RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells

Autor: Fuhui Chen, Sevim B. Gurler, David Novo, Cigdem Selli, Denis G. Alferez, Secil Eroglu, Kyriaki Pavlou, Jingwei Zhang, Andrew H. Sims, Neil E. Humphreys, Antony Adamson, Andrew Campbell, Owen J. Sansom, Cathy Tournier, Robert B. Clarke, Keith Brennan, Charles H. Streuli, Ahmet Ucar

Publikováno v: Chen, F, Gurler, S B, Novo, D, Selli, C, Alferez, D G, Eroglu, S, Pavlou, K, Zhang, J, Sims, A H, Humphreys, N E, Adamson, A, Campbell, A, Sansom, O J, Tournier, C, Clarke, R B, Brennan, K, Streuli, C H & Ucar, A 2023, ' RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells ', Oncogene, vol. 42, pp. 679-692 . https://doi.org/10.1038/s41388-022-02574-6

Breast cancer stem cells (BCSC) are presumed to be responsible for treatment resistance, tumor recurrence and metastasis of breast tumors. However, development of BCSC-targeting therapies has been held back by their heterogeneity and the lack of BCSC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1327f89053608b065c8bcfc5ed3d5f
https://doi.org/10.1038/s41388-022-02574-6