K128 ubiquitination constrains RAS activity by expanding its binding interface with GAP proteins.

Autor: Magits W; VIB-KU Leuven Center for Cancer Biology, VIB, 3000, Leuven, Belgium., Steklov M; VIB-KU Leuven Center for Cancer Biology, VIB, 3000, Leuven, Belgium., Jang H; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research in the Laboratory of Cancer ImmunoMetabolism, National Cancer Institute, Frederick, MD, 21702, USA., Sewduth RN; VIB-KU Leuven Center for Cancer Biology, VIB, 3000, Leuven, Belgium.; Department of Oncology, KU Leuven, 3000, Leuven, Belgium., Florentin A; School of Neurobiology, Biochemistry & Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, 69978, Tel Aviv, Israel., Lechat B; VIB-KU Leuven Center for Cancer Biology, VIB, 3000, Leuven, Belgium., Sheryazdanova A; VIB-KU Leuven Center for Cancer Biology, VIB, 3000, Leuven, Belgium., Zhang M; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research in the Laboratory of Cancer ImmunoMetabolism, National Cancer Institute, Frederick, MD, 21702, USA., Simicek M; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic., Prag G; School of Neurobiology, Biochemistry & Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, 69978, Tel Aviv, Israel., Nussinov R; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research in the Laboratory of Cancer ImmunoMetabolism, National Cancer Institute, Frederick, MD, 21702, USA.; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel., Sablina A; VIB-KU Leuven Center for Cancer Biology, VIB, 3000, Leuven, Belgium. anna.sablina@kuleuven.be.; Department of Oncology, KU Leuven, 3000, Leuven, Belgium. anna.sablina@kuleuven.be.

Publikováno v: The EMBO journal [EMBO J] 2024 Jul; Vol. 43 (14), pp. 2862-2877. Date of Electronic Publication: 2024 Jun 10.

Spatial Mechano-Signaling Regulation of GTPases through Non-Degradative Ubiquitination.

Autor: Sewduth RN; VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, 3000, Belgium.; Department of Oncology, KU Leuven, Herestraat 49, Leuven, 3000, Belgium., Carai P; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Herestraat 49, Leuven, 3000, Belgium., Ivanisevic T; VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, 3000, Belgium.; Department of Oncology, KU Leuven, Herestraat 49, Leuven, 3000, Belgium., Zhang M; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research in the Laboratory of Cancer ImmunoMetabolism, National Cancer Institute, Frederick, MD, 21702, USA., Jang H; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research in the Laboratory of Cancer ImmunoMetabolism, National Cancer Institute, Frederick, MD, 21702, USA., Lechat B; VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, 3000, Belgium.; Department of Oncology, KU Leuven, Herestraat 49, Leuven, 3000, Belgium., Van Haver D; VIB-UGent Center for Medical Biotechnology, Technologiepark-Zwijnaarde 75, Ghent, 9052, Belgium.; Department of Biomolecular Medicine, Ghent University, Technologiepark-Zwijnaarde 75, Ghent, 9052, Belgium.; VIB Proteomics Core, Technologiepark-Zwijnaarde 75, Ghent, 9052, Belgium., Impens F; VIB-UGent Center for Medical Biotechnology, Technologiepark-Zwijnaarde 75, Ghent, 9052, Belgium.; Department of Biomolecular Medicine, Ghent University, Technologiepark-Zwijnaarde 75, Ghent, 9052, Belgium.; VIB Proteomics Core, Technologiepark-Zwijnaarde 75, Ghent, 9052, Belgium., Nussinov R; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research in the Laboratory of Cancer ImmunoMetabolism, National Cancer Institute, Frederick, MD, 21702, USA.; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel., Jones E; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Herestraat 49, Leuven, 3000, Belgium.; Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, Universiteitssingel 50, Maastricht, 6229 ER, The Netherlands., Sablina A; VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, 3000, Belgium.; Department of Oncology, KU Leuven, Herestraat 49, Leuven, 3000, Belgium.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2023 Dec; Vol. 10 (36), pp. e2303367. Date of Electronic Publication: 2023 Nov 09.

Multi-Omics Integration for the Design of Novel Therapies and the Identification of Novel Biomarkers.

Autor: Ivanisevic T; VIB-KU Leuven Center for Cancer Biology (VIB), 3000 Leuven, Belgium., Sewduth RN; VIB-KU Leuven Center for Cancer Biology (VIB), 3000 Leuven, Belgium.

Publikováno v: Proteomes [Proteomes] 2023 Oct 20; Vol. 11 (4). Date of Electronic Publication: 2023 Oct 20.

Loss-of-Function Mutations in TRAF7 and KLF4 Cooperatively Activate RAS-Like GTPase Signaling and Promote Meningioma Development.

