Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sevinj Isgandrova"'
Autor:
Xian-De Liu, Wen Kong, Christine B. Peterson, Daniel J. McGrail, Anh Hoang, Xuesong Zhang, Truong Lam, Patrick G. Pilie, Haifeng Zhu, Kathryn E. Beckermann, Scott M. Haake, Sevinj Isgandrova, Margarita Martinez-Moczygemba, Nidhi Sahni, Nizar M. Tannir, Shiaw-Yih Lin, W. Kimryn Rathmell, Eric Jonasch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
PBRM1, encoding for a subunit of the SWI/SNF complex, is the second most frequently mutated gene in clear cell renal cell carcinoma (ccRCC). Here, the authors show that PBRM1 loss reduces IFNγ-mediated signalling resulting in a less immunogenic tumo
Externí odkaz:
https://doaj.org/article/2c2ffa7605cd4f008c5d3c780840e07f
Autor:
Christine B. Peterson, Truong Nguyen Anh Lam, Sevinj Isgandrova, Nizar M. Tannir, Eric Jonasch, Xian De Liu, Anh Hoang, Wen Kong, Nidhi Sahni, Daniel J. McGrail, Haifeng Zhu, Margarita Martinez-Moczygemba, Kathryn E. Beckermann, W. Kimryn Rathmell, Shiaw Yih Lin, Patrick G. Pilie, Xuesong Zhang, Scott M. Haake
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
A non-immunogenic tumor microenvironment (TME) is a significant barrier to immune checkpoint blockade (ICB) response. The impact of Polybromo-1 (PBRM1) on TME and response to ICB in renal cell carcinoma (RCC) remains to be resolved. Here we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169693e3a7a8721c7b30551fde62637b
https://doi.org/10.1038/s41467-020-15959-6
https://doi.org/10.1038/s41467-020-15959-6
Autor:
Xuesong Zhang, Patrick G. Pilie, Sevinj Isgandrova, Wen Kong, Lijun Zhou, Eric Jonasch, Anh Hoang, Margie M. Moczygemba, Xian De Liu
Publikováno v:
Cancer Immunology Research. 8:B48-B48
PBRM1 is a subunit of a SWI/SNF chromatin remodeling complex, and more than 30% of clear cell RCCs show PBRM1 mutations. The function of PBRM1 in tumor immune microenvironment, tumor prognosis and response to immune checkpoint therapies still remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b1a71b8ac3164322c78bce98017ba32
https://doi.org/10.1158/2326-6074.tumimm18-b48
https://doi.org/10.1158/2326-6074.tumimm18-b48
Autor:
Xian De Liu, Lijun Zhou, Anh Hoang, Truong Nguyen Anh Lam, Christine B. Peterson, Margie M. Moczygemba, Eric Jonasch, Haifeng Zhu, Xuesong Zhang, Wen Kong, Sevinj Isgandrova, Patrick G. Pilie
Publikováno v:
Cancer Research. 79:945-945
PBRM1 is a subunit of SWI/SNF complex that regulates chromatin accessibility for transcription factors, and more than 30% of clear cell renal cell carcinoma (RCC) contain PBRM1 mutations. Nivolumab (anti-PD-1) showed profound and prolonged response o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba932b302f0bb0e86a9e6463db05f739
https://doi.org/10.1158/1538-7445.am2019-945
https://doi.org/10.1158/1538-7445.am2019-945