Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Sew Y. Peak-Chew"'
Autor:
Holly Kay, Ellen Grünewald, Helen K. Feord, Sergio Gil, Sew Y. Peak-Chew, Alessandra Stangherlin, John S. O’Neill, Gerben van Ooijen
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Holly Kay, Ellen Grünewald, et al. provide an in-depth examination of the proteome in the eukaryotic green alga, Ostreococcus tauri, under circadian constant light or cycling diurnal light-dark conditions. They observe that there is little overlap b
Externí odkaz:
https://doaj.org/article/5d1cd59dcc7e47d8a24083d7cbcd5956
Autor:
John J. H. Shin, Oliver M. Crook, Alicia C. Borgeaud, Jérôme Cattin-Ortolá, Sew Y. Peak-Chew, Lisa M. Breckels, Alison K. Gillingham, Jessica Chadwick, Kathryn S. Lilley, Sean Munro
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The vesicles that transport proteins between intracellular organelles are small, short-lived, and elusive. Here, the authors show that capture of these vesicles through relocalizing tethers to mitochondria allows their contents to be characterised by
Externí odkaz:
https://doaj.org/article/1913f75e498144daac7560db0fab4bbd
Autor:
John S. O’ Neill, Nathaniel P. Hoyle, J. Brian Robertson, Rachel S. Edgar, Andrew D. Beale, Sew Y. Peak-Chew, Jason Day, Ana S. H. Costa, Christian Frezza, Helen C. Causton
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Yeast exhibit oscillations that share features with circadian rhythms. The authors show that bioenergetic constraints promote oscillatory behaviour: resources are stored until supplies can support translational bursting, this is licensed by ion trans
Externí odkaz:
https://doaj.org/article/5f80bcd8c3434476af92702098c2e29a
Autor:
John S. O’Neill, Nathaniel P. Hoyle, J. Brian Robertson, Rachel S. Edgar, Andrew D. Beale, Sew Y. Peak-Chew, Jason Day, Ana S. H. Costa, Christian Frezza, Helen C. Causton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/3d8511efe6754e5abea861c8a3360cef
Autor:
Alessandra Stangherlin, Helen K. Feord, John S. O’Neill, Ellen Grünewald, Gerben van Ooijen, Holly Kay, Sew Y. Peak-Chew, Sergio Gil
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Kay, H, Grünewald, E, Feord, H K, Gil, S, Peak-Chew, S Y, Stangherlin, A, O’Neill, J S & Van Ooijen, G 2021, ' Deep-coverage spatiotemporal proteome of the picoeukaryote ostreococcus tauri reveals differential effects of environmental and endogenous 24-hour rhythms ', Communications biology, vol. 4, no. 1, 1147 . https://doi.org/10.1038/s42003-021-02680-3
Communications Biology
Kay, H, Grünewald, E, Feord, H K, Gil, S, Peak-Chew, S Y, Stangherlin, A, O’Neill, J S & Van Ooijen, G 2021, ' Deep-coverage spatiotemporal proteome of the picoeukaryote ostreococcus tauri reveals differential effects of environmental and endogenous 24-hour rhythms ', Communications biology, vol. 4, no. 1, 1147 . https://doi.org/10.1038/s42003-021-02680-3
Communications Biology
The cellular landscape changes dramatically over the course of a 24 h day. The proteome responds directly to daily environmental cycles and is additionally regulated by the circadian clock. To quantify the relative contribution of diurnal versus circ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8727824ad637ad35a6e4924f0647d61e
https://doaj.org/article/5d1cd59dcc7e47d8a24083d7cbcd5956
https://doaj.org/article/5d1cd59dcc7e47d8a24083d7cbcd5956
Autor:
Yang Yang, Wenjuan Zhang, Alexey G. Murzin, Manuel Schweighauser, Melissa Huang, Sofia Lövestam, Sew Y. Peak-Chew, Takashi Saito, Takaomi C. Saido, Jennifer Macdonald, Isabelle Lavenir, Bernardino Ghetti, Caroline Graff, Amit Kumar, Agneta Nordberg, Michel Goedert, Sjors H. W. Scheres
Publikováno v:
Acta neuropathologica.
