In Silico and In Vivo Studies of a Tumor-Penetrating and Interfering Peptide with Antitumoral Effect on Xenograft Models of Breast Cancer

Autor: Gustavo H. Marin, Samuel Murail, Laura Andrini, Marcela Garcia, Severine Loisel, Pierre Tuffery, Angelita Rebollo

Publikováno v: Pharmaceutics, Vol 15, Iss 4, p 1180 (2023)

The combination of a tumor-penetrating peptide (TPP) with a peptide able to interfere with a given protein–protein interaction (IP) is a promising strategy with potential clinical application. Little is known about the impact of fusing a TPP with a

Externí odkaz: https://doaj.org/article/57d6c31cabd7494ca27beb38b98645d3

Bifunctional Therapeutic Peptides for Targeting Malignant B Cells and Hepatocytes: Proof of Concept in Chronic Lymphocytic Leukemia

Autor: Lorena Simón-Gracia, Eric Savier, Lynda Aoudjehane, Filomena Conti, Tambet Teesalu, Frédéric Charlotte, Jean Yves Brossas, Severine Loisel, Olivier Scatton, Christophe Parizot, Angelita Rebollo

Publikováno v: Advanced Therapeutics
Advanced Therapeutics, Wiley, 2020, 3 (12), ⟨10.1002/adtp.202000131⟩
Advanced Therapeutics, 2020, 3 (12), ⟨10.1002/adtp.202000131⟩

International audience; Protein-protein interactions are well recognized as therapeutic targets and therefore interfering peptides (IP) that block these interactions are receiving increasing attention. Four different tumor-penetrating peptides (TPPs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3415a4c0254c7d0f402ee31e551bac4c
https://hal-cnrs.archives-ouvertes.fr/hal-03292694

Local Long-Term Expression of Lentivirally Delivered IL-10 in the Lung Attenuates Obliteration of Intrapulmonary Allograft Airways

Autor: Shaf Keshavjee, S. Hirayama, Jonathan C. Yeung, G. Zehong, Severine Loisel-Meyer, Marcelo Cypel, Jeffrey A. Medin, Masaaki Sato, D. Wagnetz, Mingyao Liu

Publikováno v: Human Gene Therapy. 22:1453-1460

Obliterative bronchiolitis (OB) is a form of chronic rejection after lung transplantation. Lentiviral vectors (LVs) facilitate long-term gene transduction in many tissues and organs. We hypothesized that lentiviral gene transfer of interleukin (IL)-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28204b4f10b0d397282e50a2d101ac54
https://doi.org/10.1089/hum.2010.225

Potent induction of B- and T-cell immunity against human carcinoembryonic antigen-expressing tumors in human carcinoembryonic antigen transgenic mice mediated by direct lentivector injection

Autor: Robert Kammerer, Nobuo Mizue, Jacopo Mariotti, Wolfgang Zimmermann, Severine Loisel-Meyer, Jason Foley, Miriam E. Mossoba, Boro Dropulic, Daniel H. Fowler, J. Andrea McCart, Tania C. Felizardo, Robert Keefe, Jeffrey A. Medin

Publikováno v: Molecular Cancer Therapeutics. 8:692-702

The applicability of immunotherapy would be dramatically broadened to a greater number of recipients if direct “off-the-shelf” products could be engineered to engender functionally potent immune responses against true “self”-tumor antigens. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92cfafbfa80d3b900a8f18915472c079
https://doi.org/10.1158/1535-7163.mct-08-0769

Glut1-mediated glucose transport regulates HIV infection

Autor: Kondala R. Atkuri, Severine Loisel-Meyer, Marco Craveiro, Sandrina Kinet, Marc Sitbon, Louise Swainson, Marion Martinez, Jean-Luc Battini, Cédric Mongellaz, Caroline Costa, Els Verhoeyen, Leal Oburoglu, Naomi Taylor, Leonore A. Herzenberg, François-Loïc Cosset, Leonard A. Herzenberg

Publikováno v: Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences; Vol 109

Cell cycle entry is commonly considered to positively regulate HIV-1 infection of CD4 T cells, raising the question as to how quiescent lymphocytes, representing a large portion of the viral reservoir, are infected in vivo. Factors such as the homeos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6040b4f342b9cbcaaa831e0cd08b6b
https://pubmed.ncbi.nlm.nih.gov/22308487