Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sewar Alkhashrom"'
Autor:
Isabelle Aillaud, Senthilvelrajan Kaniyappan, Ram Reddy Chandupatla, Lisa Marie Ramirez, Sewar Alkhashrom, Jutta Eichler, Anselm H. C. Horn, Markus Zweckstetter, Eckhard Mandelkow, Heinrich Sticht, Susanne Aileen Funke
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-19 (2022)
Abstract Background Alzheimer’s disease (AD), the most common form of dementia, is a progressive neurodegenerative disorder that mainly affects older adults. One of the pathological hallmarks of AD is abnormally aggregated Tau protein that forms fi
Externí odkaz:
https://doaj.org/article/be7a9b4f92e14cbdb3ebad08765e0077
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Protein stability limitations often hamper the exploration of proteins as drug targets. Here, we show that the application of PROSS server algorithms to the ligand-binding domain of human estrogen receptor alpha (hERα) enabled the developme
Externí odkaz:
https://doaj.org/article/c81ef6036eec4309827b94dcc2a035d3
Autor:
Sewar Alkhashrom, Jintawee Kicuntod, Katharina Stillger, Tamara Lützenburg, Christian Anzenhofer, Ines Neundorf, Manfred Marschall, Jutta Eichler
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1040 (2022)
The replication of human cytomegalovirus (HCMV) involves a process termed nuclear egress, which enables translocation of newly formed viral capsids from the nucleus into the cytoplasm. The HCMV core nuclear egress complex (core NEC), a heterodimer of
Externí odkaz:
https://doaj.org/article/3cf3b52baba4452698d2aa20abc57a92
Autor:
Jintawee Kicuntod, Sewar Alkhashrom, Sigrun Häge, Benedikt Diewald, Regina Müller, Friedrich Hahn, Peter Lischka, Heinrich Sticht, Jutta Eichler, Manfred Marschall
Publikováno v:
Viruses, Vol 13, Iss 3, p 462 (2021)
Herpesviral nuclear egress is a regulated process shared by all family members, ensuring the efficient cytoplasmic release of viral capsids. In the case of human cytomegalovirus (HCMV), the core of the nuclear egress complex (NEC) consists of the pUL
Externí odkaz:
https://doaj.org/article/9f708b6a453a43288dfff2b5708a73f9
Autor:
Sewar Alkhashrom, Jintawee Kicuntod, Sigrun Häge, Johannes Schweininger, Yves A. Muller, Peter Lischka, Manfred Marschall, Jutta Eichler
Publikováno v:
Viruses, Vol 13, Iss 3, p 471 (2021)
Nuclear egress is an essential process in the replication of human cytomegalovirus (HCMV), as it enables the migration of newly formed viral capsids from the nucleus into the cytoplasm. Inhibition of the HCMV core nuclear egress complex (core NEC), c
Externí odkaz:
https://doaj.org/article/ed4e6ba6b5fc4389ab99a2045db689a7
Autor:
Manfred Marschall, Sigrun Häge, Marcus Conrad, Sewar Alkhashrom, Jintawee Kicuntod, Johannes Schweininger, Mark Kriegel, Josephine Lösing, Julia Tillmanns, Frank Neipel, Jutta Eichler, Yves A. Muller, Heinrich Sticht
Publikováno v:
Viruses, Vol 12, Iss 6, p 683 (2020)
Herpesviruses uniquely express two essential nuclear egress-regulating proteins forming a heterodimeric nuclear egress complex (core NEC). These core NECs serve as hexameric lattice-structured platforms for capsid docking and recruit viral and cellul
Externí odkaz:
https://doaj.org/article/1f7f9a819ff04dc3a8da54471832bd4c
Autor:
Claudia Egerer-Sieber, Julia Tillmanns, T. Lenac Rovis, Sewar Alkhashrom, Heinrich Sticht, Marcus Conrad, Manfred Marschall, Yves A. Muller, Sigrid Weiler, Johannes Schweininger, A. Decker, Mark Kriegel, Sigrun Häge, Josephine Lösing, Jutta Eichler
Varicella zoster virus (VZV) is a human pathogen from the α-subfamily of herpesviruses. Here, the crystal structure of the VZV Orf24-Orf27 complex is described, representing the essential viral core nuclear egress complex (NEC) that orchestrates the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cef2aa8703f45d087c216452d6a30474
https://doi.org/10.1101/2021.08.23.457313
https://doi.org/10.1101/2021.08.23.457313
Autor:
Johannes Schweininger, Mark Kriegel, Sigrun Häge, Marcus Conrad, Sewar Alkhashrom, Josephine Lösing, Sigrid Weiler, Julia Tillmanns, Claudia Egerer-Sieber, Andrea Decker, Tihana Lenac Roviš, Jutta Eichler, Heinrich Sticht, Manfred Marschall, Yves A. Muller
Publikováno v:
Journal of Biological Chemistry
Volume 298
Issue 3
The journal of biological chemistry 298(3), 101625 (2022). doi:10.1016/j.jbc.2022.101625
Volume 298
Issue 3
The journal of biological chemistry 298(3), 101625 (2022). doi:10.1016/j.jbc.2022.101625
The journal of biological chemistry 298(3), 101625 (2022). doi:10.1016/j.jbc.2022.101625
Varicella-zoster virus (VZV) is a human pathogen from the α-subfamily of herpesviruses. The VZV Orf24-Orf27 complex represents the essential viral core nuc
Varicella-zoster virus (VZV) is a human pathogen from the α-subfamily of herpesviruses. The VZV Orf24-Orf27 complex represents the essential viral core nuc
Autor:
Josephine Lösing, Kerstin Hof, Sascha A. Walzer, Stephanie Holst, Sebastian Weigert, Claudia Egerer-Sieber, Yves A. Muller, Simon Dolles, Tobias Höllriegl, Sigrun Häge, Jutta Eichler, Marcus Conrad, Sewar Alkhashrom, Heinrich Sticht, Manfred Marschall, Eric Sonntag
Publikováno v:
J Biol Chem
Herpesviruses uniquely express two essential nuclear egress-regulating proteins forming a heterodimeric basic structure of the nuclear egress complex (core NEC). These core NECs serve as a hexameric lattice-structured platform for capsid docking and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf2e710d0285642d04f1065e3e24fd8
https://europepmc.org/articles/PMC7062154/
https://europepmc.org/articles/PMC7062154/