Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy

Autor: Brigida Boccanegra, Ornella Cappellari, Paola Mantuano, Daniela Trisciuzzi, Antonietta Mele, Lisamaura Tulimiero, Michela De Bellis, Santa Cirmi, Francesca Sanarica, Alessandro Giovanni Cerchiara, Elena Conte, Ramona Meanti, Laura Rizzi, Elena Bresciani, Severine Denoyelle, Jean-Alain Fehrentz, Gabriele Cruciani, Orazio Nicolotti, Antonella Liantonio, Antonio Torsello, Annamaria De Luca

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionGrowth hormone secretagogues (GHSs) exert multiple actions, being able to activate GHS-receptor 1a, control inflammation and metabolism, to enhance GH/insulin-like growth factor-1 (IGF-1)-mediated myogenesis, and to inhibit angiotensin-co

Externí odkaz: https://doaj.org/article/d37929ca58e6446b9eba622262e2222e

LEAP2 Impairs the Capability of the Growth Hormone Secretagogue Receptor to Regulate the Dopamine 2 Receptor Signaling

Autor: Emilio R. Mustafá, Santiago Cordisco González, Marjorie Damian, Sonia Cantel, Severine Denoyelle, Renaud Wagner, Helgi B. Schiöth, Jean-Alain Fehrentz, Jean-Louis Banères, Mario Perelló, Jesica Raingo

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

The growth hormone secretagogue receptor (GHSR) signals in response to ghrelin, but also acts via ligand-independent mechanisms that include either constitutive activation or interaction with other G protein-coupled receptors, such as the dopamine 2

Externí odkaz: https://doaj.org/article/0e77ad9215a246d98475647b715d366f

Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor

Autor: Laurent J. Catoire, Sonia Cantel, Marjorie Damian, Jean-Alain Fehrentz, Maxime Louet, Antoniel As Gomes, Jean-Louis Banères, Sophie Mary, Paulo R. Batista, David Perahia, Paulo Mascarello Bisch, Mauricio Gs Costa, Khoubaib Ben Haj Salah, Céline M'Kadmi, Marina Casiraghi, Pedro Renault, Severine Denoyelle, Nicolas Floquet

Publikováno v: eLife
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/eLife.63201⟩
eLife, Vol 10 (2021)
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/elife.63201⟩

International audience; There is increasing support for water molecules playing a role in signal propagation through G protein-coupled receptors (GPCRs). However, exploration of the hydration features of GPCRs is still in its infancy. Here, we combin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7699a75687941d10e1c426d2dcfb4bfe
http://europepmc.org/articles/PMC8416020

Development of non-peptidic inverse agonists of the ghrelin receptor (GHSR) based on the 1,2,4-triazole scaffold

Autor: Sonia Cantel, Jean-Alain Fehrentz, Severine Denoyelle, Catherine Oiry, Gimena Fernandez, Mario Perello, Sylvie Peraldi-Roux, Jean-Louis Banères, Céline M'Kadmi, Guadalupe García Romero, Jacky Marie, Sophie Mary, Mathieu Maingot, Marjorie Damian, Anne-Laure Blayo, Jérémie Neasta, Khoubaib Ben Haj Salah

Publikováno v: Journal of Clinical Chemistry and Clinical Biochemistry
Journal of Clinical Chemistry and Clinical Biochemistry, 2020, ⟨10.1021/acs.jmedchem.9b02122⟩
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2020, 63 (19), pp.10796-10815. ⟨10.1021/acs.jmedchem.9b02122⟩

International audience; GHSR controls, among others, growth hormone and insulin secretion, adiposity, feeding and glucose metabolism. Therefore, an inverse agonist ligand capable of selectively targeting GHSR and reducing its high constitutive activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff4a1b5d5080c225244a11ba684780e
https://hal.archives-ouvertes.fr/hal-03023656

Allosteric modulation of ghrelin receptor signaling by lipids

Autor: Marjorie Damian, Maxime Louet, Antoniel Augusto Severo Gomes, Céline M’Kadmi, Séverine Denoyelle, Sonia Cantel, Sophie Mary, Paulo M. Bisch, Jean-Alain Fehrentz, Laurent J. Catoire, Nicolas Floquet, Jean-Louis Banères

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

The membrane is an integral component of the G protein-coupled receptor signaling machinery. Here authors demonstrate that lipids regulate the signaling efficacy and selectivity of the ghrelin receptor GHSR through specific interactions and bulk effe

Externí odkaz: https://doaj.org/article/2ff1774b14b842c1ba2707a2e704a84a