Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sevnur Kömürlü"'
Autor:
Molly Ohainle, Kyusik Kim, Sevnur Komurlu Keceli, Abby Felton, Ed Campbell, Jeremy Luban, Michael Emerman
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008507 (2020)
The HIV-1 capsid protein makes up the core of the virion and plays a critical role in early steps of HIV replication. Due to its exposure in the cytoplasm after entry, HIV capsid is a target for host cell factors that act directly to block infection
Externí odkaz:
https://doaj.org/article/56449c626528435f8ac1d4272bb5a066
Autor:
Sevnur Kömürlü, Margret Bradley, Nikolai Smolin, Sabrina Imam, Raymond F Pauszek, Seth L Robia, David Millar, Emi E Nakayama, Tatsuo Shioda, Edward M Campbell
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0212888 (2019)
TRIM5α is an interferon inducible restriction factor which contributes to intrinsic defense against HIV infection by targeting the HIV capsid protein CA. Although human TRIM5α (huTRIM5α) does not potently inhibit HIV-1 infection, the ability of hu
Externí odkaz:
https://doaj.org/article/cb7efc497121450da84a870033e43ddf
Autor:
Edward M. Campbell, Anastasia Selyutina, Sabrina Imam, Jessica Mattick, Sevnur Kömürlü, Felipe Diaz-Griffero, Amani Eddins, Sarah Talley
Publikováno v:
Journal of Virology. 93
TRIM5α is an antiviral restriction factor that inhibits retroviral infection in a species-specific fashion. TRIM5α binds to and forms assemblies around the retroviral capsid. Following binding, poorly understood, ubiquitin-dependent events lead to
Autor:
Sevnur Kömürlü, Felipe Diaz-Griffero, Anastasia Selyutina, Edward M. Campbell, Caterina Strambio-De-Castillia, Ann Dauphin, Leonid Yurkovetskiy, Kyusik Kim, Angel Bulnes-Ramos, Claudia Carbone, Jeremy Luban, Sean M. McCauley, William E. Diehl
Publikováno v:
Nature microbiology
The capsid (CA) protein lattice of HIV-1 and other retroviruses encases viral genomic RNA and regulates steps that are essential to retroviral invasion of target cells, including reverse transcription, nuclear trafficking, and integration of viral cD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76e2ad3f50c67e7cb69e870dd3d8db3
https://doi.org/10.1101/587907
https://doi.org/10.1101/587907
Autor:
Margret Bradley, Sevnur Kömürlü, Sabrina Imam, Tatsuo Shioda, David P. Millar, Raymond F. Pauszek, Edward M. Campbell, Emi E. Nakayama, Seth L. Robia, Nikolai Smolin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 3, p e0212888 (2019)
PLoS ONE, Vol 14, Iss 3, p e0212888 (2019)
TRIM5α is an interferon inducible restriction factor which contributes to intrinsic defense against HIV infection by targeting the HIV capsid protein CA. Although human TRIM5α (huTRIM5α) does not potently inhibit HIV-1 infection, the ability of hu
Akademický článek
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Autor:
Sergei Tretiak, Sebastian Fernandez-Alberti, Sevnur Kömürlü, Valeria D. Kleiman, D. Ondarse-Alvarez, Gustavo Pierdominici-Sottile, Adrian E. Roitberg
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Dendrimers are arrays of coupled chromophores, where the energy of each unit depends on its structure and conformation. The light harvesting and energy funneling properties are strongly dependent on their highly branched conjugated architecture. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38385073aaf2ca838e30a4317b8f5585
https://pubs.rsc.org/en/Content/ArticleLanding/2016/CP/C6CP04448D
https://pubs.rsc.org/en/Content/ArticleLanding/2016/CP/C6CP04448D
Autor:
Valeria D. Kleiman, Kirk S. Schanze, Tracy D. McCarley, Sung Won Cho, Adrian E. Roitberg, Sevnur Kömürlü, Fude Feng, Seoung Ho Lee
Publikováno v:
Langmuir. 28:16679-16691
Conjugated polyelectrolyte dendrimers (CPDs) are monodisperse macromolecules that feature a fully π-conjugated dendrimer core surrounded on the periphery by ionic solubilizing groups. CPDs are soluble in water and polar organic solvents, and they ex
Autor:
Sevnur Kömürlü, Valeria D. Kleiman, Xiaoyong Zhao, Gustavo Moriena, Hui Jiang, Seoung Ho Lee, Kirk S. Schanze
Publikováno v:
Macromolecules. 44:4742-4751
A new series of conjugated polyelectrolytes (CPE) consisting of an arylene–ethynylene backbone featuring phenyl (Ph), 2,1,3-benzothiadiazole (BTD), or 4,7-bis(2′-thienyl)-2,1,3-benzothiadiazole (TBT) units have been synthesized and characterized.
Autor:
Barbie K. Ganser-Pornillos, Edward M. Campbell, Damian Dawidowski, Santanu Mukherjee, Jacek Plewka, David S. Cafiso, Owen Pornillos, Steven L. Alam, Marcin D. Roganowicz, Yueping Wan, Sevnur Kömürlü, Katarzyna Skorupka
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006686 (2017)
PLoS Pathogens
PLoS Pathogens
Restriction factors are important components of intrinsic cellular defense mechanisms against viral pathogens. TRIM5α is a restriction factor that intercepts the incoming capsid cores of retroviruses such as HIV and provides an effective species-spe