Autor: Najm P; VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Zhao P; VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Steklov M; VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Sewduth RN; VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Baietti MF; VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Pandolfi S; VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Criem N; VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Lechat B; VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Maia TM; VIB Center for Medical Biotechnology, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; VIB Proteomics Core, VIB-UGent Center for Medical Biotechnology, Ghent, Belgium., Van Haver D; VIB Center for Medical Biotechnology, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; VIB Proteomics Core, VIB-UGent Center for Medical Biotechnology, Ghent, Belgium., Corthout N; VIB LiMoNe & Leuven Bio Imaging Core, VIB-KU Leuven Center For Brain & Disease Research, Leuven, Belgium., Eyckerman S; VIB Center for Medical Biotechnology, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium., Impens F; VIB Center for Medical Biotechnology, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; VIB Proteomics Core, VIB-UGent Center for Medical Biotechnology, Ghent, Belgium., Sablina AA; VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium. anna.sablina@cme.vib-kuleuven.be.; Department of Oncology, KU Leuven, Leuven, Belgium.

Publikováno v: Cancer research [Cancer Res] 2021 Aug 15; Vol. 81 (16), pp. 4218-4229. Date of Electronic Publication: 2021 Jul 02.

The Noonan Syndrome Gene Lztr1 Controls Cardiovascular Function by Regulating Vesicular Trafficking.

Autor: Sewduth RN; From the VIB-KU Leuven Center for Cancer Biology, Belgium (R.N.S., S.P., M.S., A.S., P.Z., N.C., M.F.B., B.L., A.A.S.).; Department of Oncology, KU Leuven, Belgium (R.N.S., S.P., M.S., A.S., P.Z., N.C., M.F.B., B.L., A.A.S.)., Pandolfi S; From the VIB-KU Leuven Center for Cancer Biology, Belgium (R.N.S., S.P., M.S., A.S., P.Z., N.C., M.F.B., B.L., A.A.S.).; Department of Oncology, KU Leuven, Belgium (R.N.S., S.P., M.S., A.S., P.Z., N.C., M.F.B., B.L., A.A.S.)., Steklov M; From the VIB-KU Leuven Center for Cancer Biology, Belgium (R.N.S., S.P., M.S., A.S., P.Z., N.C., M.F.B., B.L., A.A.S.).; Department of Oncology, KU Leuven, Belgium (R.N.S., S.P., M.S., A.S., P.Z., N.C., M.F.B., B.L., A.A.S.)., Sheryazdanova A; From the VIB-KU Leuven Center for Cancer Biology, Belgium (R.N.S., S.P., M.S., A.S., P.Z., N.C., M.F.B., B.L., A.A.S.).; Department of Oncology, KU Leuven, Belgium (R.N.S., S.P., M.S., A.S., P.Z., N.C., M.F.B., B.L., A.A.S.)., Zhao P; From the VIB-KU Leuven Center for Cancer Biology, Belgium (R.N.S., S.P., M.S., A.S., P.Z., N.C., M.F.B., B.L., A.A.S.).; Department of Oncology, KU Leuven, Belgium (R.N.S., S.P., M.S., A.S., P.Z., N.C., M.F.B., B.L., A.A.S.)., Criem N; From the VIB-KU Leuven Center for Cancer Biology, Belgium (R.N.S., S.P., M.S., A.S., P.Z., N.C., M.F.B., B.L., A.A.S.).; Department of Oncology, KU Leuven, Belgium (R.N.S., S.P., M.S., A.S., P.Z., N.C., M.F.B., B.L., A.A.S.)., Baietti MF; From the VIB-KU Leuven Center for Cancer Biology, Belgium (R.N.S., S.P., M.S., A.S., P.Z., N.C., M.F.B., B.L., A.A.S.).; Department of Oncology, KU Leuven, Belgium (R.N.S., S.P., M.S., A.S., P.Z., N.C., M.F.B., B.L., A.A.S.)., Lechat B; From the VIB-KU Leuven Center for Cancer Biology, Belgium (R.N.S., S.P., M.S., A.S., P.Z., N.C., M.F.B., B.L., A.A.S.).; Department of Oncology, KU Leuven, Belgium (R.N.S., S.P., M.S., A.S., P.Z., N.C., M.F.B., B.L., A.A.S.)., Quarck R; University Hospitals and Department of Chronic Diseases, Metabolism & Ageing (CHROMETA), KU Leuven, Belgium (R.Q.)., Impens F; Department of Biomolecular Medicine, Ghent University, Belgium (F.I.).; VIB Center for Medical Biotechnology, Belgium (F.I.).; VIB Proteomics Core, Albert Baertsoenkaai 3, Belgium (F.I.)., Sablina AA; From the VIB-KU Leuven Center for Cancer Biology, Belgium (R.N.S., S.P., M.S., A.S., P.Z., N.C., M.F.B., B.L., A.A.S.).; Department of Oncology, KU Leuven, Belgium (R.N.S., S.P., M.S., A.S., P.Z., N.C., M.F.B., B.L., A.A.S.).

Publikováno v: Circulation research [Circ Res] 2020 May 08; Vol. 126 (10), pp. 1379-1393. Date of Electronic Publication: 2020 Mar 16.