kallenbach, Marzieh Ehsani, Kimia Mirzakhani, Seyed Mohammad Mahdi Rasa, Francesco Neri, Aria Baniahmad
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1152 (2021)
Inhibitor of growth 3 (ING3) is one of five members of the ING tumour suppressor family, characterized by a highly conserved plant homeodomain (PHD) as a reader of the histone mark H3K4me3. ING3 was reported to act as a tumour suppressor in many diff
Externí odkaz:
https://doaj.org/article/8c58cf88a46f4fe7add927b0f5e7697b
Autor:
Chiara Cencioni, Johanna Heid, Anna Krepelova, Seyed Mohammad Mahdi Rasa, Carsten Kuenne, Stefan Guenther, Mario Baumgart, Alessandro Cellerino, Francesco Neri, Francesco Spallotta, Carlo Gaetano
Publikováno v:
Cells, Vol 8, Iss 10, p 1169 (2019)
Aging associates with progressive loss of skeletal muscle function, sometimes leading to sarcopenia, a process characterized by impaired mobility and weakening of muscle strength. Since aging associates with profound epigenetic changes, epigenetic la
Externí odkaz:
https://doaj.org/article/fb64c7f7c0504cdcbbea1e962c9ebeec