CYpHER: Catalytic extracellular targeted protein degradation with high potency and durable effect.

Autor: Crook ZR; Cyclera Therapeutics Inc, Seattle, WA 98115, USA. Present address of Z.R.C., G.P.S., and N.W.N.; Blaze Bioscience Inc., Seattle, WA 98109, USA.; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Sevilla GP; Cyclera Therapeutics Inc, Seattle, WA 98115, USA. Present address of Z.R.C., G.P.S., and N.W.N.; Blaze Bioscience Inc., Seattle, WA 98109, USA.; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Young P; Blaze Bioscience Inc., Seattle, WA 98109, USA., Girard EJ; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA 98105, USA. Present address of E.J.G. and J.M.O., Phi TD; Blaze Bioscience Inc., Seattle, WA 98109, USA., Howard M; NW Biosensor, Seattle, WA 98102., Price J; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA 98105, USA. Present address of E.J.G. and J.M.O., Olson JM; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA 98105, USA. Present address of E.J.G. and J.M.O., Nairn NW; Cyclera Therapeutics Inc, Seattle, WA 98115, USA. Present address of Z.R.C., G.P.S., and N.W.N.; Blaze Bioscience Inc., Seattle, WA 98109, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 23. Date of Electronic Publication: 2024 Apr 23.

A TfR-Binding Cystine-Dense Peptide Promotes Blood-Brain Barrier Penetration of Bioactive Molecules.

Autor: Crook ZR; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA., Girard E; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA., Sevilla GP; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA., Merrill M; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA., Friend D; Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA., Rupert PB; Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA., Pakiam F; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA., Nguyen E; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA., Yin C; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA., Ruff RO; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA., Hopping G; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA., Strand AD; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA., Finton KAK; Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA., Coxon M; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA., Mhyre AJ; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA., Strong RK; Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA., Olson JM; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA. Electronic address: jolson@fredhutch.org.

Publikováno v: Journal of molecular biology [J Mol Biol] 2020 Jun 26; Vol. 432 (14), pp. 3989-4009. Date of Electronic Publication: 2020 Apr 15.

Genetic diversity of the HLA system in human populations from the Sierra (Andean), Oriente (Amazonian) and Costa (Coastal) regions of Ecuador.

Autor: Galarza JM; Unidad de Genética y Molecular, Hospital Carlos Andrade Marín, Instituto Ecuatoriano de Seguridad Social, Quito, Ecuador. Electronic address: jgalarzag@iess.gob.ec., Barquera R; Laboratorio de Genética Molecular, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico; Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany. Electronic address: barquera@shh.mpg.de., Álvarez AMT; Facultad de Ciencias de la Salud, Universidad de las Américas, Quito, Ecuador., Hernández Zaragoza DI; Laboratorio de Genética Molecular, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico., Sevilla GP; Unidad de Genética y Molecular, Hospital Carlos Andrade Marín, Instituto Ecuatoriano de Seguridad Social, Quito, Ecuador. Electronic address: aperalta@iess.gob.ec., Tamayo A; Unidad de Genética y Molecular, Hospital Carlos Andrade Marín, Instituto Ecuatoriano de Seguridad Social, Quito, Ecuador., Pérez M; Escuela de Ciencias Biológicas e Ingeniería, Universidad de Investigación de Tecnología Experimental Yachay, Urcuquí, Ecuador., Dávila D; Facultad de Ciencias de la Salud, Universidad de las Américas, Quito, Ecuador., Birnberg L; Unidad de Genética y Molecular, Hospital Carlos Andrade Marín, Instituto Ecuatoriano de Seguridad Social, Quito, Ecuador., Alonzo VA; Laboratorio de Genética Molecular, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico. Electronic address: victor_acuna@inah.gob.mx., Krause J; Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany. Electronic address: krause@shh.mpg.de., Grijalva M; Departamento de Ciencias de la Vida y Centro de Nanociencia y Nanotecnología, Universidad de las Fuerzas Armadas ESPE, Sangolquí, Ecuador. Electronic address: rmgrijalva@espe.edu.ec.

Publikováno v: Human immunology [Hum Immunol] 2018 Sep; Vol. 79 (9), pp. 639-650. Date of Electronic Publication: 2018 Jun 13.

Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets.

Autor: Crook ZR; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N Room D4-100, Seattle, WA, 98109, USA., Sevilla GP; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N Room D4-100, Seattle, WA, 98109, USA., Friend D; Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N Room B3-183, Seattle, WA, 98109, USA., Brusniak MY; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N Room D4-100, Seattle, WA, 98109, USA., Bandaranayake AD; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N Room D4-100, Seattle, WA, 98109, USA., Clarke M; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N Room D4-100, Seattle, WA, 98109, USA., Gewe M; Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N Room B3-183, Seattle, WA, 98109, USA., Mhyre AJ; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N Room D4-100, Seattle, WA, 98109, USA., Baker D; Department of Biochemistry, University of Washington, Molecular Engineering and Sciences, Box 351655, Seattle, WA, 98195, USA., Strong RK; Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N Room B3-183, Seattle, WA, 98109, USA., Bradley P; Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N Room M1-B514, Seattle, WA, 98109, USA. pbradley@fredhutch.org., Olson JM; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N Room D4-100, Seattle, WA, 98109, USA. jimmyo@uw.edu.

Publikováno v: Nature communications [Nat Commun] 2017 Dec 21; Vol. 8 (1), pp. 2244. Date of Electronic Publication: 2017 Dec 21.