Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes

Autor: Anne Eugster, Anna Lorenc, Martin Kotrulev, Yogesh Kamra, Manisha Goel, Katja Steinberg-Bains, Shereen Sabbah, Sevina Dietz, Ezio Bonifacio, Mark Peakman, Iria Gomez-Tourino

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Autoimmune diseases result from autoantigen-mediated activation of adaptive immunity; intriguingly, autoantigen-specific T cells are also present in healthy donors. An assessment of dynamic changes of this autoreactive repertoire in both hea

Externí odkaz: https://doaj.org/article/232b3f7f7b544729b1e9d70d032e0c11

Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice

Autor: Tatyana Grinenko, Anne Eugster, Lars Thielecke, Beáta Ramasz, Anja Krüger, Sevina Dietz, Ingmar Glauche, Alexander Gerbaulet, Malte von Bonin, Onur Basak, Hans Clevers, Triantafyllos Chavakis, Ben Wielockx

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Dependence of hematopoietic stem cell (HSC) fate on the phase of the cell cycle has not been demonstrated in vivo. Here, the authors find that HSCs can differentiate into a downstream progenitor without physical division, even before progressing into

Externí odkaz: https://doaj.org/article/681a9eaa5b95419b80609eae18b557be

Maternal Type 1 Diabetes Reduces Autoantigen-Responsive CD4+ T Cells in Offspring

Autor: Annett Lindner, Ramona Lickert, Nadine Hummel, Anne Eugster, Katharina Warncke, Ezio Bonifacio, Sevina Dietz, Anette-Gabriele Ziegler, Jan Knoop, Eva-Maria Sedlmeier, Anita Gavrisan

Publikováno v: Diabetes 69, 661-669 (2020)

Autoimmunity against pancreatic β-cell autoantigens is a characteristic of childhood type 1 diabetes (T1D). Autoimmunity usually appears in genetically susceptible children with the development of autoantibodies against (pro)insulin in early childho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c98480689f5186ce584d52c2a27b32
https://doi.org/10.2337/db19-0751

Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

Autor: George Hajishengallis, Triantafyllos Chavakis, Sevina Dietz, Peter Mirtschink, Peter J. Murray, Athanasios Ziogas, Marina Nati, Kyoung-Jin Chung, Ioannis Kourtzelis, Ben Wielockx, Eman Hagag, Panayotis Verginis, Ales Neuwirth, Mihai G. Netea, Jonas Schulte-Schrepping, Ian Henry, Pallavi Subramanian, Joachim L. Schultze, Tatyana Grinenko, Canan Has, Antonios Chatzigeorgiou, Sundary Sormendi, Anupam Sinha, Ioannis Mitroulis, Xiaofei Li, Lydia Kalafati, Aikaterini Hatzioannou, Andreas Dahl, António Miguel de Jesus Domingues, Mathias Lesche

Publikováno v: Cell, 183, 3, pp. 771-785.e12
Cell, 183, 771-785.e12
Cell 183(3), 771-785.e12 (2020). doi:10.1016/j.cell.2020.09.058
Cell
Kalafati, L, Kourtzelis, I, Schulte-Schrepping, J, Li, X, Hatzioannou, A, Grinenko, T, Hagag, E, Sinha, A, Has, C, Dietz, S, de Jesus Domingues, A M, Nati, M, Sormendi, S, Neuwirth, A, Chatzigeorgiou, A, Ziogas, A, Lesche, M, Dahl, A, Henry, I, Subramanian, P, Wielockx, B, Murray, P, Mirtschink, P, Chung, K-J, Schultze, J L, Netea, M G, Hajishengallis, G, Verginis, P, Mitroulis, I & Chavakis, T 2020, ' Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity ', Cell, vol. 183, no. 3, pp. 771-785 . https://doi.org/10.1016/j.cell.2020.09.058

Summary Trained innate immunity, induced via modulation of mature myeloid cells or their bone marrow progenitors, mediates sustained increased responsiveness to secondary challenges. Here, we investigated whether anti-tumor immunity can be enhanced t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c637a504dcda3e4fee30ef1cda9f210
https://hdl.handle.net/2066/228705

Maternal Type 1 Diabetes Reduces Autoantigen-Responsive CD4

Autor: Jan, Knoop, Anne, Eugster, Anita, Gavrisan, Ramona, Lickert, Eva-Maria, Sedlmeier, Sevina, Dietz, Annett, Lindner, Katharina, Warncke, Nadine, Hummel, Anette-Gabriele, Ziegler, Ezio, Bonifacio

Publikováno v: Diabetes. 69(4)

Autoimmunity against pancreatic β-cell autoantigens is a characteristic of childhood type 1 diabetes (T1D). Autoimmunity usually appears in genetically susceptible children with the development of autoantibodies against (pro)insulin in early childho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::44d8f464fc5d5d89e19c2622a6c8725b
https://pubmed.ncbi.nlm.nih.gov/31896551