Funder: Biotechnology and Biological Sciences Research Council; doi: http://dx.doi.org/10.13039/501100000268
The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in amyloid-β (Aβ)], causes dominantly inherited
The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in amyloid-β (Aβ)], causes dominantly inherited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084ff36d086a4dcbffb5d0983f871c89
https://pubmed.ncbi.nlm.nih.gov/36611124
https://pubmed.ncbi.nlm.nih.gov/36611124
Autor:
Estere Seinkmane, Sew Y Peak-Chew, Aiwei Zeng, Nina M Rzechorzek, Andrew D Beale, David CS Wong, John S O’Neill
Although costly to maintain, protein homeostasis is indispensable for normal cellular function and long-term health. In mammalian cells and tissues, daily variation in global protein synthesis has been observed, but its utility and consequences for p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6aae37189b34fef8dac1eddecfa39833
https://doi.org/10.1101/2022.09.30.509905
https://doi.org/10.1101/2022.09.30.509905
Autor:
John S. O’Neill, Christine T. Styles, Nina M Rzechorzek, Marrit Putker, Andrew D. Beale, Alessandra Stangherlin, Martin Reed, Aiwei Zeng, Jason Day, Sew Y. Peak-Chew, David C S Wong, Rachel S. Edgar, Estere Seinkmane
Publikováno v:
The EMBO Journal
Wong, D C S, Seinkmane, E, Zeng, A, Stangherlin, A, Rzechorzek, N, Beale, A D, Day, J, Reed, M, Peak-Chew, S Y, Styles, C T, Edgar, R S, Putker, M & O'Neill, J S 2021, ' CRYPTOCHROMES promote daily protein homeostasis ', EMBO Journal, vol. 41, no. 1, e108883 . https://doi.org/10.15252/embj.2021108883
Wong, D C S, Seinkmane, E, Zeng, A, Stangherlin, A, Rzechorzek, N, Beale, A D, Day, J, Reed, M, Peak-Chew, S Y, Styles, C T, Edgar, R S, Putker, M & O'Neill, J S 2021, ' CRYPTOCHROMES promote daily protein homeostasis ', EMBO Journal, vol. 41, no. 1, e108883 . https://doi.org/10.15252/embj.2021108883
The daily organisation of most mammalian cellular functions is attributed to circadian regulation of clock‐controlled protein expression, driven by daily cycles of CRYPTOCHROME‐dependent transcriptional feedback repression. To test this, we used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a757d2bf8d8f4257af1898e1cc167bc
https://www.repository.cam.ac.uk/handle/1810/331459
https://www.repository.cam.ac.uk/handle/1810/331459
Autor:
J. Brian Robertson, Andrew D. Beale, Rachel S. Edgar, Ana S. H. Costa, Helen C. Causton, Nathaniel P. Hoyle, John S. O’ Neill, Christian Frezza, Jason Day, Sew Y. Peak-Chew
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Yeast physiology is temporally regulated, this becomes apparent under nutrient-limited conditions and results in respiratory oscillations (YROs). YROs share features with circadian rhythms and interact with, but are independent of, the cell division
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c7644ad361199977c3ec3fc33c80c5
Autor:
Alexey G. Murzin, Wenjuan Zhang, Melissa Huang, Kathy L. Newell, Isabelle Lavenir, Ellen Gelpi, Bernardino Ghetti, Sofia Lövestam, Michel Goedert, Holly J. Garringer, Sew Y. Peak-Chew, Abhay Kotecha, Benjamin Falcon, Yang Yang, Jennifer A. Macdonald, Gabor G. Kovacs, Sjors H.W. Scheres, Manuel Schweighauser, Diana Arseni, Ruben Vidal
Publikováno v:
Science
Filament assembly of amyloid-β peptides ending at residue 42 (Aβ42) is a central event in Alzheimer’s disease. We report the cryo-EM structures of Aβ42 filaments from brain. Two structurally related S-shaped protofilament folds give rise to two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a48e57feff85f04c66cbb2d57cbd196
https://doi.org/10.1101/2021.10.19.464936
https://doi.org/10.1101/2021.10.19.464936