Azetidine-based selective glycine transporter-1 (GlyT1) inhibitors with memory enhancing properties

Autor: Hudson, Andrew R., Santora, Vincent J., Petroski, Robert E., Almos, Theresa A., Anderson, Gary, Barido, Richard, Basinger, Jillian, Bellows, Chris L., Bookser, Brett C., Broadbent, Nicola J., Cabebe, Clifford, Chai, Chih-Kun, Chen, Mi, Chow, Stephine, Chung, De Michael, Heger, Lindsay, Danks, Anne M., Freestone, Graeme C., Gitnick, Dany, Gupta, Varsha, Hoffmaster, Christine, Kaplan, Alan P., Kennedy, Michael R., Lee, Dong, Limberis, James, Ly, Kiev, Mak, Chi Ching, Masatsugu, Brittany, Morse, Andrew C., Na, Jim, Neul, David, Nikpur, John, Renick, Joel, Sebring, Kristen, Sevidal, Samantha, Tabatabaei, Ali, Wen, Jenny, Xia, Shouzhen, Yan, Yingzhuo, Yoder, Zachary W., Zook, Douglas, Peters, Marco, Breitenbucher, J. Guy

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 15 July 2020 30(14)

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Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1) Inhibitors with Memory Enhancing Properties.

Autor: Santora VJ; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Almos TA; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Barido R; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Basinger J; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Bellows CL; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Bookser BC; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Breitenbucher JG; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Broadbent NJ; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Cabebe C; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Chai CK; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Chen M; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Chow S; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Chung M; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Crickard L; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Danks AM; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Freestone GC; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Gitnick D; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Gupta V; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Hoffmaster C; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Hudson AR; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Kaplan AP; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Kennedy MR; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Lee D; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Limberis J; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Ly K; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Mak CC; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Masatsugu B; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Morse AC; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Na J; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Neul D; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Nikpur J; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Peters M; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Petroski RE; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Renick J; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Sebring K; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Sevidal S; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Tabatabaei A; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Wen J; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Yan Y; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Yoder ZW; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States., Zook D; Dart NeuroScience LLC , 12278 Scripps Summit Drive , San Diego , California 92121 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Jul 26; Vol. 61 (14), pp. 6018-6033. Date of Electronic Publication: 2018 Jul 11.