Zobrazeno 1 - 10 of 33 pro vyhledávání: '"Severine, Van Slambrouck"'
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5,6,7,3′,4′,5′-Hexamethoxyflavone inhibits growth of triple-negative breast cancer cells via suppression of MAPK and Akt signaling pathways and arresting cell cycle
Autor: Natasha Borah, Susan McDonnell, Shimara Gunawardana, Haydee M. Torres, Severine Van Slambrouck
Publikováno v: International Journal of Oncology
Natural components continue to be an important source for the discovery and development of novel anticancer agents. Polymethoxyflavones are a class of flavonoids found in citrus fruits and medicinal plants used in traditional medicine. In the present
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0fc577a2803f0a3e2ce56a40f65b91b
http://europepmc.org/articles/PMC5673012
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3
The Flavonoid Metabolite 2,4,6-Trihydroxybenzoic Acid Is a CDK Inhibitor and an Anti-Proliferative Agent: A Potential Role in Cancer Prevention
Autor: Ranjini Sankaranarayanan, Chaitanya K. Valiveti, D. Ramesh Kumar, Siddharth S. Kesharwani, Joy Scaria, Hemachand Tummala, Teresa Seefeldt, G. Jayarama Bhat, Severine Van Slambrouck
Publikováno v: Cancers, Vol 11, Iss 3, p 427 (2019)
Cancers
Volume 11
Issue 3
Flavonoids have emerged as promising compounds capable of preventing colorectal cancer (CRC) due to their anti-oxidant and anti-inflammatory properties. It is hypothesized that the metabolites of flavonoids are primarily responsible for the observed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b61ed3741392a2dc1162387f47c9de
https://www.mdpi.com/2072-6694/11/3/427
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4
Abstract 101: Studies on the flavonoid metabolite 2,4,6-trihydroxybenzoic acid as a CDK inhibitor and anti-proliferative agent: Potential role in cancer prevention
Autor: Chaitanya K. Valiveti, Jayarama B. Gunaje, Teresa Seefeldt, Hemachand Tummala, Severine Van Slambrouck, Siddharth S. Kesharwani, Ranjini Sankaranarayanan, D. Ramesh Kumar
Publikováno v: Cancer Research. 80:101-101
Colorectal cancer (CRC) is the second highest cause of cancer deaths in the United States according to Center for Disease Control. Increasing evidences suggest that a diet rich in fruits and vegetables will reduce incidences of colorectal adenomas. W
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e276200bdf67849fefbfbf55a7ff08f
https://doi.org/10.1158/1538-7445.am2020-101
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5
Clustering of monosialyl-Gb5 initiates downstream signalling events leading to invasion of MCF-7 breast cancer cells
Autor: Wim F.A. Steelant, Severine Van slambrouck
Publikováno v: Biochemical Journal. 401:689-699
Invasion is a complex process controlled by secretion and activation of proteases, alteration of integrin levels and GSL (glycosphingolipid) patterns. Differential organization of GSLs with specific membrane proteins and signal transducers in GEMs (G
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0490175ac7b2a8021f01b7c6ba8622ea
https://doi.org/10.1042/bj20060944
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6
Ethacrynic acid analogues lacking the α,β-unsaturated carbonyl unit—Potential anti-metastatic drugs
Autor: Elizabeth K. Vogel, Enoch A. Adogla, Zack E. Bryant, Catherine N. Kaminski, Romy F.J. Janser, Ingo Janser, Ranjith K. Meka, Seth L. Ferrey, Jaimie L. Wharton, Cynthia M. Tilley, Severine Van slambrouck, Wim F.A. Steelant
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:1848-1850
A series of ethacrynic acid analogues, lacking the alpha,beta-unsaturated carbonyl unit, was synthesized and subsequently evaluated for their ability to inhibit the migration of human breast cancer cells, MCF-7/AZ. Several of the analogues were alrea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea7e40ee10796b69293def3dc74e3e2
https://doi.org/10.1016/j.bmcl.2010.01.144
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7
Structural simplification of bioactive natural products with multicomponent synthesis. 4. 4H-pyrano-[2,3-b]naphthoquinones with anticancer activity
Autor: Aaron R. Jenkins, Mikhail Yu. Antipin, Nikolai M. Evdokimov, Wim F.A. Steelant, Igor V. Magedov, Severine Van slambrouck, Paul Tongwa, Jeff Altig, Alexander Kornienko, Artem S. Kireev, Dustin T. Lima
Publikováno v: Bioorganicmedicinal chemistry letters. 22(16)
4H-Pyrano-[2,3-b]naphthoquinone is a structural motif commonly found in natural products manifesting anticancer activities. As part of a program aimed at structural simplification of bioactive natural products utilizing multicomponent synthetic proce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb340f678eea13eb86568f5db0ef489d
https://pubmed.ncbi.nlm.nih.gov/22819765
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10
Inhibitory Effects of Ethacrynic Acid Analogues Lacking the α,β-Unsaturated Carbonyl Unit and para-Acylated Phenols on Human Cancer Cells
Autor: Zack E. Bryant, Melissa S. Candelaria-Lyons, Severine Van slambrouck, Romy F.J. Janser, Brittni Briann Romero, Medina Jabarkhail, Wim F.A. Steelant, Ingo Janser
A series of ethacrynic acid analogues, lacking the α,β-unsaturated carbonyl unit, was synthesized and subsequently evaluated for their ability to inhibit the migration of human breast cancer cells, Hs578Ts(i)8 as well as of human prostate cancer ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0368807cffba298fb309c29facfba23f
https://europepmc.org/articles/PMC3057390/
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