Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Seychelle M. Vos"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Acetylation of histones is a key post-translational modification that guides gene expression regulation. In yeast, the class I histone deacetylase containing Rpd3S complex plays a critical role in the suppression of spurious transcription by
Externí odkaz:
https://doaj.org/article/25f4262cf2a54df2931234c5accfc355
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
Eukaryotic transcription requires passage of RNA polymerase II (Pol II) through chromatin, which is impaired by nucleosomes. Here the authors report the cryo-EM structure of transcribing Pol II engaged with a downstream nucleosome core particle at an
Externí odkaz:
https://doaj.org/article/f832447ece5a402da1f4a0d40d65ef34
Autor:
Sofia Battaglia, Michael Lidschreiber, Carlo Baejen, Phillipp Torkler, Seychelle M Vos, Patrick Cramer
Publikováno v:
eLife, Vol 6 (2017)
For transcription through chromatin, RNA polymerase (Pol) II associates with elongation factors (EFs). Here we show that many EFs crosslink to RNA emerging from transcribing Pol II in the yeast Saccharomyces cerevisiae. Most EFs crosslink preferentia
Externí odkaz:
https://doaj.org/article/e7db3bfd4b324548acadfae3d2e47a88
Publikováno v:
Curr Opin Struct Biol
Transcription is the first step of gene expression and involves RNA polymerases. After transcription initiation, RNA polymerase enters elongation followed by transcription termination at the end of the gene. Only recently, structures of transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30a83c73e03c6ba375fce0ecb3a7dda
https://europepmc.org/articles/PMC9398977/
https://europepmc.org/articles/PMC9398977/
Autor:
Yilai Li, Quanfu Fan, Ziping Xu, Emma Rose Lee, John Cohn, Veronique Demers, Ja Young Lee, Lucy Yip, Michael A. Cianfrocco, Seychelle M. Vos
Cryo-electron microscopy (cryo-EM) represents a powerful technology for determining atomic models of biological macromolecules(Kühlbrandt, 2014). Despite this promise, human-guided cryo-EM data collection practices limit the impact of cryo-EM becaus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4529bc55f245d54fa063af88e65a2549
https://doi.org/10.1101/2022.06.17.496614
https://doi.org/10.1101/2022.06.17.496614
Publikováno v:
Science
In eukaryotes, RNA polymerase (Pol) II transcribes chromatin and must move past nucleosomes, often resulting in nucleosome displacement. How Pol II unwraps the DNA from nucleosomes to allow transcription and how DNA rewraps to retain nucleosomes has
Autor:
Seychelle M. Vos
Publikováno v:
Prof. Seychelle Vos
The influence of genome organization on transcription is central to our understanding of cell type specification. Higher-order genome organization is established through short- and long-range DNA interactions. Coordination of these interactions, from
Autor:
Seychelle M. Vos, Patrick Cramer, Dmitry E. Agafonov, Suyang Zhang, Shintaro Aibara, Reinhard Lührmann
Publikováno v:
Science
science
science
A tight couple makes messenger RNAs Gene expression in eukaryotes first requires transcription of DNA to an RNA copy and then splicing to form the final, processed messenger RNA (mRNA). Zhang et al. investigated how gene transcription and RNA splicin
Autor:
Seychelle M Vos, David Pöllmann, Livia Caizzi, Katharina B Hofmann, Pascaline Rombaut, Tomasz Zimniak, Franz Herzog, Patrick Cramer
Publikováno v:
eLife, Vol 5 (2016)
Transcription regulation in metazoans often involves promoter-proximal pausing of RNA polymerase (Pol) II, which requires the 4-subunit negative elongation factor (NELF). Here we discern the functional architecture of human NELF through X-ray crystal
Externí odkaz:
https://doaj.org/article/caf7bfc79a114ab4a6e1952f7a1bedf4
Autor:
Seychelle M, Vos
Publikováno v:
Nature structuralmolecular biology. 28(12)